Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1982 Jan;47(1):133–137.

Failure to detect brain reactivity of lymphocytotoxins in cerebral lupus.

B A Pussell, F Blyth, J A Charlesworth
PMCID: PMC1536348  PMID: 7094418

Abstract

Lymphocytotoxic activity (LCA) was examined in the sera of 29 patients with systemic lupus erythematosus (SLE), including eight with cerebral involvement. LCA was elevated in 80% of samples and was significantly higher in the group with cerebral disease (P less than 0.001). No correlations were observed between LCA and immune complexes or complement components. Sera from 10 patients (six with cerebral SLE) were absorbed with homogenates of normal human frontal cortex and liver using protein standards to control for dilutional effects. No serum sample showed selective depletion of LCA following incubation with brain homogenate. It is concluded that no single parameter, including brain absorption of LCA, is effective in monitoring disease activity in cerebral lupus.

Full text

PDF
135

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bluestein H. G. Heterogeneous neurocytotoxic antibodies in systemic lupus erythematosus. Clin Exp Immunol. 1979 Feb;35(2):210–217. [PMC free article] [PubMed] [Google Scholar]
  2. Bluestein H. G., Zvaifler N. J. Brain-reactive lymphocytotoxic antibodies in the serum of patients with systemic lupus erythematosus. J Clin Invest. 1976 Feb;57(2):509–516. doi: 10.1172/JCI108303. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bresnihan B., Oliver M., Grigor R., Hughes G. R. Brain reactivity of lymphocytotoxic antibodies in systemic lupus erythematosus with and without cerebral involvement. Clin Exp Immunol. 1977 Dec;30(3):333–337. [PMC free article] [PubMed] [Google Scholar]
  4. Bresnihan B., Oliver M., Williams B., Hughes G. R. An antineuronal antibody cross-reacting with erythrocytes and lymphocytes in systemic lupus erythematosus. Arthritis Rheum. 1979 Apr;22(4):313–320. doi: 10.1002/art.1780220401. [DOI] [PubMed] [Google Scholar]
  5. Charlesworth J. A., Quin J. W., Macdonald G. J., Lennane R. J., Boughton C. R. Complement, lymphocytotoxins and immune complexes in infectious mononucleosis: serial studies in uncomplicated cases. Clin Exp Immunol. 1978 Nov;34(2):241–247. [PMC free article] [PubMed] [Google Scholar]
  6. Cohen A. S., Canoso J. J. Criteria for the classification of systemic lupus erythematosus--status 1972. Arthritis Rheum. 1972 Sep-Oct;15(5):540–543. doi: 10.1002/art.1780150512. [DOI] [PubMed] [Google Scholar]
  7. Mittal K. K., Rossen R. D., Sharp J. T., Lidsky M. D., Butler W. T. Lymphocyte cytotoxic antibodies in systemic lupus erythematosus. Nature. 1970 Mar 28;225(5239):1255–1256. doi: 10.1038/2251255a0. [DOI] [PubMed] [Google Scholar]
  8. Pinching A. J., Travers R. L., Hughes G. R., Jones T., Moss S. Oxygen-15 brain scanning for detection of cerebral involvement in systemic lupus erythematosus. Lancet. 1978 Apr 29;1(8070):898–900. doi: 10.1016/s0140-6736(78)90680-3. [DOI] [PubMed] [Google Scholar]
  9. Quin J. W., Charlesworth J. A., Bowman C., Macdonald G. J. Studies of lymphocytotoxins in infectious mononucleosis and systemic lupus erythematosus: evidence for immune complex-mediated cytotoxicity. Clin Exp Immunol. 1980 Mar;39(3):593–598. [PMC free article] [PubMed] [Google Scholar]
  10. TERASAKI P. I., MCCLELLAND J. D. MICRODROPLET ASSAY OF HUMAN SERUM CYTOTOXINS. Nature. 1964 Dec 5;204:998–1000. doi: 10.1038/204998b0. [DOI] [PubMed] [Google Scholar]
  11. Terasaki P. I., Mottironi V. D., Barnett E. V. Cytotoxins in disease. Autocytotoxins in lupus. N Engl J Med. 1970 Oct 1;283(14):724–728. doi: 10.1056/NEJM197010012831403. [DOI] [PubMed] [Google Scholar]
  12. Winchester R. J., Winfield J. B., Siegal F., Wernet P., Bentwich Z., Kunkel H. G. Analyses of lymphocytes from patients with rheumatoid arthritis and systemic lupus erythematosus. Occurrence of interfering cold-reactive antilymphocyte antibodies. J Clin Invest. 1974 Nov;54(5):1082–1092. doi: 10.1172/JCI107852. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Winfield J. B., Brunner C. M., Koffler D. Serologic studies in patients with systemic lupus erythematosus and central nervous system dysfunction. Arthritis Rheum. 1978 Apr;21(3):289–294. doi: 10.1002/art.1780210301. [DOI] [PubMed] [Google Scholar]
  14. Zubler R. H., Lange G., Lambert P. H., Miescher P. A. Detection of immune complexes in unheated sera by modified 125I-Clq binding test. Effect of heating on the binding of Clq by immune complexes and application of the test to systemic lupus erythematosus. J Immunol. 1976 Jan;116(1):232–235. [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES