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. 1982 Oct;50(1):163–170.

Insulin antibodies induced by bovine insulin therapy.

W G Reeves, U Kelly
PMCID: PMC1536847  PMID: 6756728

Abstract

Insulin antibodies are detectable in the sera of most patients within 3-4 months of starting treatment with conventional bovine insulins. Various factors determine the immunogenicity of insulin preparations including the genetic background of the recipient. This causes wide variation in response. Solid phase absorption studies as well as competitive binding in fluid phase indicate that the antibodies formed are almost always specific for determinants shared by the endogenous human molecule. This has important implications for the metabolic effect of insulin antibodies in vivo as well as for mechanisms of autoantibody production in man.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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