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. 1983 Sep;53(3):619–622.

Parietal cell antibodies in relation to basal serum gastrin in a normal population.

M Bins, P I Burgers, T Schuyt-Van Etten, S Selbach, T B van Wettum, L G Poels, C B Lamers, J H van Tongeren
PMCID: PMC1535647  PMID: 6616958

Abstract

Parietal cell antibodies, basal gastric pH and serum gastrin were determined in 544 normal non-achlorhydric subjects. Serum gastrin was significantly higher in subjects with parietal cell antibodies, both in the group with a weakly positive and in that with a strongly positive fluorescence score. The elevated serum gastrin level in subjects with circulating parietal cell antibodies was independent of gastric pH. It is suggested that parietal cell antibodies may interfere with gastrin receptors on the membrane of the parietal cell, thus influencing the feedback mechanism between the secretion of acid and gastrin, and resulting in an increase of the basal serum gastrin level at an unchanged basal gastric pH.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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