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Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1983 May;52(2):266–270.

Immunoglobulins and other serological parameters in Chagas' disease: evidence for increased IgA levels in the chronic digestive form.

J A Sá Ferreira, B Galvão-Castro, W Macedo, C Castro
PMCID: PMC1535837  PMID: 6407792

Abstract

Immunoglobulin levels were measured in serum samples from 36 patients with different clinical forms of chronic Chagas' disease. Increased IgA levels were observed in 50% of the patients in the chronic digestive group and there was a significant correlation with the severity of the disease. IgG and IgM levels were within the normal range. Anti-ssDNA antibodies and EVI (endothelium, vessels and interstitium) antibodies were found in some patients with different clinical forms of the disease.

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Selected References

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  1. Brener Z. Immunity to Trypanosoma cruzi. Adv Parasitol. 1980;18:247–292. doi: 10.1016/s0065-308x(08)60401-7. [DOI] [PubMed] [Google Scholar]
  2. Camargo M. E., Hoshino S., Siqueira G. R. Hemagglutination with preserved, sensitized cells, a practical test for routine serologic diagnosis of American trypanosomiasis. Rev Inst Med Trop Sao Paulo. 1973 Mar-Apr;15(2):81–85. [PubMed] [Google Scholar]
  3. Cossio P. M., Diez C., Szarfman A., Kreutzer E., Candiolo B., Arana R. M. Chagasic cardiopathy. Demonstration of a serum gamma globulin factor which reacts with endocardium and vascular structures. Circulation. 1974 Jan;49(1):13–21. doi: 10.1161/01.cir.49.1.13. [DOI] [PubMed] [Google Scholar]
  4. De Freitas G., Da Costa S. C., Pereira N. de M., Quintão L. G., De Souza J. G. Imunoglobulinas na fase crônica da doença de Chagas. Mem Inst Oswaldo Cruz. 1976;74(2):183–190. doi: 10.1590/s0074-02761976000200005. [DOI] [PubMed] [Google Scholar]
  5. Hoshino-Shimizu S., Camargo M. E., Nagasse T. K. A stable polysaccharide-hemagglutination reagent for the diagnosis of acute or recent Trypanosoma cruzi infections. Rev Inst Med Trop Sao Paulo. 1978 Jul-Aug;20(4):208–212. [PubMed] [Google Scholar]
  6. Lelchuk R., Dalmasso A. P., Inglesini C. L., Alvarez M., Cerisola J. A. Immunoglobulin studies in serum of patients with American trypanosomiasis (Chagas' disease). Clin Exp Immunol. 1970 Apr;6(4):547–555. [PMC free article] [PubMed] [Google Scholar]
  7. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  8. Marsden P. D., Seah S. K., Mott K. E., Prata A., Platt H. Immunoglobulins in Chagas' disease. J Trop Med Hyg. 1970 Jul;73(7):157–161. [PubMed] [Google Scholar]
  9. NUSSENZVEIG V., SONNTAG R. Xenodiagnóstico artificial; novo processo; primeiros resultados positivos. Rev Paul Med. 1952 Jan;40(1):41–43. [PubMed] [Google Scholar]
  10. Thomasi T. B., Jr Secretory immunoglobulins. N Engl J Med. 1972 Sep 7;287(10):500–506. doi: 10.1056/NEJM197209072871008. [DOI] [PubMed] [Google Scholar]
  11. Vattuone N. H., Szarfman A., Gonzalez Cappa S. M. Antibody response and immunoglobulin levels in humans with acute or chronic Trypanosoma cruzi infections (Chagas' disease). J Trop Med Hyg. 1973 Feb;76(2):45–47. [PubMed] [Google Scholar]
  12. Waldman R. H., Mach J. P., Stella M. M., Rowe D. S. Secretory IgA in human serum. J Immunol. 1970 Jul;105(1):43–47. [PubMed] [Google Scholar]
  13. Walker W. A., Isselbacher K. J. Uptake and transport of macromolecules by the intestine. Possible role in clinical disorders. Gastroenterology. 1974 Sep;67(3):531–550. [PubMed] [Google Scholar]
  14. de REZENDE J., LAUAR K. M., de OLIVEIRA A. [Clinical and radiological aspects of aperistalsis of the esophagus]. Rev Bras Gastroenterol. 1960 Sep-Dec;12:247–262. [PubMed] [Google Scholar]

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