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. 1993 Apr;100:45–56. doi: 10.1289/ehp.9310045

Human health effects of air pollution.

L J Folinsbee 1
PMCID: PMC1519570  PMID: 8354181

Abstract

Over the past three or four decades, there have been important advances in the understanding of the actions, exposure-response characteristics, and mechanisms of action of many common air pollutants. A multidisciplinary approach using epidemiology, animal toxicology, and controlled human exposure studies has contributed to the database. This review will emphasize studies of humans but will also draw on findings from the other disciplines. Air pollutants have been shown to cause responses ranging from reversible changes in respiratory symptoms and lung function, changes in airway reactivity and inflammation, structural remodeling of pulmonary airways, and impairment of pulmonary host defenses, to increased respiratory morbidity and mortality. Quantitative and qualitative understanding of the effects of a small group of air pollutants has advanced considerably, but the understanding is by no means complete, and the breadth of effects of all air pollutants is only partially understood.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AMDUR M. O., MELVIN W. W., Jr, DRINKER P. Effects of inhalation of sulphur dioxide by man. Lancet. 1953 Oct 10;265(6789):758–759. doi: 10.1016/s0140-6736(53)91455-x. [DOI] [PubMed] [Google Scholar]
  2. AMDUR M. O., SILVERMAN L., DRINKER P. Inhalation of sulfuric acid mist by human subjects. AMA Arch Ind Hyg Occup Med. 1952 Oct;6(4):305–313. [PubMed] [Google Scholar]
  3. Adams K. F., Koch G., Chatterjee B., Goldstein G. M., O'Neil J. J., Bromberg P. A., Sheps D. S. Acute elevation of blood carboxyhemoglobin to 6% impairs exercise performance and aggravates symptoms in patients with ischemic heart disease. J Am Coll Cardiol. 1988 Oct;12(4):900–909. doi: 10.1016/0735-1097(88)90452-4. [DOI] [PubMed] [Google Scholar]
  4. Adams W. C., Brookes K. A., Schelegle E. S. Effects of NO2 alone and in combination with O3 on young men and women. J Appl Physiol (1985) 1987 Apr;62(4):1698–1704. doi: 10.1152/jappl.1987.62.4.1698. [DOI] [PubMed] [Google Scholar]
  5. Allred E. N., Bleecker E. R., Chaitman B. R., Dahms T. E., Gottlieb S. O., Hackney J. D., Pagano M., Selvester R. H., Walden S. M., Warren J. Short-term effects of carbon monoxide exposure on the exercise performance of subjects with coronary artery disease. N Engl J Med. 1989 Nov 23;321(21):1426–1432. doi: 10.1056/NEJM198911233212102. [DOI] [PubMed] [Google Scholar]
  6. Andersen I. B., Lundqvist G. R., Jensen P. L., Proctor D. F. Human response to controlled levels of sulfur dioxide. Arch Environ Health. 1974 Jan;28(1):31–39. doi: 10.1080/00039896.1974.10666429. [DOI] [PubMed] [Google Scholar]
  7. Aronow W. S., Harris C. N., Isbell M. W., Rokaw S. N., Imparato B. Effect of freeway travel on angina pectoris. Ann Intern Med. 1972 Nov;77(5):669–676. doi: 10.7326/0003-4819-77-5-669. [DOI] [PubMed] [Google Scholar]
  8. Aronow W. S., Isbell M. W. Carbon monoxide effect on exercise-induced angina pectoris. Ann Intern Med. 1973 Sep;79(3):392–395. doi: 10.7326/0003-4819-79-3-392. [DOI] [PubMed] [Google Scholar]
  9. Avol E. L., Linn W. S., Shamoo D. A., Spier C. E., Valencia L. M., Venet T. G., Trim S. C., Hackney J. D. Short-term respiratory effects of photochemical oxidant exposure in exercising children. JAPCA. 1987 Feb;37(2):158–162. doi: 10.1080/08940630.1987.10466210. [DOI] [PubMed] [Google Scholar]
  10. Avol E. L., Linn W. S., Venet T. G., Shamoo D. A., Hackney J. D. Comparative respiratory effects of ozone and ambient oxidant pollution exposure during heavy exercise. J Air Pollut Control Assoc. 1984 Aug;34(8):804–809. doi: 10.1080/00022470.1984.10465814. [DOI] [PubMed] [Google Scholar]
  11. Ayres S. M., Mueller H. S., Gregory J. J., Giannelli S., Jr, Penny J. L. Systemic and myocardial hemodynamic responses to relatively small concentrations of carboxyhemoglobin (COHB). Arch Environ Health. 1969 Apr;18(4):699–709. doi: 10.1080/00039896.1969.10665473. [DOI] [PubMed] [Google Scholar]
  12. Barr B. C., Hyde D. M., Plopper C. G., Dungworth D. L. Distal airway remodeling in rats chronically exposed to ozone. Am Rev Respir Dis. 1988 Apr;137(4):924–938. doi: 10.1164/ajrccm/137.4.924. [DOI] [PubMed] [Google Scholar]
  13. Barry B. E., Miller F. J., Crapo J. D. Effects of inhalation of 0.12 and 0.25 parts per million ozone on the proximal alveolar region of juvenile and adult rats. Lab Invest. 1985 Dec;53(6):692–704. [PubMed] [Google Scholar]
  14. Bates D. V. Air pollutants and the human lung. The James Waring memorial lecture. Am Rev Respir Dis. 1972 Jan;105(1):1–13. doi: 10.1164/arrd.1972.105.1.1. [DOI] [PubMed] [Google Scholar]
  15. Bates D. V., Bell G. M., Burnham C. D., Hazucha M., Mantha J., Pengelly L. D., Silverman F. Short-term effects of ozone on the lung. J Appl Physiol. 1972 Feb;32(2):176–181. doi: 10.1152/jappl.1972.32.2.176. [DOI] [PubMed] [Google Scholar]
  16. Bauer M. A., Utell M. J., Morrow P. E., Speers D. M., Gibb F. R. Inhalation of 0.30 ppm nitrogen dioxide potentiates exercise-induced bronchospasm in asthmatics. Am Rev Respir Dis. 1986 Dec;134(6):1203–1208. doi: 10.1164/arrd.1986.134.6.1203. [DOI] [PubMed] [Google Scholar]
  17. Beard R. R., Wertheim G. A. Behavioral impairment associated with small doses of carbon monoxide. Am J Public Health Nations Health. 1967 Nov;57(11):2012–2022. doi: 10.2105/ajph.57.11.2012. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Beckett W. S., McDonnell W. F., Horstman D. H., House D. E. Role of the parasympathetic nervous system in acute lung response to ozone. J Appl Physiol (1985) 1985 Dec;59(6):1879–1885. doi: 10.1152/jappl.1985.59.6.1879. [DOI] [PubMed] [Google Scholar]
  19. Bedi J. F., Drechsler-Parks D. M., Horvath S. M. Duration of increased pulmonary function sensitivity to an initial ozone exposure. Am Ind Hyg Assoc J. 1985 Dec;46(12):731–734. doi: 10.1080/15298668591395643. [DOI] [PubMed] [Google Scholar]
  20. Bedi J. F., Folinsbee L. J., Horvath S. M., Ebenstein R. S. Human exposure to sulfur dioxide and ozone: absence of a synergistic effect. Arch Environ Health. 1979 Jul-Aug;34(4):233–239. doi: 10.1080/00039896.1979.10667405. [DOI] [PubMed] [Google Scholar]
  21. Bedi J. F., Horvath S. M., Folinsbee L. J. Human exposure to sulfur dioxide and ozone in a high temperature-humidity environment. Am Ind Hyg Assoc J. 1982 Jan;43(1):26–30. doi: 10.1080/15298668291409316. [DOI] [PubMed] [Google Scholar]
  22. Bellinger D., Leviton A., Waternaux C., Needleman H., Rabinowitz M. Longitudinal analyses of prenatal and postnatal lead exposure and early cognitive development. N Engl J Med. 1987 Apr 23;316(17):1037–1043. doi: 10.1056/NEJM198704233161701. [DOI] [PubMed] [Google Scholar]
  23. Benignus V. A., Muller K. E., Malott C. M. Dose-effects functions for carboxyhemoglobin and behavior. Neurotoxicol Teratol. 1990 Mar-Apr;12(2):111–118. doi: 10.1016/0892-0362(90)90121-r. [DOI] [PubMed] [Google Scholar]
  24. Benignus V. A., Muller K. E., Smith M. V., Pieper K. S., Prah J. D. Compensatory tracking in humans with elevated carboxyhemoglobin. Neurotoxicol Teratol. 1990 Mar-Apr;12(2):105–110. doi: 10.1016/0892-0362(90)90120-2. [DOI] [PubMed] [Google Scholar]
  25. Bethel R. A., Epstein J., Sheppard D., Nadel J. A., Boushey H. A. Sulfur dioxide-induced bronchoconstriction in freely breathing, exercising, asthmatic subjects. Am Rev Respir Dis. 1983 Dec;128(6):987–990. doi: 10.1164/arrd.1983.128.6.987. [DOI] [PubMed] [Google Scholar]
  26. Bethel R. A., Erle D. J., Epstein J., Sheppard D., Nadel J. A., Boushey H. A. Effect of exercise rate and route of inhalation on sulfur-dioxide-induced bronchoconstriction in asthmatic subjects. Am Rev Respir Dis. 1983 Oct;128(4):592–596. doi: 10.1164/arrd.1983.128.4.592. [DOI] [PubMed] [Google Scholar]
  27. Bethel R. A., Sheppard D., Epstein J., Tam E., Nadel J. A., Boushey H. A. Interaction of sulfur dioxide and dry cold air in causing bronchoconstriction in asthmatic subjects. J Appl Physiol Respir Environ Exerc Physiol. 1984 Aug;57(2):419–423. doi: 10.1152/jappl.1984.57.2.419. [DOI] [PubMed] [Google Scholar]
  28. Bornschein R. L., Hammond P. B., Dietrich K. N., Succop P., Krafft K., Clark S., Berger O., Pearson D., Que Hee S. The Cincinnati prospective study of low-level lead exposure and its effects on child development: protocol and status report. Environ Res. 1985 Oct;38(1):4–18. doi: 10.1016/0013-9351(85)90067-2. [DOI] [PubMed] [Google Scholar]
  29. Bushnell P. J., Bowman R. E., Allen J. R., Marlar R. J. Scotopic vision deficits in young monkeys exposed to lead. Science. 1977 Apr 15;196(4287):333–335. doi: 10.1126/science.403610. [DOI] [PubMed] [Google Scholar]
  30. Bylin G., Hedenstierna G., Lindvall T., Sundin B. Ambient nitrogen dioxide concentrations increase bronchial responsiveness in subjects with mild asthma. Eur Respir J. 1988 Jul;1(7):606–612. [PubMed] [Google Scholar]
  31. Bylin G., Lindvall T., Rehn T., Sundin B. Effects of short-term exposure to ambient nitrogen dioxide concentrations on human bronchial reactivity and lung function. Eur J Respir Dis. 1985 Mar;66(3):205–217. [PubMed] [Google Scholar]
  32. Carson J. L., Collier A. M., Hu S., Smith C. A., Stewart P. The appearance of compound cilia in the nasal mucosa of normal human subjects following acute, in vivo exposure to sulfur dioxide. Environ Res. 1987 Feb;42(1):155–165. doi: 10.1016/s0013-9351(87)80017-8. [DOI] [PubMed] [Google Scholar]
  33. Coburn R. F., Forster R. E., Kane P. B. Considerations of the physiological variables that determine the blood carboxyhemoglobin concentration in man. J Clin Invest. 1965 Nov;44(11):1899–1910. doi: 10.1172/JCI105296. [DOI] [PMC free article] [PubMed] [Google Scholar]
  34. DEANE M., GOLDSMITH J. R., TUMA D. RESPIRATORY CONDITIONS IN OUTSIDE WORKERS. REPORT ON OUTSIDE PLANT TELEPHONE WORKERS IN SAN FRANCISCO AND LOS ANGELES. Arch Environ Health. 1965 Feb;10:323–331. doi: 10.1080/00039896.1965.10664003. [DOI] [PubMed] [Google Scholar]
  35. Davis J. M., Otto D. A., Weil D. E., Grant L. D. The comparative developmental neurotoxicity of lead in humans and animals. Neurotoxicol Teratol. 1990 May-Jun;12(3):215–229. doi: 10.1016/0892-0362(90)90093-r. [DOI] [PubMed] [Google Scholar]
  36. Davis J. M. Risk assessment of the developmental neurotoxicity of lead. Neurotoxicology. 1990 Summer;11(2):285–291. [PubMed] [Google Scholar]
  37. Detels R., Tashkin D. P., Sayre J. W., Rokaw S. N., Coulson A. H., Massey F. J., Jr, Wegman D. H. The UCLA population studies of chronic obstructive respiratory disease. 9. Lung function changes associated with chronic exposure to photochemical oxidants; a cohort study among never-smokers. Chest. 1987 Oct;92(4):594–603. doi: 10.1378/chest.92.4.594. [DOI] [PubMed] [Google Scholar]
  38. Devlin R. B., McDonnell W. F., Mann R., Becker S., House D. E., Schreinemachers D., Koren H. S. Exposure of humans to ambient levels of ozone for 6.6 hours causes cellular and biochemical changes in the lung. Am J Respir Cell Mol Biol. 1991 Jan;4(1):72–81. doi: 10.1165/ajrcmb/4.1.72. [DOI] [PubMed] [Google Scholar]
  39. Dimeo M. J., Glenn M. G., Holtzman M. J., Sheller J. R., Nadel J. A., Boushey H. A. Threshold concentration of ozone causing an increase in bronchial reactivity in humans and adaptation with repeated exposures. Am Rev Respir Dis. 1981 Sep;124(3):245–248. doi: 10.1164/arrd.1981.124.3.245. [DOI] [PubMed] [Google Scholar]
  40. Dockery D. W., Ware J. H., Ferris B. G., Jr, Speizer F. E., Cook N. R., Herman S. M. Change in pulmonary function in children associated with air pollution episodes. J Air Pollut Control Assoc. 1982 Sep;32(9):937–942. doi: 10.1080/00022470.1982.10465494. [DOI] [PubMed] [Google Scholar]
  41. Drechsler-Parks D. M., Bedi J. F., Horvath S. M. Pulmonary function responses of older men and women to ozone exposure. Exp Gerontol. 1987;22(2):91–101. doi: 10.1016/0531-5565(87)90044-1. [DOI] [PubMed] [Google Scholar]
  42. Easton R. E., Murphy S. D. Experimental ozone preexposure and histamine. Effect on the acute toxicity and respiratory function effects of histamine in guinea pigs. Arch Environ Health. 1967 Aug;15(2):160–166. doi: 10.1080/00039896.1967.10664897. [DOI] [PubMed] [Google Scholar]
  43. Ehrlich R., Findlay J. C., Fenters J. D., Gardner D. E. Health effects of short-term inhalation of nitrogen dioxide and ozone mixtures. Environ Res. 1977 Oct;14(2):223–231. doi: 10.1016/0013-9351(77)90034-2. [DOI] [PubMed] [Google Scholar]
  44. Ehrlich R., Henry M. C. Chronic toxicity of nitrogen dioxide. I. Effect on resistance to bacterial pneumonia. Arch Environ Health. 1968 Dec;17(6):860–865. doi: 10.1080/00039896.1968.10665342. [DOI] [PubMed] [Google Scholar]
  45. Evans T. W., Brokaw J. J., Chung K. F., Nadel J. A., McDonald D. M. Ozone-induced bronchial hyperresponsiveness in the rat is not accompanied by neutrophil influx or increased vascular permeability in the trachea. Am Rev Respir Dis. 1988 Jul;138(1):140–144. doi: 10.1164/ajrccm/138.1.140. [DOI] [PubMed] [Google Scholar]
  46. FRANK N. R., AMDUR M. O., WORCESTER J., WHITTENBERGER J. L. Effects of acute controlled exposure to SO2 on respiratory mechanics in healthy male adults. J Appl Physiol. 1962 Mar;17:252–258. doi: 10.1152/jappl.1962.17.2.252. [DOI] [PubMed] [Google Scholar]
  47. Fabbri L. M., Aizawa H., Alpert S. E., Walters E. H., O'Byrne P. M., Gold B. D., Nadel J. A., Holtzman M. J. Airway hyperresponsiveness and changes in cell counts in bronchoalveolar lavage after ozone exposure in dogs. Am Rev Respir Dis. 1984 Feb;129(2):288–291. [PubMed] [Google Scholar]
  48. Folinsbee L. J., Bedi J. F., Horvath S. M. Combined effects of ozone and nitrogen dioxide on respiratory function in man. Am Ind Hyg Assoc J. 1981 Jul;42(7):534–541. doi: 10.1080/15298668191420206. [DOI] [PubMed] [Google Scholar]
  49. Folinsbee L. J., Bedi J. F., Horvath S. M. Pulmonary function changes after 1 h continuous heavy exercise in 0.21 ppm ozone. J Appl Physiol Respir Environ Exerc Physiol. 1984 Oct;57(4):984–988. doi: 10.1152/jappl.1984.57.4.984. [DOI] [PubMed] [Google Scholar]
  50. Folinsbee L. J., Horvath S. M., Bedi J. F., Delehunt J. C. Effect of 0.62 ppm NO2 on cardiopulmonary function in young male nonsmokers. Environ Res. 1978 Apr;15(2):199–205. doi: 10.1016/0013-9351(78)90096-8. [DOI] [PubMed] [Google Scholar]
  51. Folinsbee L. J., Horvath S. M. Persistence of the acute effects of ozone exposure. Aviat Space Environ Med. 1986 Dec;57(12 Pt 1):1136–1143. [PubMed] [Google Scholar]
  52. Folinsbee L. J., McDonnell W. F., Horstman D. H. Pulmonary function and symptom responses after 6.6-hour exposure to 0.12 ppm ozone with moderate exercise. JAPCA. 1988 Jan;38(1):28–35. doi: 10.1080/08940630.1988.10466349. [DOI] [PubMed] [Google Scholar]
  53. Folinsbee L. J., Silverman F., Shepard R. J. Decrease of maximum work performance following ozone exposure. J Appl Physiol Respir Environ Exerc Physiol. 1977 Apr;42(4):531–536. doi: 10.1152/jappl.1977.42.4.531. [DOI] [PubMed] [Google Scholar]
  54. Folinsbee L. J., Silverman F., Shephard R. J. Exercise responses following ozone exposure. J Appl Physiol. 1975 Jun;38(6):996–1001. doi: 10.1152/jappl.1975.38.6.996. [DOI] [PubMed] [Google Scholar]
  55. Frampton M. W., Smeglin A. M., Roberts N. J., Jr, Finkelstein J. N., Morrow P. E., Utell M. J. Nitrogen dioxide exposure in vivo and human alveolar macrophage inactivation of influenza virus in vitro. Environ Res. 1989 Apr;48(2):179–192. doi: 10.1016/s0013-9351(89)80033-7. [DOI] [PubMed] [Google Scholar]
  56. Frank N. R., Yoder R. E., Brain J. D., Yokoyama E. SO2 (35S labeled) absorption by the nose and mouth under conditions of varying concentration and flow. Arch Environ Health. 1969 Mar;18(3):315–322. doi: 10.1080/00039896.1969.10665414. [DOI] [PubMed] [Google Scholar]
  57. Gardner D. E., Coffin D. L., Pinigin M. A., Sidorenko G. I. Role of time as a factor in the toxicity of chemical compounds in intermittent and continuous exposures. Part I. Effects of continuous exposure. J Toxicol Environ Health. 1977 Dec;3(5-6):811–820. doi: 10.1080/15287397709529615. [DOI] [PubMed] [Google Scholar]
  58. Gearhart J. M., Schlesinger R. B. Sulfuric acid-induced changes in the physiology and structure of the tracheobronchial airways. Environ Health Perspect. 1989 Feb;79:127–136. doi: 10.1289/ehp.8979127. [DOI] [PMC free article] [PubMed] [Google Scholar]
  59. Gerrity T. R., Weaver R. A., Berntsen J., House D. E., O'Neil J. J. Extrathoracic and intrathoracic removal of O3 in tidal-breathing humans. J Appl Physiol (1985) 1988 Jul;65(1):393–400. doi: 10.1152/jappl.1988.65.1.393. [DOI] [PubMed] [Google Scholar]
  60. Gong H., Jr, Bradley P. W., Simmons M. S., Tashkin D. P. Impaired exercise performance and pulmonary function in elite cyclists during low-level ozone exposure in a hot environment. Am Rev Respir Dis. 1986 Oct;134(4):726–733. doi: 10.1164/arrd.1986.134.4.726. [DOI] [PubMed] [Google Scholar]
  61. Graham D., Henderson F., House D. Neutrophil influx measured in nasal lavages of humans exposed to ozone. Arch Environ Health. 1988 May-Jun;43(3):228–233. doi: 10.1080/00039896.1988.9934938. [DOI] [PubMed] [Google Scholar]
  62. Graham J. A., Gardner D. E., Blommer E. J., House D. E., Ménache M. G., Miller F. J. Influence of exposure patterns of nitrogen dioxide and modifications by ozone on susceptibility to bacterial infectious disease in mice. J Toxicol Environ Health. 1987;21(1-2):113–125. doi: 10.1080/15287398709531006. [DOI] [PubMed] [Google Scholar]
  63. HALLETT W. Y. EFFECT OF OZONE AND CIGARETTE SMOKE ON LUNG FUNCTION. Arch Environ Health. 1965 Feb;10:295–302. doi: 10.1080/00039896.1965.10663999. [DOI] [PubMed] [Google Scholar]
  64. HAMMER D. I., PORTNOY B., MASSEY F. M., WAYNE W. S., OELSNER T., WEHRLE P. F. LOS ANGELES AIR POLLUTION AND RESPIRATORY SYMPTOMS. RELATIONSHIP DURING A SELECTED 28-DAY PERIOD. Arch Environ Health. 1965 Mar;10:475–480. doi: 10.1080/00039896.1965.10664031. [DOI] [PubMed] [Google Scholar]
  65. Hackney J. D., Linn W. S., Mohler J. G., Collier C. R. Adaptation to short-term respiratory effects of ozone in men exposed repeatedly. J Appl Physiol Respir Environ Exerc Physiol. 1977 Jul;43(1):82–85. doi: 10.1152/jappl.1977.43.1.82. [DOI] [PubMed] [Google Scholar]
  66. Haldane J. The Action of Carbonic Oxide on Man. J Physiol. 1895 Nov 16;18(5-6):430–462. doi: 10.1113/jphysiol.1895.sp000578. [DOI] [PMC free article] [PubMed] [Google Scholar]
  67. Hammer D. I., Hasselblad V., Portnoy B., Wehrle P. F. Los Angeles student nurse study. Daily symptom reporting and photochemical oxidants. Arch Environ Health. 1974 May;28(5):255–260. doi: 10.1080/00039896.1974.10666482. [DOI] [PubMed] [Google Scholar]
  68. Hawk B. A., Schroeder S. R., Robinson G., Otto D., Mushak P., Kleinbaum D., Dawson G. Relation of lead and social factors to IQ of low-SES children: a partial replication. Am J Ment Defic. 1986 Sep;91(2):178–183. [PubMed] [Google Scholar]
  69. Hazucha M. J., Bates D. V., Bromberg P. A. Mechanism of action of ozone on the human lung. J Appl Physiol (1985) 1989 Oct;67(4):1535–1541. doi: 10.1152/jappl.1989.67.4.1535. [DOI] [PubMed] [Google Scholar]
  70. Hazucha M., Bates D. V. Combined effect of ozone and sulphur dioxide on human pulmonary function. Nature. 1975 Sep 4;257(5521):50–51. doi: 10.1038/257050a0. [DOI] [PubMed] [Google Scholar]
  71. Hazucha M., Silverman F., Parent C., Field S., Bates D. V. Pulmonary function in man after short-term exposure to ozone. Arch Environ Health. 1973 Sep;27(3):183–188. doi: 10.1080/00039896.1973.10666349. [DOI] [PubMed] [Google Scholar]
  72. Hinderliter A. L., Adams K. F., Jr, Price C. J., Herbst M. C., Koch G., Sheps D. S. Effects of low-level carbon monoxide exposure on resting and exercise-induced ventricular arrhythmias in patients with coronary artery disease and no baseline ectopy. Arch Environ Health. 1989 Mar-Apr;44(2):89–93. doi: 10.1080/00039896.1989.9934381. [DOI] [PubMed] [Google Scholar]
  73. Holland G. J., Benson D., Bush A., Rich G. Q., Holland R. P. Air pollution simulation and human performance. Am J Public Health Nations Health. 1968 Sep;58(9):1684–1691. doi: 10.2105/ajph.58.9.1684. [DOI] [PMC free article] [PubMed] [Google Scholar]
  74. Holtzman M. J., Cunningham J. H., Sheller J. R., Irsigler G. B., Nadel J. A., Boushey H. A. Effect of ozone on bronchial reactivity in atopic and nonatopic subjects. Am Rev Respir Dis. 1979 Nov;120(5):1059–1067. doi: 10.1164/arrd.1979.120.5.1059. [DOI] [PubMed] [Google Scholar]
  75. Holtzman M. J., Fabbri L. M., O'Byrne P. M., Gold B. D., Aizawa H., Walters E. H., Alpert S. E., Nadel J. A. Importance of airway inflammation for hyperresponsiveness induced by ozone. Am Rev Respir Dis. 1983 Jun;127(6):686–690. doi: 10.1164/arrd.1983.127.6.686. [DOI] [PubMed] [Google Scholar]
  76. Horstman D. H., Folinsbee L. J., Ives P. J., Abdul-Salaam S., McDonnell W. F. Ozone concentration and pulmonary response relationships for 6.6-hour exposures with five hours of moderate exercise to 0.08, 0.10, and 0.12 ppm. Am Rev Respir Dis. 1990 Nov;142(5):1158–1163. doi: 10.1164/ajrccm/142.5.1158. [DOI] [PubMed] [Google Scholar]
  77. Horstman D. H., Seal E., Jr, Folinsbee L. J., Ives P., Roger L. J. The relationship between exposure duration and sulfur dioxide-induced bronchoconstriction in asthmatic subjects. Am Ind Hyg Assoc J. 1988 Jan;49(1):38–47. doi: 10.1080/15298668891379341. [DOI] [PubMed] [Google Scholar]
  78. Horvath S. M., Folinsbee L. J., Bedi J. F. Combined effect of ozone and sulfuric acid on pulmonary function in man. Am Ind Hyg Assoc J. 1987 Feb;48(2):94–98. doi: 10.1080/15298668791384454. [DOI] [PubMed] [Google Scholar]
  79. Horvath S. M., Gliner J. A., Folinsbee L. J. Adaptation to ozone: duration of effect. Am Rev Respir Dis. 1981 May;123(5):496–499. doi: 10.1164/arrd.1981.123.5.496. [DOI] [PubMed] [Google Scholar]
  80. Horvath S. M. Impact of air quality in exercise performance. Exerc Sport Sci Rev. 1981;9:265–296. [PubMed] [Google Scholar]
  81. Horvath S. M., Raven P. B., Dahms T. E., Gray D. J. Maximal aerobic capacity at different levels of carboxyhemoglobin. J Appl Physiol. 1975 Feb;38(2):300–303. doi: 10.1152/jappl.1975.38.2.300. [DOI] [PubMed] [Google Scholar]
  82. Hudnell H. K., Benignus V. A. Carbon monoxide exposure and human visual detection thresholds. Neurotoxicol Teratol. 1989 Jul-Aug;11(4):363–371. doi: 10.1016/0892-0362(89)90008-1. [DOI] [PubMed] [Google Scholar]
  83. Ito K. [Effect of nitrogen dioxide inhalation on influenza virus infection in mice]. Nihon Eiseigaku Zasshi. 1971 Aug;26(3):304–314. doi: 10.1265/jjh.26.304. [DOI] [PubMed] [Google Scholar]
  84. Kehrl H. R., Hazucha M. J., Solic J. J., Bromberg P. A. Responses of subjects with chronic obstructive pulmonary disease after exposures to 0.3 ppm ozone. Am Rev Respir Dis. 1985 May;131(5):719–724. doi: 10.1164/arrd.1985.131.5.719. [DOI] [PubMed] [Google Scholar]
  85. Kehrl H. R., Roger L. J., Hazucha M. J., Horstman D. H. Differing response of asthmatics to sulfur dioxide exposure with continuous and intermittent exercise. Am Rev Respir Dis. 1987 Feb;135(2):350–355. doi: 10.1164/arrd.1987.135.2.350. [DOI] [PubMed] [Google Scholar]
  86. Kehrl H. R., Vincent L. M., Kowalsky R. J., Horstman D. H., O'Neil J. J., McCartney W. H., Bromberg P. A. Ozone exposure increases respiratory epithelial permeability in humans. Am Rev Respir Dis. 1987 May;135(5):1124–1128. doi: 10.1164/arrd.1987.135.5.1124. [DOI] [PubMed] [Google Scholar]
  87. Kirkpatrick M. B., Sheppard D., Nadel J. A., Boushey H. A. Effect of the oronasal breathing route on sulfur dioxide-induced bronchoconstriction in exercising asthmatic subjects. Am Rev Respir Dis. 1982 Jun;125(6):627–631. doi: 10.1164/arrd.1982.125.6.627. [DOI] [PubMed] [Google Scholar]
  88. Koenig J. Q., Covert D. S., Hanley Q. S., van Belle G., Pierson W. E. Prior exposure to ozone potentiates subsequent response to sulfur dioxide in adolescent asthmatic subjects. Am Rev Respir Dis. 1990 Feb;141(2):377–380. doi: 10.1164/ajrccm/141.2.377. [DOI] [PubMed] [Google Scholar]
  89. Koenig J. Q., Covert D. S., Pierson W. E. Effects of inhalation of acidic compounds on pulmonary function in allergic adolescent subjects. Environ Health Perspect. 1989 Feb;79:173–178. doi: 10.1289/ehp.8979173. [DOI] [PMC free article] [PubMed] [Google Scholar]
  90. Koenig J. Q., Covert D. S., Smith M. S., van Belle G., Pierson W. E. The pulmonary effects of ozone and nitrogen dioxide alone and combined in healthy and asthmatic adolescent subjects. Toxicol Ind Health. 1988 Dec;4(4):521–532. doi: 10.1177/074823378800400410. [DOI] [PubMed] [Google Scholar]
  91. Koenig J. Q., Pierson W. E., Horike M., Frank R. Bronchoconstrictor responses to sulfur dioxide or sulfur dioxide plus sodium chloride droplets in allergic, nonasthmatic adolescent. J Allergy Clin Immunol. 1982 Apr;69(4):339–344. doi: 10.1016/0091-6749(82)90143-9. [DOI] [PubMed] [Google Scholar]
  92. Koenig J. Q., Pierson W. E., Horike M., Frank R. Effects of SO2 plus NaCl aerosol combined with moderate exercise on pulmonary function in asthmatic adolescents. Environ Res. 1981 Aug;25(2):340–348. doi: 10.1016/0013-9351(81)90036-0. [DOI] [PubMed] [Google Scholar]
  93. Koenig J. Q., Pierson W. E., Horike M. The effects of inhaled sulfuric acid on pulmonary function in adolescent asthmatics. Am Rev Respir Dis. 1983 Aug;128(2):221–225. doi: 10.1164/arrd.1983.128.2.221. [DOI] [PubMed] [Google Scholar]
  94. Koren H. S., Devlin R. B., Graham D. E., Mann R., McGee M. P., Horstman D. H., Kozumbo W. J., Becker S., House D. E., McDonnell W. F. Ozone-induced inflammation in the lower airways of human subjects. Am Rev Respir Dis. 1989 Feb;139(2):407–415. doi: 10.1164/ajrccm/139.2.407. [DOI] [PubMed] [Google Scholar]
  95. Kreisman H., Mitchell C. A., Hosein H. R., Bouhuys A. Effect of low concentrations of sulfur dioxide on respiratory function in man. Lung. 1976 Dec 29;154(1):25–34. doi: 10.1007/BF02713516. [DOI] [PubMed] [Google Scholar]
  96. Kreit J. W., Gross K. B., Moore T. B., Lorenzen T. J., D'Arcy J., Eschenbacher W. L. Ozone-induced changes in pulmonary function and bronchial responsiveness in asthmatics. J Appl Physiol (1985) 1989 Jan;66(1):217–222. doi: 10.1152/jappl.1989.66.1.217. [DOI] [PubMed] [Google Scholar]
  97. Kulle T. J., Kerr H. D., Farrell B. P., Sauder L. R., Bermel M. S. Pulmonary function and bronchial reactivity in human subjects with exposure to ozone and respirable sulfuric acid aerosol. Am Rev Respir Dis. 1982 Dec;126(6):996–1000. doi: 10.1164/arrd.1982.126.6.996. [DOI] [PubMed] [Google Scholar]
  98. Kulle T. J., Sauder L. R., Hebel J. R., Chatham M. D. Ozone response relationships in healthy nonsmokers. Am Rev Respir Dis. 1985 Jul;132(1):36–41. doi: 10.1164/arrd.1985.132.1.36. [DOI] [PubMed] [Google Scholar]
  99. Kulle T. J., Sauder L. R., Kerr H. D., Farrell B. P., Bermel M. S., Smith D. M. Duration of pulmonary function adaptation to ozone in humans. Am Ind Hyg Assoc J. 1982 Nov;43(11):832–837. doi: 10.1080/15298668291410657. [DOI] [PubMed] [Google Scholar]
  100. Landaw S. A. The effects of cigarette smoking on total body burden and excretion rates of carbon monoxide. J Occup Med. 1973 Mar;15(3):231–235. [PubMed] [Google Scholar]
  101. Larsen R. I., McDonnell W. F., Horstman D. H., Folinsbee L. J. An air quality data analysis system for interrelating effects, standards, and needed source reductions: Part 11. A lognormal model relating human lung function decrease to O3 exposure. J Air Waste Manage Assoc. 1991 Apr;41(4):455–459. doi: 10.1080/10473289.1991.10466858. [DOI] [PubMed] [Google Scholar]
  102. Larson T. V., Covert D. S., Frank R., Charlson R. J. Ammonia in the human airways: neutralization of inspired acid sulfate aerosols. Science. 1977 Jul 8;197(4299):161–163. doi: 10.1126/science.877545. [DOI] [PubMed] [Google Scholar]
  103. Lee L. Y., Bleecker E. R., Nadel J. A. Effect of ozone on bronchomotor response to inhaled histamine aerosol in dogs. J Appl Physiol Respir Environ Exerc Physiol. 1977 Oct;43(4):626–631. doi: 10.1152/jappl.1977.43.4.626. [DOI] [PubMed] [Google Scholar]
  104. Leikauf G. D., Driscoll K. E., Wey H. E. Ozone-induced augmentation of eicosanoid metabolism in epithelial cells from bovine trachea. Am Rev Respir Dis. 1988 Feb;137(2):435–442. doi: 10.1164/ajrccm/137.2.435. [DOI] [PubMed] [Google Scholar]
  105. Leikauf G. D., Spektor D. M., Albert R. E., Lippmann M. Dose-dependent effects of submicrometer sulfuric acid aerosol on particle clearance from ciliated human lung airways. Am Ind Hyg Assoc J. 1984 May;45(5):285–292. doi: 10.1080/15298668491399802. [DOI] [PubMed] [Google Scholar]
  106. Leikauf G., Yeates D. B., Wales K. A., Spektor D., Albert R. E., Lippmann M. Effects of sulfuric acid aerosol on respiratory mechanics and mucociliary particle clearance in healthy nonsmoking adults. Am Ind Hyg Assoc J. 1981 Apr;42(4):273–282. doi: 10.1080/15298668191419721. [DOI] [PubMed] [Google Scholar]
  107. Linn W. S., Avol E. L., Peng R. C., Shamoo D. A., Hackney J. D. Replicated dose-response study of sulfur dioxide effects in normal, atopic, and asthmatic volunteers. Am Rev Respir Dis. 1987 Nov;136(5):1127–1134. doi: 10.1164/ajrccm/136.5.1127. [DOI] [PubMed] [Google Scholar]
  108. Linn W. S., Avol E. L., Shamoo D. A., Peng R. C., Spier C. E., Smith M. N., Hackney J. D. Effect of metaproterenol sulfate on mild asthmatics' response to sulfur dioxide exposure and exercise. Arch Environ Health. 1988 Nov-Dec;43(6):399–406. doi: 10.1080/00039896.1988.9935858. [DOI] [PubMed] [Google Scholar]
  109. Linn W. S., Avol E. L., Shamoo D. A., Peng R. C., Valencia L. M., Little D. E., Hackney J. D. Repeated laboratory ozone exposures of volunteer Los Angeles residents: an apparent seasonal variation in response. Toxicol Ind Health. 1988 Dec;4(4):505–520. doi: 10.1177/074823378800400409. [DOI] [PubMed] [Google Scholar]
  110. Linn W. S., Avol E. L., Shamoo D. A., Venet T. G., Anderson K. R., Whynot J. D., Hackney J. D. Asthmatics' responses to 6-hr sulfur dioxide exposures on two successive days. Arch Environ Health. 1984 Jul-Aug;39(4):313–319. doi: 10.1080/00039896.1984.10545856. [DOI] [PubMed] [Google Scholar]
  111. Linn W. S., Buckley R. D., Spier C. E., Blessey R. L., Jones M. P., Fischer D. A., Hackney J. D. Health effects of ozone exposure in asthmatics. Am Rev Respir Dis. 1978 May;117(5):835–843. doi: 10.1164/arrd.1978.117.5.835. [DOI] [PubMed] [Google Scholar]
  112. Linn W. S., Medway D. A., Anzar U. T., Valencia L. M., Spier C. E., Tsao F. S., Fischer D. A., Hackney J. D. Persistence of adaptation to ozone in volunteers exposed repeatedly for six weeks. Am Rev Respir Dis. 1982 May;125(5):491–495. doi: 10.1164/arrd.1982.125.5.491. [DOI] [PubMed] [Google Scholar]
  113. Linn W. S., Venet T. G., Shamoo D. A., Valencia L. M., Anzar U. T., Spier C. E., Hackney J. D. Respiratory effects of sulfur dioxide in heavily exercising asthmatics. A dose-response study. Am Rev Respir Dis. 1983 Mar;127(3):278–283. doi: 10.1164/arrd.1983.127.3.278. [DOI] [PubMed] [Google Scholar]
  114. MARTIN A. E., BRADLEY W. H. Mortality, fog and atmospheric pollution: an investigation during the winter of 1958-59. Mon Bull Minist Health Public Health Lab Serv. 1960 May;19:56–72. [PubMed] [Google Scholar]
  115. McDonnell W. F., 3rd, Chapman R. S., Leigh M. W., Strope G. L., Collier A. M. Respiratory responses of vigorously exercising children to 0.12 ppm ozone exposure. Am Rev Respir Dis. 1985 Oct;132(4):875–879. doi: 10.1164/arrd.1985.132.4.875. [DOI] [PubMed] [Google Scholar]
  116. McDonnell W. F., 3rd, Horstman D. H., Abdul-Salaam S., House D. E. Reproducibility of individual responses to ozone exposure. Am Rev Respir Dis. 1985 Jan;131(1):36–40. doi: 10.1164/arrd.1985.131.S5.S36. [DOI] [PubMed] [Google Scholar]
  117. McDonnell W. F., Horstman D. H., Hazucha M. J., Seal E., Jr, Haak E. D., Salaam S. A., House D. E. Pulmonary effects of ozone exposure during exercise: dose-response characteristics. J Appl Physiol Respir Environ Exerc Physiol. 1983 May;54(5):1345–1352. doi: 10.1152/jappl.1983.54.5.1345. [DOI] [PubMed] [Google Scholar]
  118. Melia R. J., Florey C. D., Altman D. G., Swan A. V. Association between gas cooking and respiratory disease in children. Br Med J. 1977 Jul 16;2(6080):149–152. doi: 10.1136/bmj.2.6080.149. [DOI] [PMC free article] [PubMed] [Google Scholar]
  119. Miller F. J., Overton J. H., Jr, Jaskot R. H., Menzel D. B. A model of the regional uptake of gaseous pollutants in the lung. I. The sensitivity of the uptake of ozone in the human lung to lower respiratory tract secretions and exercise. Toxicol Appl Pharmacol. 1985 Jun 15;79(1):11–27. doi: 10.1016/0041-008x(85)90364-3. [DOI] [PubMed] [Google Scholar]
  120. Mohsenin V. Airway responses to 2.0 ppm nitrogen dioxide in normal subjects. Arch Environ Health. 1988 May-Jun;43(3):242–246. doi: 10.1080/00039896.1988.9934941. [DOI] [PubMed] [Google Scholar]
  121. Mohsenin V. Airway responses to nitrogen dioxide in asthmatic subjects. J Toxicol Environ Health. 1987;22(4):371–380. doi: 10.1080/15287398709531080. [DOI] [PubMed] [Google Scholar]
  122. Mumford J. L., He X. Z., Chapman R. S., Cao S. R., Harris D. B., Li X. M., Xian Y. L., Jiang W. Z., Xu C. W., Chuang J. C. Lung cancer and indoor air pollution in Xuan Wei, China. Science. 1987 Jan 9;235(4785):217–220. doi: 10.1126/science.3798109. [DOI] [PubMed] [Google Scholar]
  123. Murlas C. G., Roum J. H. Sequence of pathologic changes in the airway mucosa of guinea pigs during ozone-induced bronchial hyperreactivity. Am Rev Respir Dis. 1985 Mar;131(3):314–320. doi: 10.1164/arrd.1985.131.3.314. [DOI] [PubMed] [Google Scholar]
  124. Myers D. J., Bigby B. G., Boushey H. A. The inhibition of sulfur dioxide-induced bronchoconstriction in asthmatic subjects by cromolyn is dose dependent. Am Rev Respir Dis. 1986 Jun;133(6):1150–1153. doi: 10.1164/arrd.1986.133.6.1150. [DOI] [PubMed] [Google Scholar]
  125. NADEL J. A., SALEM H., TAMPLIN B., TOKIWA Y. MECHANISM OF BRONCHOCONSTRICTION DURING INHALATION OF SULFUR DIOXIDE. J Appl Physiol. 1965 Jan;20:164–167. doi: 10.1152/jappl.1965.20.1.164. [DOI] [PubMed] [Google Scholar]
  126. Neas L. M., Dockery D. W., Ware J. H., Spengler J. D., Speizer F. E., Ferris B. G., Jr Association of indoor nitrogen dioxide with respiratory symptoms and pulmonary function in children. Am J Epidemiol. 1991 Jul 15;134(2):204–219. doi: 10.1093/oxfordjournals.aje.a116073. [DOI] [PubMed] [Google Scholar]
  127. Needleman H. L., Gunnoe C., Leviton A., Reed R., Peresie H., Maher C., Barrett P. Deficits in psychologic and classroom performance of children with elevated dentine lead levels. N Engl J Med. 1979 Mar 29;300(13):689–695. doi: 10.1056/NEJM197903293001301. [DOI] [PubMed] [Google Scholar]
  128. Otto D. A., Benignus V. A., Muller K. E., Barton C. N. Effects of age and body lead burden on CNS function in young children. I. slow cortical potentials. Electroencephalogr Clin Neurophysiol. 1981 Oct;52(4):229–239. doi: 10.1016/0013-4694(81)90052-3. [DOI] [PubMed] [Google Scholar]
  129. Otto D. A., Benigus V. A., Prah J. D. Carbon monoxide and human time discrimination: failure to replicate Beard-Wertheim experiments. Aviat Space Environ Med. 1979 Jan;50(1):40–43. [PubMed] [Google Scholar]
  130. Otto D., Robinson G., Baumann S., Schroeder S., Mushak P., Kleinbaum D., Boone L. 5-year follow-up study of children with low-to-moderate lead absorption: electrophysiological evaluation. Environ Res. 1985 Oct;38(1):168–186. doi: 10.1016/0013-9351(85)90082-9. [DOI] [PubMed] [Google Scholar]
  131. Overton J. H., Graham R. C. Predictions of ozone absorption in human lungs from newborn to adult. Health Phys. 1989;57 (Suppl 1):29–36. doi: 10.1097/00004032-198907001-00003. [DOI] [PubMed] [Google Scholar]
  132. Pirkle J. L., Schwartz J., Landis J. R., Harlan W. R. The relationship between blood lead levels and blood pressure and its cardiovascular risk implications. Am J Epidemiol. 1985 Feb;121(2):246–258. doi: 10.1093/oxfordjournals.aje.a113995. [DOI] [PubMed] [Google Scholar]
  133. Pirnay F., Dujardin J., Deroanne R., Petit J. M. Muscular exercise during intoxication by carbon monoxide. J Appl Physiol. 1971 Oct;31(4):573–575. doi: 10.1152/jappl.1971.31.4.573. [DOI] [PubMed] [Google Scholar]
  134. Plopper C. G., Dungworth D. L., Tyler W. S. Pulmonary lesions in rats exposed to ozone. A correlated light and electron microscopic study. Am J Pathol. 1973 Jun;71(3):375–394. [PMC free article] [PubMed] [Google Scholar]
  135. Pope C. A., 3rd, Dockery D. W., Spengler J. D., Raizenne M. E. Respiratory health and PM10 pollution. A daily time series analysis. Am Rev Respir Dis. 1991 Sep;144(3 Pt 1):668–674. doi: 10.1164/ajrccm/144.3_Pt_1.668. [DOI] [PubMed] [Google Scholar]
  136. Pope C. A., 3rd Respiratory disease associated with community air pollution and a steel mill, Utah Valley. Am J Public Health. 1989 May;79(5):623–628. doi: 10.2105/ajph.79.5.623. [DOI] [PMC free article] [PubMed] [Google Scholar]
  137. Pope C. A., 3rd Respiratory hospital admissions associated with PM10 pollution in Utah, Salt Lake, and Cache Valleys. Arch Environ Health. 1991 Mar-Apr;46(2):90–97. doi: 10.1080/00039896.1991.9937434. [DOI] [PubMed] [Google Scholar]
  138. Roger L. J., Horstman D. H., McDonnell W., Kehrl H., Ives P. J., Seal E., Chapman R., Massaro E. Pulmonary function, airway responsiveness, and respiratory symptoms in asthmatics following exercise in NO2. Toxicol Ind Health. 1990 Jan;6(1):155–171. doi: 10.1177/074823379000600110. [DOI] [PubMed] [Google Scholar]
  139. Roger L. J., Kehrl H. R., Hazucha M., Horstman D. H. Bronchoconstriction in asthmatics exposed to sulfur dioxide during repeated exercise. J Appl Physiol (1985) 1985 Sep;59(3):784–791. doi: 10.1152/jappl.1985.59.3.784. [DOI] [PubMed] [Google Scholar]
  140. Roughton F. J. The equilibrium of carbon monoxide with human hemoglobin in whole blood. Ann N Y Acad Sci. 1970 Oct 5;174(1):177–188. doi: 10.1111/j.1749-6632.1970.tb49784.x. [DOI] [PubMed] [Google Scholar]
  141. SCHEEL L. D., DOBROGORSKI O. J., MOUNTAIN J. T., SVIRBELY J. L., STOKINGER H. E. Physiologic, biochemical, immunologic and pathologic changes following ozone exposure. J Appl Physiol. 1959 Jan;14(1):67–80. doi: 10.1152/jappl.1959.14.1.67. [DOI] [PubMed] [Google Scholar]
  142. STOKINGER H. E., WAGNER W. D., WRIGHT P. G. Studies of ozone toxicity. I. Potentiating effects of exercise and tolerance development. AMA Arch Ind Health. 1956 Aug;14(2):158–162. [PubMed] [Google Scholar]
  143. Schelegle E. S., Adams W. C., Giri S. N., Siefkin A. D. Acute ozone exposure increases plasma prostaglandin F2 alpha in ozone-sensitive human subjects. Am Rev Respir Dis. 1989 Jul;140(1):211–216. doi: 10.1164/ajrccm/140.1.211. [DOI] [PubMed] [Google Scholar]
  144. Schelegle E. S., Adams W. C. Reduced exercise time in competitive simulations consequent to low level ozone exposure. Med Sci Sports Exerc. 1986 Aug;18(4):408–414. [PubMed] [Google Scholar]
  145. Schelegle E. S., Adams W. C., Siefkin A. D. Indomethacin pretreatment reduces ozone-induced pulmonary function decrements in human subjects. Am Rev Respir Dis. 1987 Dec;136(6):1350–1354. doi: 10.1164/ajrccm/136.6.1350. [DOI] [PubMed] [Google Scholar]
  146. Schlesinger R. B. Effects of intermittent inhalation exposures to mixed atmospheres of NO2 and H2SO4 on rabbit alveolar macrophages. J Toxicol Environ Health. 1987;22(3):301–312. doi: 10.1080/15287398709531073. [DOI] [PubMed] [Google Scholar]
  147. Schwartz J., Angle C., Pitcher H. Relationship between childhood blood lead levels and stature. Pediatrics. 1986 Mar;77(3):281–288. [PubMed] [Google Scholar]
  148. Schwartz J., Dockery D. W. Increased mortality in Philadelphia associated with daily air pollution concentrations. Am Rev Respir Dis. 1992 Mar;145(3):600–604. doi: 10.1164/ajrccm/145.3.600. [DOI] [PubMed] [Google Scholar]
  149. Schwartz J., Marcus A. Mortality and air pollution in London: a time series analysis. Am J Epidemiol. 1990 Jan;131(1):185–194. doi: 10.1093/oxfordjournals.aje.a115473. [DOI] [PubMed] [Google Scholar]
  150. Schwartz J., Otto D. Blood lead, hearing thresholds, and neurobehavioral development in children and youth. Arch Environ Health. 1987 May-Jun;42(3):153–160. doi: 10.1080/00039896.1987.9935814. [DOI] [PubMed] [Google Scholar]
  151. Seltzer J., Bigby B. G., Stulbarg M., Holtzman M. J., Nadel J. A., Ueki I. F., Leikauf G. D., Goetzl E. J., Boushey H. A. O3-induced change in bronchial reactivity to methacholine and airway inflammation in humans. J Appl Physiol (1985) 1986 Apr;60(4):1321–1326. doi: 10.1152/jappl.1986.60.4.1321. [DOI] [PubMed] [Google Scholar]
  152. Seppäläinen A. M., Hernberg S., Vesanto R., Kock B. Early neurotoxic effects of occupational lead exposure: a prospective study. Neurotoxicology. 1983 Summer;4(2):181–192. [PubMed] [Google Scholar]
  153. Sheppard D., Epstein J., Bethel R. A., Nadel J. A., Boushey H. A. Tolerance to sulfur dioxide-induced bronchoconstriction in subjects with asthma. Environ Res. 1983 Apr;30(2):412–419. doi: 10.1016/0013-9351(83)90227-x. [DOI] [PubMed] [Google Scholar]
  154. Sheppard D., Eschenbacher W. L., Boushey H. A., Bethel R. A. Magnitude of the interaction between the bronchomotor effects of sulfur dioxide and those of dry (cold) air. Am Rev Respir Dis. 1984 Jul;130(1):52–55. doi: 10.1164/arrd.1984.130.1.52. [DOI] [PubMed] [Google Scholar]
  155. Sheppard D., Nadel J. A., Boushey H. A. Inhibition of sulfur dioxide-induced bronchoconstriction by disodium cromoglycate in asthmatic subjects. Am Rev Respir Dis. 1981 Sep;124(3):257–259. doi: 10.1164/arrd.1981.124.3.257. [DOI] [PubMed] [Google Scholar]
  156. Sheppard D., Saisho A., Nadel J. A., Boushey H. A. Exercise increases sulfur dioxide-induced bronchoconstriction in asthmatic subjects. Am Rev Respir Dis. 1981 May;123(5):486–491. doi: 10.1164/arrd.1981.123.5.486. [DOI] [PubMed] [Google Scholar]
  157. Sheppard D., Wong W. S., Uehara C. F., Nadel J. A., Boushey H. A. Lower threshold and greater bronchomotor responsiveness of asthmatic subjects to sulfur dioxide. Am Rev Respir Dis. 1980 Dec;122(6):873–878. doi: 10.1164/arrd.1980.122.6.873. [DOI] [PubMed] [Google Scholar]
  158. Sheps D. S., Adams K. F., Jr, Bromberg P. A., Goldstein G. M., O'Neil J. J., Horstman D., Koch G. Lack of effect of low levels of carboxyhemoglobin on cardiovascular function in patients with ischemic heart disease. Arch Environ Health. 1987 Mar-Apr;42(2):108–116. doi: 10.1080/00039896.1987.9935805. [DOI] [PubMed] [Google Scholar]
  159. Sheps D. S., Herbst M. C., Hinderliter A. L., Adams K. F., Ekelund L. G., O'Neil J. J., Goldstein G. M., Bromberg P. A., Dalton J. L., Ballenger M. N. Production of arrhythmias by elevated carboxyhemoglobin in patients with coronary artery disease. Ann Intern Med. 1990 Sep 1;113(5):343–351. doi: 10.7326/0003-4819-113-5-343. [DOI] [PubMed] [Google Scholar]
  160. Silverman F., Folinsbee L. J., Barnard J., Shephard R. J. Pulmonary function changes in ozone-interaction of concentration and ventilation. J Appl Physiol. 1976 Dec;41(6):859–864. doi: 10.1152/jappl.1976.41.6.859. [DOI] [PubMed] [Google Scholar]
  161. Speizer F. E., Frank N. R. A comparison of changes in pulmonary flow resistance in healthy volunteers acutely exposed to SO-2 by mouth and by nose. Br J Ind Med. 1966 Jan;23(1):75–79. doi: 10.1136/oem.23.1.75. [DOI] [PMC free article] [PubMed] [Google Scholar]
  162. Spektor D. M., Lippmann M., Lioy P. J., Thurston G. D., Citak K., James D. J., Bock N., Speizer F. E., Hayes C. Effects of ambient ozone on respiratory function in active, normal children. Am Rev Respir Dis. 1988 Feb;137(2):313–320. doi: 10.1164/ajrccm/137.2.313. [DOI] [PubMed] [Google Scholar]
  163. Spektor D. M., Yen B. M., Lippmann M. Effect of concentration and cumulative exposure of inhaled sulfuric acid on tracheobronchial particle clearance in healthy humans. Environ Health Perspect. 1989 Feb;79:167–172. doi: 10.1289/ehp.8979167. [DOI] [PMC free article] [PubMed] [Google Scholar]
  164. Stacy R. W., Seal E., Jr, House D. E., Green J., Roger L. J., Raggio L. A survey of effects of gaseous and aerosol pollutants on pulmonary function of normal males. Arch Environ Health. 1983 Mar-Apr;38(2):104–115. doi: 10.1080/00039896.1983.10543989. [DOI] [PubMed] [Google Scholar]
  165. Stern F. B., Halperin W. E., Hornung R. W., Ringenburg V. L., McCammon C. S. Heart disease mortality among bridge and tunnel officers exposed to carbon monoxide. Am J Epidemiol. 1988 Dec;128(6):1276–1288. doi: 10.1093/oxfordjournals.aje.a115081. [DOI] [PubMed] [Google Scholar]
  166. Tam E. K., Liu J., Bigby B. G., Boushey H. A. Sulfur dioxide does not acutely increase nasal symptoms or nasal resistance in subjects with rhinitis or in subjects with bronchial responsiveness to sulfur dioxide. Am Rev Respir Dis. 1988 Dec;138(6):1559–1564. doi: 10.1164/ajrccm/138.6.1559. [DOI] [PubMed] [Google Scholar]
  167. Tan W. C., Cripps E., Douglas N., Sudlow M. F. Protective effect of drugs on bronchoconstriction induced by sulphur dioxide. Thorax. 1982 Sep;37(9):671–675. doi: 10.1136/thx.37.9.671. [DOI] [PMC free article] [PubMed] [Google Scholar]
  168. Tepper J. S., Costa D. L., Lehmann J. R., Weber M. F., Hatch G. E. Unattenuated structural and biochemical alterations in the rat lung during functional adaptation to ozone. Am Rev Respir Dis. 1989 Aug;140(2):493–501. doi: 10.1164/ajrccm/140.2.493. [DOI] [PubMed] [Google Scholar]
  169. Traystman R. J., Fitzgerald R. S., Loscutoff S. C. Cerebral circulatory responses to arterial hypoxia in normal and chemodenervated dogs. Circ Res. 1978 May;42(5):649–657. doi: 10.1161/01.res.42.5.649. [DOI] [PubMed] [Google Scholar]
  170. Tyler W. S., Tyler N. K., Last J. A., Gillespie M. J., Barstow T. J. Comparison of daily and seasonal exposures of young monkeys to ozone. Toxicology. 1988 Jul;50(2):131–144. doi: 10.1016/0300-483x(88)90086-8. [DOI] [PubMed] [Google Scholar]
  171. Utell M. J., Morrow P. E., Hyde R. W. Airway reactivity to sulfate and sulfuric acid aerosols in normal and asthmatic subjects. J Air Pollut Control Assoc. 1984 Sep;34(9):931–935. doi: 10.1080/00022470.1984.10465838. [DOI] [PubMed] [Google Scholar]
  172. Vogel J. A., Gleser M. A. Effect of carbon monoxide on oxygen transport during exercise. J Appl Physiol. 1972 Feb;32(2):234–239. doi: 10.1152/jappl.1972.32.2.234. [DOI] [PubMed] [Google Scholar]
  173. Ware J. H., Ferris B. G., Jr, Dockery D. W., Spengler J. D., Stram D. O., Speizer F. E. Effects of ambient sulfur oxides and suspended particles on respiratory health of preadolescent children. Am Rev Respir Dis. 1986 May;133(5):834–842. [PubMed] [Google Scholar]
  174. Weiss S. T., Muñoz A., Stein A., Sparrow D., Speizer F. E. The relationship of blood lead to blood pressure in a longitudinal study of working men. Am J Epidemiol. 1986 May;123(5):800–808. doi: 10.1093/oxfordjournals.aje.a114309. [DOI] [PubMed] [Google Scholar]
  175. Whittemore A. S., Korn E. L. Asthma and air pollution in the Los Angeles area. Am J Public Health. 1980 Jul;70(7):687–696. doi: 10.2105/ajph.70.7.687. [DOI] [PMC free article] [PubMed] [Google Scholar]
  176. Wiester M. J., Tepper J. S., King M. E., Ménache M. G., Costa D. L. Comparative study of ozone (O3) uptake in three strains of rats and in the guinea pig. Toxicol Appl Pharmacol. 1988 Oct;96(1):140–146. doi: 10.1016/0041-008x(88)90256-6. [DOI] [PubMed] [Google Scholar]
  177. Witek T. J., Jr, Schachter E. N. Airway responses to sulfur dioxide and methacholine in asthmatics. J Occup Med. 1985 Apr;27(4):265–268. [PubMed] [Google Scholar]
  178. YOUNG W. A., SHAW D. B., BATES D. V. EFFECT OF LOW CONCENTRATIONS OF OZONE ON PULMONARY FUNCTION IN MAN. J Appl Physiol. 1964 Jul;19:765–768. doi: 10.1152/jappl.1964.19.4.765. [DOI] [PubMed] [Google Scholar]
  179. YOUNG W. A., SHAW D. B., BATES D. V. PULMONARY FUNCTION IN WELDERS EXPOSED TO OZONE. Arch Environ Health. 1963 Sep;7:337–340. doi: 10.1080/00039896.1963.10663542. [DOI] [PubMed] [Google Scholar]

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