Skip to main content
PMC home page
Environmental Health Perspectives logoLink to Environmental Health Perspectives
. 1995 Feb;103(Suppl 1):111–113. doi: 10.1289/ehp.95103s1111

Genotoxic monitoring of workers at a hazardous waste disposal site in Mexico.

M E Gonsebatt 1, A M Salazar 1, R Montero 1, F Díaz Barriga 1, L Yáñez 1, H Gómez 1, P Ostrosky-Wegman 1
PMCID: PMC1519331  PMID: 7621789

Abstract

Chromosomal aberration and sister chromatid exchange (SCE) frequencies were determined in lymphocytes cultured from 12 high-risk individuals working at a landfill for hazardous waste disposal. Cell proliferation kinetics (CPK) was also determined. Compared with 7 control individuals, no effects were observed with respect to SCE nor on CPK. However, the workers exhibited significantly higher frequencies of chromatid and chromosomal deletions, the magnitude of which was related with exposure time. This study suggests that when high-risk exposure is suspected, determining biomarkers of genotoxic damage (e.g., chromosomal aberrations), is useful for risk assessments.

Full text

PDF
112

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Ashby J. Comparison of techniques for monitoring human exposure to genotoxic chemicals. Mutat Res. 1988 Mar;204(3):543–551. doi: 10.1016/0165-1218(88)90048-1. [DOI] [PubMed] [Google Scholar]
  2. Bender M. A., Leonard R. C., White O., Jr, Costantino J. P., Redmond C. K. Chromosomal aberrations and sister-chromatid exchanges in lymphocytes from coke oven workers. Mutat Res. 1988 Sep;206(1):11–16. doi: 10.1016/0165-1218(88)90135-8. [DOI] [PubMed] [Google Scholar]
  3. De Ferrari M., Artuso M., Bonassi S., Bonatti S., Cavalieri Z., Pescatore D., Marchini E., Pisano V., Abbondandolo A. Cytogenetic biomonitoring of an Italian population exposed to pesticides: chromosome aberration and sister-chromatid exchange analysis in peripheral blood lymphocytes. Mutat Res. 1991 May;260(1):105–113. doi: 10.1016/0165-1218(91)90086-2. [DOI] [PubMed] [Google Scholar]
  4. Díaz-Barriga F., Santos M. A., Yañez L., Cuellar J. A., Ostrosky-Wegman P., Montero R., Perez A., Ruiz E., Garcia A., Gomez H. Biological monitoring of workers at a recently opened hazardous waste disposal site. J Expo Anal Environ Epidemiol. 1993;3 (Suppl 1):63–71. [PubMed] [Google Scholar]
  5. Funes-Cravioto F., Lambert B., Lindsten J., Ehrenberg L., Natarajan A. T., Osterman-Golkar S. Letter: chromosome aberrations in workers exposed to vinyl chloride. Lancet. 1975 Feb 22;1(7904):459–459. doi: 10.1016/s0140-6736(75)91534-2. [DOI] [PubMed] [Google Scholar]
  6. Galloway S. M., Berry P. K., Nichols W. W., Wolman S. R., Soper K. A., Stolley P. D., Archer P. Chromosome aberrations in individuals occupationally exposed to ethylene oxide, and in a large control population. Mutat Res. 1986 Apr-May;170(1-2):55–74. doi: 10.1016/0165-1218(86)90082-0. [DOI] [PubMed] [Google Scholar]
  7. Kourakis A., Mouratidou M., Kokkinos G., Barbouti A., Kotsis A., Mourelatos D., Dozi-Vassiliades J. Frequencies of chromosomal aberrations in pesticide sprayers working in plastic green houses. Mutat Res. 1992 May 16;279(2):145–148. doi: 10.1016/0165-1218(92)90256-y. [DOI] [PubMed] [Google Scholar]
  8. Ostrosky-Wegman P., García G., Montero R., Pérez Romero B., Alvarez Chacón R., Cortinas de Nava C. Susceptibility to genotoxic effects of niclosamide in human peripheral lymphocytes exposed in vitro and in vivo. Mutat Res. 1986 Jan;173(1):81–87. doi: 10.1016/0165-7992(86)90015-1. [DOI] [PubMed] [Google Scholar]
  9. Ostrosky-Wegman P., Gonsebatt M. E., Montero R., Vega L., Barba H., Espinosa J., Palao A., Cortinas C., García-Vargas G., del Razo L. M. Lymphocyte proliferation kinetics and genotoxic findings in a pilot study on individuals chronically exposed to arsenic in Mexico. Mutat Res. 1991 Sep-Oct;250(1-2):477–482. doi: 10.1016/0027-5107(91)90204-2. [DOI] [PubMed] [Google Scholar]
  10. Páldy A., Puskás N., Vincze K., Hadházi M. Cytogenetic studies on rural populations exposed to pesticides. Mutat Res. 1987 Mar;187(3):127–132. doi: 10.1016/0165-1218(87)90079-6. [DOI] [PubMed] [Google Scholar]
  11. Sarto F., Cominato I., Pinton A. M., Brovedani P. G., Faccioli C. M., Bianchi V., Levis A. G. Cytogenetic damage in workers exposed to ethylene oxide. Mutat Res. 1984 Nov-Dec;138(2-3):185–195. doi: 10.1016/0165-1218(84)90043-0. [DOI] [PubMed] [Google Scholar]
  12. Schmid E., Bauchinger M., Hauf R. Chromosome changes with time in lymphocytes after occupational exposure to toluene. Mutat Res. 1985 Jan-Feb;142(1-2):37–39. doi: 10.1016/s0165-7992(85)80009-9. [DOI] [PubMed] [Google Scholar]
  13. Srám R. J., Holá N., Kotesovec F., Vávra R. Chromosomal abnormalities in soft coal open-cast mining workers. Mutat Res. 1985 Dec;144(4):271–275. doi: 10.1016/0165-7992(85)90063-6. [DOI] [PubMed] [Google Scholar]
  14. Wiencke J. K., Yager J. W. Specificity of arsenite in potentiating cytogenetic damage induced by the DNA crosslinking agent diepoxybutane. Environ Mol Mutagen. 1992;19(3):195–200. doi: 10.1002/em.2850190303. [DOI] [PubMed] [Google Scholar]
  15. Zhou X. T., Li L. R., Cui M. Y., Yu R. F., Li L., Yan Z. A. Cytogenetic monitoring of petrochemical workers. Mutat Res. 1986 Dec;175(4):237–242. doi: 10.1016/0165-7992(86)90060-6. [DOI] [PubMed] [Google Scholar]
  16. al-Sabti K., Lloyd D. C., Edwards A. A., Stegnar P. A survey of lymphocyte chromosomal damage in Slovenian workers exposed to occupational clastogens. Mutat Res. 1992;280(3):215–223. doi: 10.1016/0165-1218(92)90051-z. [DOI] [PubMed] [Google Scholar]

Articles from Environmental Health Perspectives are provided here courtesy of National Institute of Environmental Health Sciences

RESOURCES