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. 1983 Sep;53(3):645–650.

Cellular immunity to the hepatitis B virion in acute hepatitis type B.

G Fattovich, A Alberti, C Crivellaro, P Pontisso, F Noventa, G Realdi
PMCID: PMC1535662  PMID: 6616959

Abstract

Ten patients were studied serially during acute hepatitis type B for lymphocyte sensitization to the hepatitis B surface antigen (HBsAg) and to the complete hepatitis B virion (Dane particle). Using the lymphocyte transformation test, sensitization to purified HBsAg was not observed during the first 10 days of illness but became detectable later, being particularly evident during convalescence, while sensitization to antigens of the complete virion, other than HBsAg, was demonstrable as soon as at the onset of symptoms, often at the time of maximum liver cell damage. These results indicate that in the course of acute hepatitis type B, lymphocyte sensitization to other antigens of the complete virion precedes that to HBsAg and may be of greater pathogenetic importance.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alberti A., Diana S., Sculard G. H., Eddleston A. L., Williams R. Detection of a new antibody system reacting with Dane particles in hepatitis B virus infection. Br Med J. 1978 Oct 14;2(6144):1056–1058. doi: 10.1136/bmj.2.6144.1056. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Alberti A., Pontisso P., Realdi G. Changes in hepatitis B virus DNA-polymerase activity in patients with chronic infection. J Med Virol. 1981;8(4):223–229. doi: 10.1002/jmv.1890080402. [DOI] [PubMed] [Google Scholar]
  3. Alberti A., Realdi G., Tremolada F., Spina G. P. Liver cell surface localization of hepatitis B antigen and of immunoglobulins in acute and chronic hepatitis and in liver cirrhosis. Clin Exp Immunol. 1976 Sep;25(3):396–402. [PMC free article] [PubMed] [Google Scholar]
  4. Chisari F. V., Bieber M. S., Josepho C. A., Xavier C., Anderson D. S. Functional properties of lymphocyte subpopulations in hepatitis B virus infection. II. Cytotoxic effector cell killing of targets that naturally express hepatitis B surface antigen and liver-specific lipoprotein. J Immunol. 1981 Jan;126(1):45–49. [PubMed] [Google Scholar]
  5. Desaules M., Frei P. C., Libanska J., Wuilleret B. Lack of leukocyte migration inhibition by hepatitis B antigen and normal nonspecific immunoreactivity in asymptomatic carriers. J Infect Dis. 1976 Nov;134(5):505–509. doi: 10.1093/infdis/134.5.505. [DOI] [PubMed] [Google Scholar]
  6. Dienstag J. L., Bhan A. K. Enhanced in vitro cell-mediated cytotoxicity in chronic hepatitis B virus infection: absence of specificity for virus-expressed antigen on target cell membranes. J Immunol. 1980 Nov;125(5):2269–2276. [PubMed] [Google Scholar]
  7. Dudley F. J., Fox R. A., Sherlock S. Cellular immunity and hepatitis-associated, Australia antigen liver disease. Lancet. 1972 Apr 1;1(7753):723–726. doi: 10.1016/s0140-6736(72)90234-6. [DOI] [PubMed] [Google Scholar]
  8. Dudley F. J., Giustino V., Sherlock S. Cell-mediated immunity in patients positive for hepatitis-associated antigen. Br Med J. 1972 Dec 30;4(5843):754–756. doi: 10.1136/bmj.4.5843.754. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Erard P. Technical study of the leucocyte migration inhibition test in agarose. Application to PPD and to hepatitis B antigen. Clin Exp Immunol. 1974 Nov;18(3):439–448. [PMC free article] [PubMed] [Google Scholar]
  10. Hoofnagle J. H., Dusheiko G. M., Seeff L. B., Jones E. A., Waggoner J. G., Bales Z. B. Seroconversion from hepatitis B e antigen to antibody in chronic type B hepatitis. Ann Intern Med. 1981 Jun;94(6):744–748. doi: 10.7326/0003-4819-94-6-744. [DOI] [PubMed] [Google Scholar]
  11. Ibrahim A. B., Vyas G. N., Perkins H. A. Immune response to hepatitis B surface antigen. Infect Immun. 1975 Jan;11(1):137–141. doi: 10.1128/iai.11.1.137-141.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Laiwah A. A. Lymphocyte transformation by Australia antigen. Lancet. 1971 Aug 28;2(7722):470–471. doi: 10.1016/s0140-6736(71)92633-x. [DOI] [PubMed] [Google Scholar]
  13. Lee W. M., Reed W. D., Osman C. G., Vahrman J., Zuckerman A. J., Eddleston A. L., Williams R. Immune responses to the hepatitis B surface antigen and liver-specific lipoprotein in acute type B hepatitis. Gut. 1977 Mar;18(3):250–257. doi: 10.1136/gut.18.3.250. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Mondelli M., Vergani G. M., Alberti A., Vergani D., Portmann B., Eddleston A. L., Williams R. Specificity of T lymphocyte cytotoxicity to autologous hepatocytes in chronic hepatitis B virus infection: evidence that T cells are directed against HBV core antigen expressed on hepatocytes. J Immunol. 1982 Dec;129(6):2773–2778. [PubMed] [Google Scholar]
  15. Neurath A. R., Strick N., Huang C. Y. Confirmatory evidence for the association of hepatitis B surface antigen with antigenic determinants reactive with antibodies present in some anti-HBe-positive sera. J Gen Virol. 1980 May;48(1):53–61. doi: 10.1099/0022-1317-48-1-53. [DOI] [PubMed] [Google Scholar]
  16. Neurath A. R., Trepo C., Chen M., Prince A. M. Identification of additional antigenic sites on Dane particles and the tubular forms of hepatitis B surface antigen. J Gen Virol. 1976 Mar;30(3):277–285. doi: 10.1099/0022-1317-30-3-277. [DOI] [PubMed] [Google Scholar]
  17. Realdi G., Alberti A., Rugge M., Bortolotti F., Rigoli A. M., Tremolada F., Ruol A. Seroconversion from hepatitis B e antigen to anti-HBe in chronic hepatitis B virus infection. Gastroenterology. 1980 Aug;79(2):195–199. [PubMed] [Google Scholar]
  18. Reed W. D., Mitchell C. G., Eddleston A. L., Lee W. M., Williams R., Zuckerman A. J. Exposure and immunity to hepatitis-B virus in a liver unit. Lancet. 1974 Apr 6;1(7858):581–583. doi: 10.1016/s0140-6736(74)92646-4. [DOI] [PubMed] [Google Scholar]
  19. Robinson W. S., Greenman R. L. DNA polymerase in the core of the human hepatitis B virus candidate. J Virol. 1974 Jun;13(6):1231–1236. doi: 10.1128/jvi.13.6.1231-1236.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Trevisan A., Realdi G., Alberti A., Ongaro G., Pornaro E., Meliconi R. Core antigen-specific immunoglobulin G bound to the liver cell membrane in chronic hepatitis B. Gastroenterology. 1982 Feb;82(2):218–222. [PubMed] [Google Scholar]
  21. de Gast G. C., Houwen B., Nieweg H. O. Specific lymphocyte stimulation by purified, heat-inactivated hepatitis-B antigen. Br Med J. 1973 Dec 22;4(5894):707–709. doi: 10.1136/bmj.4.5894.707. [DOI] [PMC free article] [PubMed] [Google Scholar]

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