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. 1981 Dec;46(3):633–639.

The role of TG lymphocytes in cell-mediated immunity in patients with periodontal disease.

L Ivanyi, B Topic, P M Lydyard
PMCID: PMC1536311  PMID: 6978223

Abstract

Blood mononuclear cell suspensions from patients with a severe form of periodontal disease failed to respond by in vitro stimulation to a sonicate from the oral bacterium, Veillonella alcalescens. The proliferative response could be restored by the depletion of TG cells by rosetting with IgG-coated ox erythrocytes and by reconstitution of the cell suspension with 10% plastic-adherent monocytes. Small but statistically significant restoration of the Veillonella response was also achieved by the addition of indomethacin or mefenamic acid to unfractionated cell cultures, indicating only a minor role of prostaglandin (PG) synthesis in the expression of suppressor cells. Since the in vitro response to an unrelated antigen PPD had been found unimpaired, the described TG-cell-mediated suppression of the Veillonella response is apparently antigen-specific.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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