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. 1951 Dec;75(6):385–391.

DIAGNOSIS OF PULMONARY COCCIDIOIDAL INFECTIONS

Charles E Smith
PMCID: PMC1521097  PMID: 14886741

Abstract

A wide variety of pulmonary lesions may be caused by coccidioidomycosis. Suspicion of coccidioidomycosis may be substantiated by careful clinical-epidemiological histories. The first laboratory procedure should be a coccidioidin skin test. If the reaction to the test is positive, serological tests are next. Also, if there is no reaction to coccidioidin, serological tests are still indicated if dissemination is suspected. The more severe the infection, the greater the probability of establishing a diagnosis serologically. In only three-fifths of patients with coccidioidal cavities can the diagnosis be fixed serologically. In such patients if differential skin tests are not conclusive, attempt should be made to recover the fungus. However, this is accompanied by great risk of laboratory infection. Eosinophilia and accelerated erythrocyte sedimentation are only circumstantial items of evidence, as is the appearance of the pulmonary roentgenogram.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. GOMEZ R. F. Endemism of Coccidioidomycosis in the Paraguayan Chaco. Calif Med. 1950 Jul;73(1):35–38. [PMC free article] [PubMed] [Google Scholar]
  2. Hurwitz S., Young J. E., Eddie B. U. Coccidioides Immitis Intradermal Skin Reaction: A Preliminary Report of 449 Cases. Cal West Med. 1938 Feb;48(2):87–89. [PMC free article] [PubMed] [Google Scholar]
  3. KESSEL J. F., BIDDLE M., TUCKER H. A., YEAMAN A. The distribution of coccidioidomycosis in Southern California. Calif Med. 1950 Oct;73(4):317–321. [PMC free article] [PubMed] [Google Scholar]
  4. KRITZER M. D., BIDDLE M., KESSEL J. F. An outbreak of primary pulmonary coccidioidomycosis in Los Angeles County, California. Ann Intern Med. 1950 Oct;33(4):960–990. doi: 10.7326/0003-4819-33-4-960. [DOI] [PubMed] [Google Scholar]
  5. LOONEY J. M., STEIN T. Coccidioidomycosis; the hazard involved in diagnostic procedures, with report of a case. N Engl J Med. 1950 Jan 19;242(3):77-82, illust. doi: 10.1056/NEJM195001192420301. [DOI] [PubMed] [Google Scholar]
  6. SCHWARZ J., MUTH J. Coccidiomycocis: a review. Am J Med Sci. 1951 Jan;221(1):89–107. doi: 10.1097/00000441-195101000-00013. [DOI] [PubMed] [Google Scholar]
  7. SMITH C. E., SAITO M. T., BEARD R. R., KEPP R. M., CLARK R. W., EDDIE B. U. Serological tests in the diagnosis and prognosis of coccidioidomycosis. Am J Hyg. 1950 Jul;52(1):1–21. doi: 10.1093/oxfordjournals.aje.a119404. [DOI] [PubMed] [Google Scholar]
  8. SMITH C. E., SAITO M. T. Histoplasmin sensitivity and coccidioidal infection; occurrence of cross-reaction. Am J Public Health Nations Health. 1949 Jun;39(6):722–736. doi: 10.2105/ajph.39.6.722. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Smith C. E. Epidemiology of Acute Coccidioidomycosis with Erythema Nodosum ("San Joaquin" or "Valley Fever"). Am J Public Health Nations Health. 1940 Jun;30(6):600–611. doi: 10.2105/ajph.30.6.600. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Smith C. E. MEDICAL PROGRESS: RECENT PROGRESS IN PULMONARY MYCOTIC INFECTIONS. Calif Med. 1947 Sep;67(3):179–185. [PMC free article] [PubMed] [Google Scholar]
  11. VAUGHAN J. E., RAMIREZ H. Coccidioidomycosis as a complication of pregnancy. Calif Med. 1951 Feb;74(2):121–125. [PMC free article] [PubMed] [Google Scholar]

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