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. 1983 Oct;54(1):110–116.

Anti-lymphocyte antibodies in lethal mouse malaria. II. Induction of an autoantibody specific suppressor T cell by non-lethal P. yoelii.

J B de Souza, J H Playfair
PMCID: PMC1536195  PMID: 6225580

Abstract

The anti-lymphocyte autoantibody response to irradiated lethal Plasmodium berghei malaria parasites in normal mice was significantly reduced when recipients were pre-treated with splenic T cells from mice recovered from a non-lethal Plasmodium yoelii infection. Suppression was specific for the autoantibody and did not affect the antibody response to the parasite. Experiments involving sequential P. yoelii-P. berghei infections in situ revealed that recovery from P. berghei was possible when the interval between the two infections was 14 days or more. This ability to recover from P. berghei correlated with a progressive reduction of anti-lymphocyte autoantibody suggesting a useful role for the suppressor cell. The possible link between suppressor cells and anti-lymphocyte autoantibodies in malaria is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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