Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1982 Feb;47(2):253–259.

Role of antibody in the protection of mice from arthritis induced by Mycoplasma pulmonis.

E C Keystone, A J Cunningham, A Metcalfe, M Kennedy, P A Quinn
PMCID: PMC1536526  PMID: 7075023

Abstract

C3H and C57Bl10 mice exhibit a differential susceptibility to arthritis induced by Mycoplasma pulmonis. Resistant C57Bl10 mice consistently demonstrated higher complement-fixing antibody titres than susceptible C3H mice throughout the development of the acute arthritis. A strong correlation was demonstrated between the levels of anti-mycoplasma antibody and resistance to acute arthritis in six strains of mice. To test the hypothesis that the difference of arthritis resistance of C3H and C57Bl10 mice was caused by a different susceptibility of their lymphocytes to mitogenic stimulation by M. pulmonis, we investigated the generation of non-specific immunoglobulin in vivo and in vitro. M. pulmonis acted as a polyclonal mitogen, but stimulated approximately equal responses in lymphocytes of both strains.

Full text

PDF
259

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barden J. A., Tully J. G. Experimental arthritis in mice with Mycoplasma pulmonis. J Bacteriol. 1969 Oct;100(1):5–10. doi: 10.1128/jb.100.1.5-10.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Biberfeld G., Gronowicz E. Mycoplasma pneumoniae is a polyclonal B-cell activator. Nature. 1976 May 20;261(5557):238–239. doi: 10.1038/261238a0. [DOI] [PubMed] [Google Scholar]
  3. Cole B. C., Golightly-Rowland L., Ward J. R. Arthritis of mice induced by Mycoplasma pulmonis: humoral antibody and lymphocyte responses of CBA mice. Infect Immun. 1975 Nov;12(5):1083–1092. doi: 10.1128/iai.12.5.1083-1092.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Cunningham A. J., Szenberg A. Further improvements in the plaque technique for detecting single antibody-forming cells. Immunology. 1968 Apr;14(4):599–600. [PMC free article] [PubMed] [Google Scholar]
  5. Hannan P. C. Observations on the arthritogenic properties of Sabin's type C murine mycoplasma (Mycoplasma histotropicum). J Gen Microbiol. 1971 Aug;67(3):363–365. doi: 10.1099/00221287-67-3-363. [DOI] [PubMed] [Google Scholar]
  6. Harwick H. J., Mahoney A. D., Kalmanson G. M., Guze L. B. Arthritis in mice due to infection with Mycoplasma pulmonis. II. Serological and histological features. J Infect Dis. 1976 Feb;133(2):103–112. doi: 10.1093/infdis/133.2.103. [DOI] [PubMed] [Google Scholar]
  7. Keystone E., Taylor-Robinson D., Pope C., Taylor G., Furr P. Effect of inherited deficiency of the fifth component of complement on arthritis induced in mice by Mycoplasma pulmonis. Arthritis Rheum. 1978 Sep-Oct;21(7):792–797. doi: 10.1002/art.1780210709. [DOI] [PubMed] [Google Scholar]
  8. Molinaro G. A., Dray S. Antibody coated erythrocytes as a manifold probe for antigens. Nature. 1974 Apr 5;248(448):515–517. doi: 10.1038/248515a0. [DOI] [PubMed] [Google Scholar]
  9. Naot Y., Ginsburg H. Activation of B lymphocytes by mycoplasma mitogen(s). Immunology. 1978 Apr;34(4):715–720. [PMC free article] [PubMed] [Google Scholar]
  10. Naot Y., Siman-Tov R., Ginsburg H. Mitogenic activity of Mycoplasma pulmonis. II. Studies on the biochemical nature of the mitogenic factor. Eur J Immunol. 1979 Feb;9(2):149–154. doi: 10.1002/eji.1830090211. [DOI] [PubMed] [Google Scholar]
  11. Rittenberg M. B., Pratt K. L. Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen. Proc Soc Exp Biol Med. 1969 Nov;132(2):575–581. doi: 10.3181/00379727-132-34264. [DOI] [PubMed] [Google Scholar]
  12. Taylor G., Taylor-Robinson D. Factors in resistance to and recovery from M. pulmonis-induced arthritis in mice. Ann Rheum Dis. 1977 Jun;36(3):232–238. doi: 10.1136/ard.36.3.232. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Taylor G., Taylor-Robinson D., Slavin G. Effect of immunosuppression on arthritis in mice induced by Mycoplasma pulmonis. Ann Rheum Dis. 1974 Jul;33(4):376–384. doi: 10.1136/ard.33.4.376. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES