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Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1994 Aug;97(2):248–253. doi: 10.1111/j.1365-2249.1994.tb06076.x

Cytokine regulation of low-affinity IgE receptor (CD23) on monocytes from asthmatic subjects.

A Vecchiarelli 1, A Siracusa 1, C Monari 1, D Pietrella 1, C Retini 1, C Severini 1
PMCID: PMC1534681  PMID: 8050173

Abstract

The regulation of CD23 expression (Fc epsilon RII) by cytokines on monocytes from normal subjects, asymptomatic and acute asthmatics was investigated. CD23 was weakly expressed on cells from controls, but was significantly enhanced in the two groups of asthmatics. The addition of IL-4 on monocytes induced an increase of CD23 expression in cells from controls and asthmatics. Interferon-gamma (IFN-gamma) did not modulate CD23 expression in asthmatics or control subjects, while high doses of IL-6 (2000 U/ml) enhanced CD23 expression on cells from asthmatics or controls. In vitro stimulation of monocytes with Timothy grass pollen allergen did not enhance CD23 receptor in asthmatics with a positive skin test to this pollen. We speculate that CD23 expression in asthmatics is markedly enhanced by Th2-dependent cytokines, such as IL-4 and IL-6. Thus, the regulation of Th2 cell activation by anti-cytokine therapy could have an important effect on the down-regulation of CD23 on monocytes, and in shifting a Th2 subpopulation into a Th1 subpopulation by blocking Th2-dependent cytokines.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alderson M. R., Tough T. W., Ziegler S. F., Armitage R. J. Regulation of human monocyte cell-surface and soluble CD23 (Fc epsilon RII) by granulocyte-macrophage colony-stimulating factor and IL-3. J Immunol. 1992 Aug 15;149(4):1252–1257. [PubMed] [Google Scholar]
  2. Barnes P. J. A new approach to the treatment of asthma. N Engl J Med. 1989 Nov 30;321(22):1517–1527. doi: 10.1056/NEJM198911303212206. [DOI] [PubMed] [Google Scholar]
  3. Beutler B., Cerami A. Cachectin and tumour necrosis factor as two sides of the same biological coin. Nature. 1986 Apr 17;320(6063):584–588. doi: 10.1038/320584a0. [DOI] [PubMed] [Google Scholar]
  4. Borish L., Mascali J. J., Rosenwasser L. J. IgE-dependent cytokine production by human peripheral blood mononuclear phagocytes. J Immunol. 1991 Jan 1;146(1):63–67. [PubMed] [Google Scholar]
  5. Bottomly K. A functional dichotomy in CD4+ T lymphocytes. Immunol Today. 1988 Sep;9(9):268–274. doi: 10.1016/0167-5699(88)91308-4. [DOI] [PubMed] [Google Scholar]
  6. Coffman R. L., Ohara J., Bond M. W., Carty J., Zlotnik A., Paul W. E. B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells. J Immunol. 1986 Jun 15;136(12):4538–4541. [PubMed] [Google Scholar]
  7. Corominas M., Mestre M., Bas J., Verdaguer J., Valls A., Romeu A., Buendia E. CD23 expression on B-lymphocytes and its modulation by cytokines in allergic patients. Clin Exp Allergy. 1993 Jul;23(7):612–617. doi: 10.1111/j.1365-2222.1993.tb00902.x. [DOI] [PubMed] [Google Scholar]
  8. Delespesse G., Sarfati M., Peleman R. Influence of recombinant IL-4, IFN-alpha, and IFN-gamma on the production of human IgE-binding factor (soluble CD23). J Immunol. 1989 Jan 1;142(1):134–138. [PubMed] [Google Scholar]
  9. Fargeas C., Wu C. Y., Luo H. Y., Sarfati M., Delespesse G., Wu J. P. 1,25(OH)2 vitamin D3 inhibits the CD23 gene expression by human peripheral blood monocytes. J Immunol. 1990 Dec 15;145(12):4053–4058. [PubMed] [Google Scholar]
  10. Gordon J., Cairns J. A., Millsum M. J., Gillis S., Guy G. R. Interleukin 4 and soluble CD23 as progression factors for human B lymphocytes: analysis of their interactions with agonists of the phosphoinositide "dual pathway" of signalling. Eur J Immunol. 1988 Oct;18(10):1561–1565. doi: 10.1002/eji.1830181014. [DOI] [PubMed] [Google Scholar]
  11. Ikuta K., Takami M., Kim C. W., Honjo T., Miyoshi T., Tagaya Y., Kawabe T., Yodoi J. Human lymphocyte Fc receptor for IgE: sequence homology of its cloned cDNA with animal lectins. Proc Natl Acad Sci U S A. 1987 Feb;84(3):819–823. doi: 10.1073/pnas.84.3.819. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Joseph M., Auriault C., Capron A., Vorng H., Viens P. A new function for platelets: IgE-dependent killing of schistosomes. Nature. 1983 Jun 30;303(5920):810–812. doi: 10.1038/303810a0. [DOI] [PubMed] [Google Scholar]
  13. Kelly W. J., Hudson I., Phelan P. D., Pain M. C., Olinsky A. Atopy in subjects with asthma followed to the age of 28 years. J Allergy Clin Immunol. 1990 Mar;85(3):548–557. doi: 10.1016/0091-6749(90)90092-i. [DOI] [PubMed] [Google Scholar]
  14. Kikutani H., Inui S., Sato R., Barsumian E. L., Owaki H., Yamasaki K., Kaisho T., Uchibayashi N., Hardy R. R., Hirano T. Molecular structure of human lymphocyte receptor for immunoglobulin E. Cell. 1986 Dec 5;47(5):657–665. doi: 10.1016/0092-8674(86)90508-8. [DOI] [PubMed] [Google Scholar]
  15. Lüdin C., Hofstetter H., Sarfati M., Levy C. A., Suter U., Alaimo D., Kilchherr E., Frost H., Delespesse G. Cloning and expression of the cDNA coding for a human lymphocyte IgE receptor. EMBO J. 1987 Jan;6(1):109–114. doi: 10.1002/j.1460-2075.1987.tb04726.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. May L. T., Viguet H., Kenney J. S., Ida N., Allison A. C., Sehgal P. B. High levels of "complexed" interleukin-6 in human blood. J Biol Chem. 1992 Sep 25;267(27):19698–19704. [PubMed] [Google Scholar]
  17. Melewicz F. M., Kline L. E., Cohen A. B., Spiegelberg H. L. Characterization of Fc receptors for IgE on human alveolar macrophages. Clin Exp Immunol. 1982 Aug;49(2):364–370. [PMC free article] [PubMed] [Google Scholar]
  18. Melewicz F. M., Spiegelberg H. L. Fc receptors for IgE on a subpopulation of human peripheral blood monocytes. J Immunol. 1980 Sep;125(3):1026–1031. [PubMed] [Google Scholar]
  19. Mossalayi M. D., Lecron J. C., Dalloul A. H., Sarfati M., Bertho J. M., Hofstetter H., Delespesse G., Debre P. Soluble CD23 (Fc epsilon RII) and interleukin 1 synergistically induce early human thymocyte maturation. J Exp Med. 1990 Mar 1;171(3):959–964. doi: 10.1084/jem.171.3.959. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Old L. J. Tumor necrosis factor (TNF). Science. 1985 Nov 8;230(4726):630–632. doi: 10.1126/science.2413547. [DOI] [PubMed] [Google Scholar]
  21. Rankin J. A., Hitchcock M., Merrill W., Bach M. K., Brashler J. R., Askenase P. W. IgE-dependent release of leukotriene C4 from alveolar macrophages. Nature. 1982 May 27;297(5864):329–331. doi: 10.1038/297329a0. [DOI] [PubMed] [Google Scholar]
  22. Robinson D. S., Hamid Q., Ying S., Tsicopoulos A., Barkans J., Bentley A. M., Corrigan C., Durham S. R., Kay A. B. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med. 1992 Jan 30;326(5):298–304. doi: 10.1056/NEJM199201303260504. [DOI] [PubMed] [Google Scholar]
  23. Rouzer C. A., Scott W. A., Hamill A. L., Liu F. T., Katz D. H., Cohn Z. A. Secretion of leukotriene C and other arachidonic acid metabolites by macrophages challenged with immunoglobulin E immune complexes. J Exp Med. 1982 Oct 1;156(4):1077–1086. doi: 10.1084/jem.156.4.1077. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Sarfati M., Delespesse G. Possible role of human lymphocyte receptor for IgE (CD23) or its soluble fragments in the in vitro synthesis of human IgE. J Immunol. 1988 Oct 1;141(7):2195–2199. [PubMed] [Google Scholar]
  25. Saxon A., Ke Z., Bahati L., Stevens R. H. Soluble CD23 containing B cell supernatants induce IgE from peripheral blood B-lymphocytes and costimulate with interleukin-4 in induction of IgE. J Allergy Clin Immunol. 1990 Sep;86(3 Pt 1):333–344. doi: 10.1016/s0091-6749(05)80096-x. [DOI] [PubMed] [Google Scholar]
  26. Seder R. A., Boulay J. L., Finkelman F., Barbier S., Ben-Sasson S. Z., Le Gros G., Paul W. E. CD8+ T cells can be primed in vitro to produce IL-4. J Immunol. 1992 Mar 15;148(6):1652–1656. [PubMed] [Google Scholar]
  27. Siracusa A., Vecchiarelli A., Brugnami G., Marabini A., Felicioni D., Severini C. Changes in interleukin-1 and tumor necrosis factor production by peripheral blood monocytes after specific bronchoprovocation test in occupational asthma. Am Rev Respir Dis. 1992 Aug;146(2):408–412. doi: 10.1164/ajrccm/146.2.408. [DOI] [PubMed] [Google Scholar]
  28. Spiegelberg H. L. Structure and function of Fc receptors for IgE on lymphocytes, monocytes, and macrophages. Adv Immunol. 1984;35:61–88. doi: 10.1016/s0065-2776(08)60574-x. [DOI] [PubMed] [Google Scholar]
  29. Vecchiarelli A., Siracusa A., Cenci E., Puliti M., Abbritti G. Effect of corticosteroid treatment on interleukin-1 and tumour necrosis factor secretion by monocytes from subjects with asthma. Clin Exp Allergy. 1992 Mar;22(3):365–370. doi: 10.1111/j.1365-2222.1992.tb03097.x. [DOI] [PubMed] [Google Scholar]
  30. Vercelli D., Jabara H. H., Lee B. W., Woodland N., Geha R. S., Leung D. Y. Human recombinant interleukin 4 induces Fc epsilon R2/CD23 on normal human monocytes. J Exp Med. 1988 Apr 1;167(4):1406–1416. doi: 10.1084/jem.167.4.1406. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Walker C., Virchow J. C., Jr, Bruijnzeel P. L., Blaser K. T cell subsets and their soluble products regulate eosinophilia in allergic and nonallergic asthma. J Immunol. 1991 Mar 15;146(6):1829–1835. [PubMed] [Google Scholar]
  32. Willheim M., Gessl A., Berger R., Schedle A., Luger T., Föster O., Boltz-Nitulescu G. IL-6 augments Fc IgE receptor (Fc epsilon RII/CD23) expression on human monoblastic/monocytic cell lines U937, THP-1, and Mono-Mac-6 but not on blood monocytes. Regulatory effects of IL-4 and IFN-gamma. J Immunol. 1991 Sep 15;147(6):1837–1842. [PubMed] [Google Scholar]
  33. Yokota A., Kikutani H., Tanaka T., Sato R., Barsumian E. L., Suemura M., Kishimoto T. Two species of human Fc epsilon receptor II (Fc epsilon RII/CD23): tissue-specific and IL-4-specific regulation of gene expression. Cell. 1988 Nov 18;55(4):611–618. doi: 10.1016/0092-8674(88)90219-x. [DOI] [PubMed] [Google Scholar]
  34. Yukawa K., Kikutani H., Owaki H., Yamasaki K., Yokota A., Nakamura H., Barsumian E. L., Hardy R. R., Suemura M., Kishimoto T. A B cell-specific differentiation antigen, CD23, is a receptor for IgE (Fc epsilon R) on lymphocytes. J Immunol. 1987 Apr 15;138(8):2576–2580. [PubMed] [Google Scholar]
  35. te Velde A. A., Rousset F., Peronne C., De Vries J. E., Figdor C. G. IFN-alpha and IFN-gamma have different regulatory effects on IL-4-induced membrane expression of Fc epsilon RIIb and release of soluble Fc epsilon RIIb by human monocytes. J Immunol. 1990 Apr 15;144(8):3052–3059. [PubMed] [Google Scholar]

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