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. 1980 May;40(2):373–382.

The effect of exogenous interferon: acceleration of autoimmune and renal diseases in (NZB/W) F1 mice.

C Adam, Y Thoua, P Ronco, P Verroust, M Tovey, L Morel-Maroger
PMCID: PMC1536985  PMID: 6160000

Abstract

To determine the effect of prolonged administration of exogenous interferon on the autoimmune disease of NZB/W female mice, forty-four NZB/W mice received three injections per week of 6.4 x 10(4) interferon units from birth to 33 weeks, forty mice were injected with mock interferon and forty-eight mice were left untreated. In mice injected with interferon growth was delayed, survival was decreased, and the severity of the glomerulonephritis was enhanced. Interferon increased the titre of serum anti-ssDNA and anti-soluble nucleoprotein antibodies, but had no effect on the circulating immune complex load. These results suggest that interferon in some way affects local deposition of immune complexes within the glomerulus.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adam C., Verroust P., Robitaille P., Pontillon F. A solid-phase radioimmunoassay for anti-SNP antibodies. J Immunol Methods. 1979;27(2):133–143. doi: 10.1016/0022-1759(79)90260-6. [DOI] [PubMed] [Google Scholar]
  2. Andrews B. S., Eisenberg R. A., Theofilopoulos A. N., Izui S., Wilson C. B., McConahey P. J., Murphy E. D., Roths J. B., Dixon F. J. Spontaneous murine lupus-like syndromes. Clinical and immunopathological manifestations in several strains. J Exp Med. 1978 Nov 1;148(5):1198–1215. doi: 10.1084/jem.148.5.1198. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Benveniste J., Henson P. M., Cochrane C. G. Leukocyte-dependent histamine release from rabbit platelets. The role of IgE, basophils, and a platelet-activating factor. J Exp Med. 1972 Dec 1;136(6):1356–1377. doi: 10.1084/jem.136.6.1356. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Billiau A., Sobis H., De Somer P. Influence of interferon on virus particle formation in different oncornavirus carrier cell lines. Int J Cancer. 1973 Nov 15;12(3):646–653. doi: 10.1002/ijc.2910120313. [DOI] [PubMed] [Google Scholar]
  5. Carpenter D. F., Steinberg A. D., Schur P. H., Talal N. The pathogenesis of autoimmunity in New Zealand mice. II. Acceleration of glomerulonephritis by polyinosinic-polycytidylic acid. Lab Invest. 1970 Dec;23(6):628–634. [PubMed] [Google Scholar]
  6. Datta S. K., Manny N., Andrzejewski C., André-Schwartz J., Schwartz R. S. Genetic studies of autoimmunity and retrovirus expression in crosses of New Zealand black mice I. Xenotropic virus. J Exp Med. 1978 Mar 1;147(3):854–871. doi: 10.1084/jem.147.3.854. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Datta S. K., McConahey P. J., Manny N., Theofilopoulos A. N., Dixon F. J., Schwartz R. S. Genetic studies of autoimmunity and retrovirus expression in crosses of New Zealand black mice. II. The viral envelope glycoprotein gp70. J Exp Med. 1978 Mar 1;147(3):872–881. doi: 10.1084/jem.147.3.872. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Friedman R. M., Chang E. H., Ramseur J. M., Myers M. W. Interferon-directed inhibition of chronic murine leukemia virus production in cell cultures: lack of effect on intracellular viral markers. J Virol. 1975 Sep;16(3):569–574. doi: 10.1128/jvi.16.3.569-574.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Gabriel R. 1-Methylisatin 3-thiosemicarbazone treatment of NZB x NZW hybrid mice. Br J Exp Pathol. 1971 Jun;52(3):271–275. [PMC free article] [PubMed] [Google Scholar]
  10. Gresser I., Maury C., Tovey M., Morel-Maroger L., Pontillon F. Progressive glomerulonephritis in mice treated with interferon preparations at birth. Nature. 1976 Sep 30;263(5576):420–422. doi: 10.1038/263420a0. [DOI] [PubMed] [Google Scholar]
  11. Gresser I. On the varied biologic effects of interferon. Cell Immunol. 1977 Dec;34(2):406–415. doi: 10.1016/0008-8749(77)90262-3. [DOI] [PubMed] [Google Scholar]
  12. Gresser J., Morel-Maroger L., Verroust P., Rivière Y., Guillon J. C. Anti-interferon globulin inhibits the development of glomerulonephritis in mice infected at birth with lymphocytic choriomeningitis virus. Proc Natl Acad Sci U S A. 1978 Jul;75(7):3413–3416. doi: 10.1073/pnas.75.7.3413. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Heremans H., Billiau A., Colombatti A., Hilgers J., de Somer P. Interferon treatment of NZB mice: accelerated progression of autoimmune disease. Infect Immun. 1978 Sep;21(3):925–930. doi: 10.1128/iai.21.3.925-930.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Imamura M., Mellors R. C., Strand M., August J. T. Murine Type C viral envelope glycoprotein gp69/71 and lupus-like glomerulonephritis of New Zealand mice. An immunoperoxidase study. Am J Pathol. 1977 Feb;86(2):375–386. [PMC free article] [PubMed] [Google Scholar]
  15. Izui S., McConahey P. J., Theofilopoulos A. N., Dixon F. J. Association of circulating retroviral gp70-anti-gp70 immune complexes with murine systemic lupus erythematosus. J Exp Med. 1979 May 1;149(5):1099–1116. doi: 10.1084/jem.149.5.1099. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Klassen L. W., Budman D. R., Williams G. W., Steinberg A. D., Gerber N. L. Ribavirin: efficacy in the treatment of murine autoimmune disease. Science. 1977 Feb 25;195(4280):787–789. doi: 10.1126/science.299957. [DOI] [PubMed] [Google Scholar]
  17. Klassen L. W., Williams G. W., Reinertsen J. L., Gerber N. L., Steinberg A. D. Ribavirin treatment in murine autoimmune disease. I. Therapeutic efficacy and effect on the immune response. Arthritis Rheum. 1979 Feb;22(2):145–154. doi: 10.1002/art.1780220207. [DOI] [PubMed] [Google Scholar]
  18. Lambert P. H., Dixon F. J. Genesis of antinuclear antibody in NZB-W mice: role of genetic factors and of viral infections. Clin Exp Immunol. 1970 Jun;6(6):829–839. [PMC free article] [PubMed] [Google Scholar]
  19. Lambert P. H., Dixon F. J. Pathogenesis of the glomerulonephritis of NZB/W mice. J Exp Med. 1968 Mar 1;127(3):507–522. doi: 10.1084/jem.127.3.507. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Mellors R. C., Shirai T., Aoki T., Huebner R. J., Krawczynski K. Wild-type Gross leukemia virus and the pathogenesis of the glomerulonephritis of New Zealand mice. J Exp Med. 1971 Jan 1;133(1):113–132. doi: 10.1084/jem.133.1.113. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Morel-Maroger L., Sloper J. C., Vinter J., Woodrow D., Gresser I. An ultrastructural study of the development of nephritis in mice treated with interferon in the neonatal period. Lab Invest. 1978 Nov;39(5):513–522. [PubMed] [Google Scholar]
  22. Steinberg A. D., Baron S., Talal N. The pathogenesis of autoimmunity in New Zealand mice, I. Induction of antinucleic acid antibodies by polyinosinic-polycytidylic acid. Proc Natl Acad Sci U S A. 1969 Aug;63(4):1102–1107. doi: 10.1073/pnas.63.4.1102. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Tan E. M. An immunologic precipitin system between soluble nucleoprotein and serum antibody in systemic lupus erythematosus. J Clin Invest. 1967 May;46(5):735–745. doi: 10.1172/JCI105574. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Theofilopoulos A. N., Wilson C. B., Dixon F. J. The Raji cell radioimmune assay for detecting immune complexes in human sera. J Clin Invest. 1976 Jan;57(1):169–182. doi: 10.1172/JCI108257. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Tovey M. G., Begon-Lours J., Gresser I. A method for the large scale production of potent interferon preparations. Proc Soc Exp Biol Med. 1974 Jul;146(3):809–815. doi: 10.3181/00379727-146-38196. [DOI] [PubMed] [Google Scholar]
  26. Walker S. E. Accelerated mortality in young NZB/NZW mice treated with the interferon inducer tilorone hydrochloride. Clin Immunol Immunopathol. 1977 Sep;8(2):204–212. doi: 10.1016/0090-1229(77)90110-6. [DOI] [PubMed] [Google Scholar]
  27. Walker S. E., Anver M. R. Stimulated autoantibody response and increased longevity in NZB/NZW mice treated with cyclophosphamide and tilorone. Clin Exp Immunol. 1978 Sep;33(3):453–462. [PMC free article] [PubMed] [Google Scholar]

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