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. 1982 Oct;50(1):83–91.

High titres of anti-T antibodies and other haemagglutinins in human malaria.

M Zouali, P Druilhe, M Gentilini, A Eyquem
PMCID: PMC1536851  PMID: 7172512

Abstract

The prevalence of antibodies against (i) human red blood cells (RBC) of A and B groups, (ii) trypsinized O Rh+ RBC and (iii) neuraminidase treated O Rh+ RBC were investigated both in sera of Africans from a malaria endemic area of Upper Volta and in sera of Europeans with acute malaria from a Paris hospital. An increased frequency of high titres of haemagglutinins was observed against A and B as well as O Rh+ trypsinized human RBC, thus confirming previously published results. In addition, agglutination of neuraminidase treated RBC showed that the titres were increased in about 40% of Africans studied and in about 80% of patients with acute malaria. Using agglutination with a specific anti-T lectin and inhibition with two ligands, it was found that sera of malarious patients contain high titres of antibodies directed against the T antigen of neuraminidase treated RBC. The mechanisms of appearance of high titres of autohaemagglutinins in malaria and their possible interference in the anaemia associated with this disease are discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adeniyi-Jones C. Agglutination of tanned sheep erythrocytes by serum from Nigerian adults and children. Lancet. 1967 Jan 28;1(7483):188–190. doi: 10.1016/s0140-6736(67)91826-0. [DOI] [PubMed] [Google Scholar]
  2. Adner M. M., Altstatt L. B., Conrad M. E. Coombs'-positive hemolytic disease in malaria. Ann Intern Med. 1968 Jan;68(1):33–38. doi: 10.7326/0003-4819-68-1-33. [DOI] [PubMed] [Google Scholar]
  3. BIRD G. W. ANTI-T IN PEANUTS. Vox Sang. 1964 Nov-Dec;9:748–749. doi: 10.1111/j.1423-0410.1964.tb04072.x. [DOI] [PubMed] [Google Scholar]
  4. EYQUEM A., FAUCON N. Etude de l'isohémagglutinine anti-T au cours des maladies du sang et des organes hématopoiétiques; étude chez 230 malades. Ann Inst Pasteur (Paris) 1953 Mar;84(3):662–663. [PubMed] [Google Scholar]
  5. Facer C. A., Bray R. S., Brown J. Direct Coombs antiglobulin reactions in Gambian children with Plasmodium falciparum malaria. I. Incidence and class specificity. Clin Exp Immunol. 1979 Jan;35(1):119–127. [PMC free article] [PubMed] [Google Scholar]
  6. Greenwood B. M. Heterophile antibodies in Nigerian sera. Clin Exp Immunol. 1970 Feb;6(2):197–206. [PMC free article] [PubMed] [Google Scholar]
  7. Greenwood B. M., Vick R. M. Evidence for a malaria mitogen in human malaria. Nature. 1975 Oct 16;257(5527):592–594. doi: 10.1038/257592a0. [DOI] [PubMed] [Google Scholar]
  8. Harboe M. Cold auto-agglutinins. Vox Sang. 1971 Apr;20(4):289–305. doi: 10.1111/j.1423-0410.1971.tb00447.x. [DOI] [PubMed] [Google Scholar]
  9. Howard R. J. Alterations in the surface membrane of red blood cells during malaria. Immunol Rev. 1982;61:67–107. doi: 10.1111/j.1600-065x.1982.tb00374.x. [DOI] [PubMed] [Google Scholar]
  10. Howard R. J., Day K. P. Plasmodium berghei: modification of sialic acid on red cells from infected mouse blood. Exp Parasitol. 1981 Feb;51(1):95–103. doi: 10.1016/0014-4894(81)90046-1. [DOI] [PubMed] [Google Scholar]
  11. Jerusalem C. Immunopathology of malaria. Isr J Med Sci. 1978 Jun;14(6):620–650. [PubMed] [Google Scholar]
  12. Kano K., McGregor I. A., Milgrom F. Hemagglutinins in sera of Africans of Gambia. Proc Soc Exp Biol Med. 1968 Dec;129(3):849–853. doi: 10.3181/00379727-129-33440. [DOI] [PubMed] [Google Scholar]
  13. Lotan R., Skutelsky E., Danon D., Sharon N. The purification, composition, and specificity of the anti-T lectin from peanut (Arachis hypogaea). J Biol Chem. 1975 Nov 10;250(21):8518–8523. [PubMed] [Google Scholar]
  14. McBride J. S., Micklem H. S., Ure J. M. Immunosuppression in murine malaria. I. Response to type III pneumococcal polysaccharide. Immunology. 1977 May;32(5):635–644. [PMC free article] [PubMed] [Google Scholar]
  15. Osler A. G., Mulligan J. J., Jr, Rodriguez E. Weight estimates of rabbit anti-human serum albumin based on antigen-binding and precipitin analyses: specific hemagglutinating activities of 7 S and 19 S components. J Immunol. 1966 Feb;96(2):334–344. [PubMed] [Google Scholar]
  16. Pereira M. E., Kabat E. A., Lotan R., Sharon N. Immunochemical studies on the specificity of the peanut (Arachis hypogaea) agglutinin. Carbohydr Res. 1976 Oct;51(1):107–118. doi: 10.1016/s0008-6215(00)84040-9. [DOI] [PubMed] [Google Scholar]
  17. Ree G. H. Complement and malaria. Ann Trop Med Parasitol. 1976 Jun;70(2):247–248. doi: 10.1080/00034983.1976.11687118. [DOI] [PubMed] [Google Scholar]
  18. Rosenberg Y. J. Autoimmune and polyclonal B cell responses during murine malaria. Nature. 1978 Jul 13;274(5667):170–172. doi: 10.1038/274170a0. [DOI] [PubMed] [Google Scholar]
  19. Sedlacek H. H., Seiler F. R., Schwick H. G. Neuraminidase and tumor immunotherapy. Klin Wochenschr. 1977 Mar 1;55(5):199–214. doi: 10.1007/BF01487712. [DOI] [PubMed] [Google Scholar]
  20. Sherman I. W., Jones L. A. Plasmodium lophurae: membrane proteins of erythrocyte-free plasmodia and malaria-infected red cells. J Protozool. 1979 Aug;26(3):489–501. doi: 10.1111/j.1550-7408.1979.tb04659.x. [DOI] [PubMed] [Google Scholar]
  21. Springer G. F., Desai P. R., Banatwala I. Blood group MN specific substances and precursors in normal and malignant human breast tissues. Naturwissenschaften. 1974 Oct;61(10):457–458. doi: 10.1007/BF00597216. [DOI] [PubMed] [Google Scholar]
  22. Springer G. F., Desai P. R. Cross-reacting carcinoma-associated antigens with blood group and precursor specificities. Transplant Proc. 1977 Mar;9(1):1105–1111. [PubMed] [Google Scholar]
  23. Uhlenbruck G., Pardoe G. I., Bird G. W. On the specificity of lectins with a broad agglutination spectrum. II. Studies on the nature of the T-antigen and the specific receptors for the lectin of Arachis hypogoea (ground-nut). Z Immunitatsforsch Allerg Klin Immunol. 1969 Nov;138(5):423–433. [PubMed] [Google Scholar]
  24. Vincent H. M., Wilson R. J. Reduced lectin binding on erythrocytes of monkeys infected with malaria. Trans R Soc Trop Med Hyg. 1980;74(4):449–451. doi: 10.1016/0035-9203(80)90051-6. [DOI] [PubMed] [Google Scholar]

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