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. 1995 Apr;100(1):4–6. doi: 10.1111/j.1365-2249.1995.tb03595.x

The potential role of superantigens in inflammatory bowel disease.

R A Kay
PMCID: PMC1534254  PMID: 7697920

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abe J., Kotzin B. L., Jujo K., Melish M. E., Glode M. P., Kohsaka T., Leung D. Y. Selective expansion of T cells expressing T-cell receptor variable regions V beta 2 and V beta 8 in Kawasaki disease. Proc Natl Acad Sci U S A. 1992 May 1;89(9):4066–4070. doi: 10.1073/pnas.89.9.4066. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Abe J., Kotzin B. L., Meissner C., Melish M. E., Takahashi M., Fulton D., Romagne F., Malissen B., Leung D. Y. Characterization of T cell repertoire changes in acute Kawasaki disease. J Exp Med. 1993 Mar 1;177(3):791–796. doi: 10.1084/jem.177.3.791. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Acha-Orbea H., Palmer E. Mls--a retrovirus exploits the immune system. Immunol Today. 1991 Oct;12(10):356–361. doi: 10.1016/0167-5699(91)90066-3. [DOI] [PubMed] [Google Scholar]
  4. Acha-Orbea H., Shakhov A. N., Scarpellino L., Kolb E., Müller V., Vessaz-Shaw A., Fuchs R., Blöchlinger K., Rollini P., Billotte J. Clonal deletion of V beta 14-bearing T cells in mice transgenic for mammary tumour virus. Nature. 1991 Mar 21;350(6315):207–211. doi: 10.1038/350207a0. [DOI] [PubMed] [Google Scholar]
  5. Acha-Orbea H., Waanders G. A., Shakhov A. N., Held W. Infectious minor lymphocyte stimulating (Mls) antigens. Semin Immunol. 1992 Oct;4(5):297–303. [PubMed] [Google Scholar]
  6. Aisenberg J., Ebert E. C., Mayer L. T-cell activation in human intestinal mucosa: the role of superantigens. Gastroenterology. 1993 Nov;105(5):1421–1430. doi: 10.1016/0016-5085(93)90147-5. [DOI] [PubMed] [Google Scholar]
  7. Baca-Estrada M. E., Wong D. K., Croitoru K. Cytotoxic activity of V beta 8+ T cells in Crohn's disease: the role of bacterial superantigens. Clin Exp Immunol. 1995 Mar;99(3):398–403. doi: 10.1111/j.1365-2249.1995.tb05564.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Beharka A. A., Armstrong J. W., Iandolo J. J., Chapes S. K. Binding and activation of major histocompatibility complex class II-deficient macrophages by staphylococcal exotoxins. Infect Immun. 1994 Sep;62(9):3907–3915. doi: 10.1128/iai.62.9.3907-3915.1994. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Braunstein N. S., Weber D. A., Wang X. C., Long E. O., Karp D. Sequences in both class II major histocompatibility complex alpha and beta chains contribute to the binding of the superantigen toxic shock syndrome toxin 1. J Exp Med. 1992 May 1;175(5):1301–1305. doi: 10.1084/jem.175.5.1301. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Choi Y. W., Kotzin B., Herron L., Callahan J., Marrack P., Kappler J. Interaction of Staphylococcus aureus toxin "superantigens" with human T cells. Proc Natl Acad Sci U S A. 1989 Nov;86(22):8941–8945. doi: 10.1073/pnas.86.22.8941. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Choi Y., Kappler J. W., Marrack P. A superantigen encoded in the open reading frame of the 3' long terminal repeat of mouse mammary tumour virus. Nature. 1991 Mar 21;350(6315):203–207. doi: 10.1038/350203a0. [DOI] [PubMed] [Google Scholar]
  12. Choi Y., Lafferty J. A., Clements J. R., Todd J. K., Gelfand E. W., Kappler J., Marrack P., Kotzin B. L. Selective expansion of T cells expressing V beta 2 in toxic shock syndrome. J Exp Med. 1990 Sep 1;172(3):981–984. doi: 10.1084/jem.172.3.981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Clarke G. R., Reyburn H., Lancaster F. C., Boylston A. W. Bimodal distribution of V beta 2+CD4+ T cells in human peripheral blood. Eur J Immunol. 1994 Apr;24(4):837–842. doi: 10.1002/eji.1830240410. [DOI] [PubMed] [Google Scholar]
  14. Dadaglio G., Garcia S., Montagnier L., Gougeon M. L. Selective anergy of V beta 8+ T cells in human immunodeficiency virus-infected individuals. J Exp Med. 1994 Feb 1;179(2):413–424. doi: 10.1084/jem.179.2.413. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Dellabona P., Peccoud J., Kappler J., Marrack P., Benoist C., Mathis D. Superantigens interact with MHC class II molecules outside of the antigen groove. Cell. 1990 Sep 21;62(6):1115–1121. doi: 10.1016/0092-8674(90)90388-u. [DOI] [PubMed] [Google Scholar]
  16. Gahm S. J., Fowlkes B. J., Jameson S. C., Gascoigne N. R., Cotterman M. M., Kanagawa O., Schwartz R. H., Matis L. A. Profound alteration in an alpha beta T-cell antigen receptor repertoire due to polymorphism in the first complementarity-determining region of the beta chain. Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10267–10271. doi: 10.1073/pnas.88.22.10267. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Gascoigne N. R. Interaction of the T cell receptor with bacterial superantigens. Semin Immunol. 1993 Feb;5(1):13–21. doi: 10.1006/smim.1993.1003. [DOI] [PubMed] [Google Scholar]
  18. Go C., Lancki D. W., Fitch F. W., Miller J. Anergized T cell clones retain their cytolytic ability. J Immunol. 1993 Jan 15;150(2):367–376. [PubMed] [Google Scholar]
  19. Herman A., Croteau G., Sekaly R. P., Kappler J., Marrack P. HLA-DR alleles differ in their ability to present staphylococcal enterotoxins to T cells. J Exp Med. 1990 Sep 1;172(3):709–717. doi: 10.1084/jem.172.3.709. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Herman A., Kappler J. W., Marrack P., Pullen A. M. Superantigens: mechanism of T-cell stimulation and role in immune responses. Annu Rev Immunol. 1991;9:745–772. doi: 10.1146/annurev.iy.09.040191.003525. [DOI] [PubMed] [Google Scholar]
  21. Herman A., Labrecque N., Thibodeau J., Marrack P., Kappler J. W., Sekaly R. P. Identification of the staphylococcal enterotoxin A superantigen binding site in the beta 1 domain of the human histocompatibility antigen HLA-DR. Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):9954–9958. doi: 10.1073/pnas.88.22.9954. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Hudson K. R., Robinson H., Fraser J. D. Two adjacent residues in staphylococcal enterotoxins A and E determine T cell receptor V beta specificity. J Exp Med. 1993 Jan 1;177(1):175–184. doi: 10.1084/jem.177.1.175. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Hügin A. W., Vacchio M. S., Morse H. C., 3rd A virus-encoded "superantigen" in a retrovirus-induced immunodeficiency syndrome of mice. Science. 1991 Apr 19;252(5004):424–427. doi: 10.1126/science.1850169. [DOI] [PubMed] [Google Scholar]
  24. Ignatowicz L., Kappler J., Marrack P. The effects of chronic infection with a superantigen-producing virus. J Exp Med. 1992 Apr 1;175(4):917–923. doi: 10.1084/jem.175.4.917. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Jardetzky T. S., Brown J. H., Gorga J. C., Stern L. J., Urban R. G., Chi Y. I., Stauffacher C., Strominger J. L., Wiley D. C. Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen. Nature. 1994 Apr 21;368(6473):711–718. doi: 10.1038/368711a0. [DOI] [PubMed] [Google Scholar]
  26. Jett M., Brinkley W., Neill R., Gemski P., Hunt R. Staphylococcus aureus enterotoxin B challenge of monkeys: correlation of plasma levels of arachidonic acid cascade products with occurrence of illness. Infect Immun. 1990 Nov;58(11):3494–3499. doi: 10.1128/iai.58.11.3494-3499.1990. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Jorgensen J. L., Reay P. A., Ehrich E. W., Davis M. M. Molecular components of T-cell recognition. Annu Rev Immunol. 1992;10:835–873. doi: 10.1146/annurev.iy.10.040192.004155. [DOI] [PubMed] [Google Scholar]
  28. Kawabe Y., Ochi A. Selective anergy of V beta 8+,CD4+ T cells in Staphylococcus enterotoxin B-primed mice. J Exp Med. 1990 Oct 1;172(4):1065–1070. doi: 10.1084/jem.172.4.1065. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Labrecque N., Thibodeau J., Sékaly R. P. Interactions between staphylococcal superantigens and MHC class II molecules. Semin Immunol. 1993 Feb;5(1):23–32. doi: 10.1006/smim.1993.1004. [DOI] [PubMed] [Google Scholar]
  30. Leung D. Y., Meissner H. C., Fulton D. R., Murray D. L., Kotzin B. L., Schlievert P. M. Toxic shock syndrome toxin-secreting Staphylococcus aureus in Kawasaki syndrome. Lancet. 1993 Dec 4;342(8884):1385–1388. doi: 10.1016/0140-6736(93)92752-f. [DOI] [PubMed] [Google Scholar]
  31. Marrack P., Kappler J. The staphylococcal enterotoxins and their relatives. Science. 1990 May 11;248(4956):705–711. doi: 10.1126/science.2185544. [DOI] [PubMed] [Google Scholar]
  32. Micusan V. V., Thibodeau J. Superantigens of microbial origin. Semin Immunol. 1993 Feb;5(1):3–11. doi: 10.1006/smim.1993.1002. [DOI] [PubMed] [Google Scholar]
  33. Mollick J. A., Cook R. G., Rich R. R. Class II MHC molecules are specific receptors for staphylococcus enterotoxin A. Science. 1989 May 19;244(4906):817–820. doi: 10.1126/science.2658055. [DOI] [PubMed] [Google Scholar]
  34. O'Hehir R. E., Lamb J. R. Induction of specific clonal anergy in human T lymphocytes by Staphylococcus aureus enterotoxins. Proc Natl Acad Sci U S A. 1990 Nov;87(22):8884–8888. doi: 10.1073/pnas.87.22.8884. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Otten G. R., Germain R. N. Split anergy in a CD8+ T cell: receptor-dependent cytolysis in the absence of interleukin-2 production. Science. 1991 Mar 8;251(4998):1228–1231. doi: 10.1126/science.1900952. [DOI] [PubMed] [Google Scholar]
  36. Pietra B. A., De Inocencio J., Giannini E. H., Hirsch R. TCR V beta family repertoire and T cell activation markers in Kawasaki disease. J Immunol. 1994 Aug 15;153(4):1881–1888. [PubMed] [Google Scholar]
  37. Posnett D. N., Schmelkin I., Burton D. A., August A., McGrath H., Mayer L. F. T cell antigen receptor V gene usage. Increases in V beta 8+ T cells in Crohn's disease. J Clin Invest. 1990 Jun;85(6):1770–1776. doi: 10.1172/JCI114634. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Pullen A. M., Choi Y., Kushnir E., Kappler J., Marrack P. The open reading frames in the 3' long terminal repeats of several mouse mammary tumor virus integrants encode V beta 3-specific superantigens. J Exp Med. 1992 Jan 1;175(1):41–47. doi: 10.1084/jem.175.1.41. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. Rellahan B. L., Jones L. A., Kruisbeek A. M., Fry A. M., Matis L. A. In vivo induction of anergy in peripheral V beta 8+ T cells by staphylococcal enterotoxin B. J Exp Med. 1990 Oct 1;172(4):1091–1100. doi: 10.1084/jem.172.4.1091. [DOI] [PMC free article] [PubMed] [Google Scholar]
  40. Scheuber P. H., Denzlinger C., Wilker D., Beck G., Keppler D., Hammer D. K. Staphylococcal enterotoxin B as a nonimmunological mast cell stimulus in primates: the role of endogenous cysteinyl leukotrienes. Int Arch Allergy Appl Immunol. 1987;82(3-4):289–291. doi: 10.1159/000234209. [DOI] [PubMed] [Google Scholar]
  41. Soos J. M., Johnson H. M. Multiple binding sites on the superantigen, staphylococcal enterotoxin B, imparts versatility in binding to MHC class II molecules. Biochem Biophys Res Commun. 1994 Jun 15;201(2):596–602. doi: 10.1006/bbrc.1994.1743. [DOI] [PubMed] [Google Scholar]
  42. Takimoto H., Yoshikai Y., Kishihara K., Matsuzaki G., Kuga H., Otani T., Nomoto K. Stimulation of all T cells bearing V beta 1, V beta 3, V beta 11 and V beta 12 by staphylococcal enterotoxin A. Eur J Immunol. 1990 Mar;20(3):617–621. doi: 10.1002/eji.1830200323. [DOI] [PubMed] [Google Scholar]
  43. White J., Herman A., Pullen A. M., Kubo R., Kappler J. W., Marrack P. The V beta-specific superantigen staphylococcal enterotoxin B: stimulation of mature T cells and clonal deletion in neonatal mice. Cell. 1989 Jan 13;56(1):27–35. doi: 10.1016/0092-8674(89)90980-x. [DOI] [PubMed] [Google Scholar]

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