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. 1983 Mar;51(3):439–447.

The distribution and possible significance of cells identified in human lymphoid tissue by the monoclonal antibody HNK-1.

A W Ritchie, K James, H S Micklem
PMCID: PMC1536772  PMID: 6221840

Abstract

The monoclonal antibody HNK-1 identifies a subpopulation of lymphocytes containing almost all of the natural killer (NK) and antibody-dependent killer (K) cell activity. Using an immunoperoxidase technique on frozen tissue sections of human spleen, tonsil and lymph node we have demonstrated that cells identified by this antibody are almost exclusively confined to germinal centres. Comparison with the distribution of B cells, T cells and T cell subsets underlines the distinctive distribution of these cells for which a physiological role in the maturation of antibody affinity during immune responses is suggested.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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