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. 1956 Jul;85(1):30–32.

SEROLOGIC DIAGNOSIS OF SYPHILIS—The Use of Treponema Pallidum Immobilization and Immune Adherence Tests

Charles M Carpenter, Ruth A Boak, James N Miller
PMCID: PMC1532167  PMID: 13343001

Abstract

TPI tests were carried out on 4,060 sera. Among 3,934 patients with reactive STS and no history of syphilis, 2,148 or 54.6 per cent had negative reaction to TPI tests, 1,695 or 43.1 per cent had positive reaction and 91 or 2.3 per cent had doubtful reaction.

Two hundred and ninety-two or 73.0 per cent of 400 pregnant women with reaction to STS in the absence of a history of syphilis showed negative results by TPI test, 103 or 25.8 per cent had positive results and five or 1.2 per cent had doubtful reaction.

Ninety-five or 75.4 per cent of 126 patients with a history of treated syphilis had positive reaction to TPI tests, 20 or 20.2 per cent had negative reaction and nine or 9.1 per cent had doubtful reaction.

TPI and TPIA tests were done on 143 sera carefully selected for the study. Among 102 sera subjected to the TPI test, 46 or 100 per cent of these positive were also positive by TPIA tests, while 52 or 94.5 per cent of 55 TPI-negative sera were also nonreactive by TPIA test. One serum gave doubtful TPI test reaction and positive TPIA test reaction.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BOAK R. A., CARPENTER C. M., MILLER J. N., DRUSCH H. E., CHAPMAN J. M., HEIDBREDER G. A. Biologic false positive reactions for syphilis in pregnancy as determined by the Treponema pallidum immobilization test. Surg Gynecol Obstet. 1955 Dec;101(6):751–752. [PubMed] [Google Scholar]
  2. BOAK R. A., MILLER J. N. A simple medium for maintaining the viability of Treponema pallidum in the Treponema pallidum immobilization test. Am J Syph Gonorrhea Vener Dis. 1954 Sep;38(5):429–433. [PubMed] [Google Scholar]
  3. MILLER J. L., SLATKIN M. H., LUPTON E. S., BRODEY M. Studies on the value of the TPI test in the diagnosis of syphilis. Am J Syph Gonorrhea Vener Dis. 1952 Nov;36(6):559–565. [PubMed] [Google Scholar]
  4. MOHR C. F., MOORE J. E., NELSON R. A., HILL J. H. Studies on the relationship of treponemal antibody to probable biologic false positive serologic tests for syphilis. Am J Syph Gonorrhea Vener Dis. 1950 Sep 5;34(5):405–409. [PubMed] [Google Scholar]
  5. NELSON R. A., Jr The immune-adherence phenomenon; an immunologically specific reaction between microorganisms and erythrocytes leading to enhanced phagocytosis. Science. 1953 Dec 18;118(3077):733–737. doi: 10.1126/science.118.3077.733. [DOI] [PubMed] [Google Scholar]
  6. NELSON R. A., Jr, ZHEUTLIN E. C. Studies on treponemal immobilizing antibodies in syphilis; incidence in serum and cerebrospinal fluid in human beings and absence in biologic false positive reactors. Am J Syph Gonorrhea Vener Dis. 1950 Mar;34(2):101–121. [PubMed] [Google Scholar]

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