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. 1991 Jul;85(1):61–65. doi: 10.1111/j.1365-2249.1991.tb05682.x

Detection of circulating Fc epsilon R2/CD23+ monocytes in patients with rheumatic diseases.

H Becker 1, P Potyka 1, C Weber 1, K Federlin 1
PMCID: PMC1535706  PMID: 1829991

Abstract

Recently, in vitro studies have demonstrated that expression of Fc epsilon R2/CD23 on normal monocytes can be specifically induced by IL-4. In order to investigate the interaction of IL-4 and monocytes in rheumatic diseases, flow cytometry studies were performed. Elevated numbers of circulating Fc epsilon R2/CD23+ monocytes were detected in patients with progressive systemic sclerosis (PSS) as compared with controls. In addition, supernatants derived from phytohaemagglutinin-stimulated peripheral blood mononuclear cells of PSS patients contained high activity to induce Fc epsilon R2/CD23 on CD14+ monocytes. An increased frequency of Fc epsilon R2/CD23+ monocytes was also observed in rheumatoid arthritis, and sequential studies in patients with systemic lupus erythematosus showed a close relationship between Fc epsilon R2/CD23+ monocytes and disease activity. It is suggested that IL-4 has an important role in the pathogenesis of PSS by activating monocytes, and might also contribute to monocyte activation in other rheumatic diseases.

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Selected References

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  1. Alcocer-Varela J., Laffon A., Alarcón-Segovia D. Defective monocyte production of, and T lymphocyte response to, interleukin-1 in the peripheral blood of patients with systemic lupus erythematosus. Clin Exp Immunol. 1984 Jan;55(1):125–132. [PMC free article] [PubMed] [Google Scholar]
  2. Alcocer-Varela J., Martinez-Cordero E., Alarcon-Segovia D. Spontaneous production of, and defective response to, interleukin-1 by peripheral blood mononuclear cells from patients with scleroderma. Clin Exp Immunol. 1985 Mar;59(3):666–672. [PMC free article] [PubMed] [Google Scholar]
  3. Arnett F. C., Edworthy S. M., Bloch D. A., McShane D. J., Fries J. F., Cooper N. S., Healey L. A., Kaplan S. R., Liang M. H., Luthra H. S. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988 Mar;31(3):315–324. doi: 10.1002/art.1780310302. [DOI] [PubMed] [Google Scholar]
  4. Becker H., Schauer U., Helmke K. B lymphocyte activation by insoluble anti-mu antibodies in patients with systemic lupus erythematosus. Clin Exp Immunol. 1986 Nov;66(2):365–372. [PMC free article] [PubMed] [Google Scholar]
  5. Becker H., Weber C., Storch S., Federlin K. Relationship between CD5+ B lymphocytes and the activity of systemic autoimmunity. Clin Immunol Immunopathol. 1990 Aug;56(2):219–225. doi: 10.1016/0090-1229(90)90143-e. [DOI] [PubMed] [Google Scholar]
  6. Crawford R. M., Finbloom D. S., Ohara J., Paul W. E., Meltzer M. S. B cell stimulatory factor-1 (interleukin 4) activates macrophages for increased tumoricidal activity and expression of Ia antigens. J Immunol. 1987 Jul 1;139(1):135–141. [PubMed] [Google Scholar]
  7. Decker J. L., Malone D. G., Haraoui B., Wahl S. M., Schrieber L., Klippel J. H., Steinberg A. D., Wilder R. L. NIH conference. Rheumatoid arthritis: evolving concepts of pathogenesis and treatment. Ann Intern Med. 1984 Dec;101(6):810–824. doi: 10.7326/0003-4819-101-6-810. [DOI] [PubMed] [Google Scholar]
  8. Defrance T., Vanbervliet B., Aubry J. P., Takebe Y., Arai N., Miyajima A., Yokota T., Lee F., Arai K., de Vries J. E. B cell growth-promoting activity of recombinant human interleukin 4. J Immunol. 1987 Aug 15;139(4):1135–1141. [PubMed] [Google Scholar]
  9. Delespesse G., Sarfati M., Heusser C. IgE synthesis. Curr Opin Immunol. 1989;2(4):506–512. doi: 10.1016/0952-7915(90)90003-y. [DOI] [PubMed] [Google Scholar]
  10. Delespesse G., Sarfati M., Rubio-Trujillo M., Wolowiec T. IgE receptors on human lymphocytes. II. Detection of cells bearing IgE receptors in unstimulated mononuclear cells by means of a monoclonal antibody. Eur J Immunol. 1986 Jul;16(7):815–821. doi: 10.1002/eji.1830160716. [DOI] [PubMed] [Google Scholar]
  11. Essner R., Rhoades K., McBride W. H., Morton D. L., Economou J. S. IL-4 down-regulates IL-1 and TNF gene expression in human monocytes. J Immunol. 1989 Jun 1;142(11):3857–3861. [PubMed] [Google Scholar]
  12. Famularo G., Procopio A., Giacomelli R., Danese C., Sacchetti S., Perego M. A., Santoni A., Tonietti G. Soluble interleukin-2 receptor, interleukin-2 and interleukin-4 in sera and supernatants from patients with progressive systemic sclerosis. Clin Exp Immunol. 1990 Sep;81(3):368–372. doi: 10.1111/j.1365-2249.1990.tb05340.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Fleischmajer R., Perlish J. S., West W. P. Ultrastructure of cutaneous cellular infiltrates in scleroderma. Arch Dermatol. 1977 Dec;113(12):1661–1666. [PubMed] [Google Scholar]
  14. Furukawa S., Matsubara T., Motohashi T., Nakachi S., Sasai K., Yabuta K. Expression of Fc epsilon R2/CD23 on peripheral blood macrophages/monocytes in Kawasaki disease. Clin Immunol Immunopathol. 1990 Aug;56(2):280–286. doi: 10.1016/0090-1229(90)90149-k. [DOI] [PubMed] [Google Scholar]
  15. Gordon J., Flores-Romo L., Cairns J. A., Millsum M. J., Lane P. J., Johnson G. D., MacLennan I. C. CD23: a multi-functional receptor/lymphokine? Immunol Today. 1989 May;10(5):153–157. doi: 10.1016/0167-5699(89)90171-0. [DOI] [PubMed] [Google Scholar]
  16. Janossy G., Panayi G., Duke O., Bofill M., Poulter L. W., Goldstein G. Rheumatoid arthritis: a disease of T-lymphocyte/macrophage immunoregulation. Lancet. 1981 Oct 17;2(8251):839–842. doi: 10.1016/s0140-6736(81)91107-7. [DOI] [PubMed] [Google Scholar]
  17. Kahaleh M. B., LeRoy E. C. Interleukin-2 in scleroderma: correlation of serum level with extent of skin involvement and disease duration. Ann Intern Med. 1989 Mar 15;110(6):446–450. doi: 10.7326/0003-4819-110-6-446. [DOI] [PubMed] [Google Scholar]
  18. Kumagai S., Ishida H., Iwai K., Tsubata T., Umehara H., Ozaki S., Suginoshita T., Araya S., Imura H. Possible different mechanisms of B cell activation in systemic lupus erythematosus and rheumatoid arthritis: opposite expression of low-affinity receptors for IgE (CD23) on their peripheral B cells. Clin Exp Immunol. 1989 Dec;78(3):348–353. [PMC free article] [PubMed] [Google Scholar]
  19. Leung D. Y., Schneeberger E. E., Siraganian R. P., Geha R. S., Bhan A. K. The presence of IgE on macrophages and dendritic cells infiltrating into the skin lesion of atopic dermatitis. Clin Immunol Immunopathol. 1987 Mar;42(3):328–337. doi: 10.1016/0090-1229(87)90021-3. [DOI] [PubMed] [Google Scholar]
  20. Monroe J. G., Haldar S., Prystowsky M. B., Lammie P. Lymphokine regulation of inflammatory processes: interleukin-4 stimulates fibroblast proliferation. Clin Immunol Immunopathol. 1988 Nov;49(2):292–298. doi: 10.1016/0090-1229(88)90119-5. [DOI] [PubMed] [Google Scholar]
  21. Preliminary criteria for the classification of systemic sclerosis (scleroderma). Subcommittee for scleroderma criteria of the American Rheumatism Association Diagnostic and Therapeutic Criteria Committee. Arthritis Rheum. 1980 May;23(5):581–590. doi: 10.1002/art.1780230510. [DOI] [PubMed] [Google Scholar]
  22. Shields J. G., Armitage R. J., Jamieson B. N., Beverley P. C., Callard R. E. Increased expression of surface IgM but not IgD or IgG on human B cells in response to IL-4. Immunology. 1989 Feb;66(2):224–227. [PMC free article] [PubMed] [Google Scholar]
  23. Shore A., Jaglal S., Keystone E. C. Enhanced interleukin 1 generation by monocytes in vitro is temporally linked to an early event in the onset or exacerbation of rheumatoid arthritis. Clin Exp Immunol. 1986 Aug;65(2):293–302. [PMC free article] [PubMed] [Google Scholar]
  24. Spiegelberg H. L. Structure and function of Fc receptors for IgE on lymphocytes, monocytes, and macrophages. Adv Immunol. 1984;35:61–88. doi: 10.1016/s0065-2776(08)60574-x. [DOI] [PubMed] [Google Scholar]
  25. Talal N., Flescher E. Rheumatoid arthritis: an editorial perspective based on cytokine imbalance. J Autoimmun. 1988 Aug;1(4):309–317. doi: 10.1016/0896-8411(88)90001-7. [DOI] [PubMed] [Google Scholar]
  26. Tan E. M., Cohen A. S., Fries J. F., Masi A. T., McShane D. J., Rothfield N. F., Schaller J. G., Talal N., Winchester R. J. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982 Nov;25(11):1271–1277. doi: 10.1002/art.1780251101. [DOI] [PubMed] [Google Scholar]
  27. Umehara H., Kumagai S., Ishida H., Suginoshita T., Maeda M., Imura H. Enhanced production of interleukin-2 in patients with progressive systemic sclerosis. Hyperactivity of CD4-positive T cells? Arthritis Rheum. 1988 Mar;31(3):401–407. doi: 10.1002/art.1780310312. [DOI] [PubMed] [Google Scholar]
  28. Vercelli D., Jabara H. H., Lee B. W., Woodland N., Geha R. S., Leung D. Y. Human recombinant interleukin 4 induces Fc epsilon R2/CD23 on normal human monocytes. J Exp Med. 1988 Apr 1;167(4):1406–1416. doi: 10.1084/jem.167.4.1406. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. Westermann J., Pabst R. Lymphocyte subsets in the blood: a diagnostic window on the lymphoid system? Immunol Today. 1990 Nov;11(11):406–410. doi: 10.1016/0167-5699(90)90160-b. [DOI] [PubMed] [Google Scholar]
  30. Yukawa K., Kikutani H., Owaki H., Yamasaki K., Yokota A., Nakamura H., Barsumian E. L., Hardy R. R., Suemura M., Kishimoto T. A B cell-specific differentiation antigen, CD23, is a receptor for IgE (Fc epsilon R) on lymphocytes. J Immunol. 1987 Apr 15;138(8):2576–2580. [PubMed] [Google Scholar]
  31. Zubler R. H., Huang Y. P., Miescher P. A. Mechanisms of physiologic B cell responses and B cell hyperactivity in systemic lupus erythematosus. Springer Semin Immunopathol. 1986;9(2-3):195–218. doi: 10.1007/BF02099022. [DOI] [PubMed] [Google Scholar]

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