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. 1983 Apr;52(1):85–88.

IgE synthesis in vitro induced by T cell factors from patients with elevated serum IgE levels.

S Romagnani, E Maggi, G F Del Prete, M Ricci
PMCID: PMC1535572  PMID: 6602674

Abstract

The effect of unstimulated T cell culture supernatants (TCS) from patients with atopic dermatitis and high serum IgE levels on the IgE production in vitro by B cell rich suspensions from normal individuals or grass pollen sensitive patients with mild atopy was evaluated. TCS from patients with raised IgE enabled B cell suspensions from normal individuals to produce detectable amounts of IgE and potentiated the spontaneous IgE synthesis in vitro by B cell suspensions from grass sensitive patients. In contrast, the addition of TCS from normal subjects with low serum IgE levels did not increase or even reduced IgE synthesis by B cell cultures. When the same B cell cultures were analysed for their ability to produce IgG or IgM protein, no significant differences were observed. These findings indicate that T lymphocytes from patients with high serum IgE levels can release soluble factor(s) possessing isotype (IgE) specific potentiating activity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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