Abstract
The aim of this study was to investigate whether dendritic reticulum cells (DRC) in normal lymphoid tissue and in malignant non-Hodgkin's lymphomas possess receptors for the third complement component (C3 receptors). For this purpose we studied the in situ expression of C3 receptors in lymphoid tissue by staining frozen tissue sections with an antiserum specific for human C3 receptors (AC3RS), using a modified immunoperoxidase method. The results indicate that DRC of normal and malignant lymphoid tissue express large amounts of C3 receptors. Absorption experiments revealed that the C3 receptors of DRC are identical with, or at least share common antigenic sites with, the C3 receptors expressed by tonsil B cells.
Full text
PDFImages in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Gerdes J., Klatt U., Stein H. Xenoantiserum to human C3 receptors: its preparation and effect on the C3b and C3d receptors of tonsil cells and the C3b receptors of erythrocytes and neutrophils. Immunology. 1980 Jan;39(1):75–84. [PMC free article] [PubMed] [Google Scholar]
- Graham R. C., Jr, Karnovsky M. J. The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. J Histochem Cytochem. 1966 Apr;14(4):291–302. doi: 10.1177/14.4.291. [DOI] [PubMed] [Google Scholar]
- Groscurth P. Nicht-lymphatische Zellen in der Lymphknotenrinde der Maus. I. Morphologie und Verteilung der interdigitierenden Zellen und der dendritischen Retikulumzellen im mesenterialen Lymphknoten der adulten ICR Maus. Pathol Res Pract. 1980 Nov;169(3-4):212–234. doi: 10.1016/s0344-0338(80)80002-1. [DOI] [PubMed] [Google Scholar]
- Klaus G. G., Humphrey J. H. The generation of memory cells. I. The role of C3 in the generation of B memory cells. Immunology. 1977 Jul;33(1):31–40. [PMC free article] [PubMed] [Google Scholar]
- Nossal G. J., Abbot A., Mitchell J., Lummus Z. Antigens in immunity. XV. Ultrastructural features of antigen capture in primary and secondary lymphoid follicles. J Exp Med. 1968 Feb 1;127(2):277–290. doi: 10.1084/jem.127.2.277. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Nussenzweig M. C., Steinman R. M. Contribution of dendritic cells to stimulation of the murine syngeneic mixed leukocyte reaction. J Exp Med. 1980 May 1;151(5):1196–1212. doi: 10.1084/jem.151.5.1196. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Papadimitriou C. S., Stein H., Lennert K. The complexity of immunohistochemical staining pattern of Hodgkin and Sternberg-reed cells--demonstration of immunoglobulin, albumin, alpha1-antichymotrypsin and lysozyme. Int J Cancer. 1978 May 15;21(5):531–541. doi: 10.1002/ijc.2910210502. [DOI] [PubMed] [Google Scholar]
- Papamichail M., Gutierrez C., Embling P., Johnson P., Holborow E. J., Pepys M. B. Complement dependence of localisation of aggregated IgG in germinal centres. Scand J Immunol. 1975;4(4):343–347. doi: 10.1111/j.1365-3083.1975.tb02635.x. [DOI] [PubMed] [Google Scholar]
- Stein H., Bonk A., Tolksdorf G., Lennert K., Rodt H., Gerdes J. Immunohistologic analysis of the organization of normal lymphoid tissue and non-Hodgkin's lymphomas. J Histochem Cytochem. 1980 Aug;28(8):746–760. doi: 10.1177/28.8.7003001. [DOI] [PubMed] [Google Scholar]
- Steinman R. M., Cohn Z. A. Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution. J Exp Med. 1973 May 1;137(5):1142–1162. doi: 10.1084/jem.137.5.1142. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tsan M. F., McIntyre P. A. Stimulation by propylthiouracil of the hexose monophosphate shunt in human polymorphonuclear leucocytes during phagocytosis. Br J Haematol. 1975 Oct;31(2):193–208. doi: 10.1111/j.1365-2141.1975.tb00850.x. [DOI] [PubMed] [Google Scholar]
- White R. G., Henderson D. C., Eslami M. B., Neilsen K. H. Localization of a protein antigen in the chicken spleen. Effect of various manipulative procedures on the morphogenesis of the germinal centre. Immunology. 1975 Jan;28(1):1–21. [PMC free article] [PubMed] [Google Scholar]