Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1978 Sep;33(3):437–440.

Reduced immunoglobulin concentration and impaired macrophage function in mice due to diphenylhydantoin.

J Seager, H M Coovadia, J F Soothill
PMCID: PMC1537428  PMID: 737896

Abstract

Diphenylhydantoin (DPH) depresses serum IgA and IgM concentrations and polyvinyl pyrrolidone (PVP) clearance in mice.

Full text

PDF
440

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aarli J. A. Drug-induced IgA deficiency in epileptic patients. Arch Neurol. 1976 Apr;33(4):296–299. doi: 10.1001/archneur.1976.00500040080014. [DOI] [PubMed] [Google Scholar]
  2. Aarli J. A., Tönder O. Effect of antiepileptic drugs on serum and salivary IgA. Scand J Immunol. 1975;4(4):391–396. doi: 10.1111/j.1365-3083.1975.tb02641.x. [DOI] [PubMed] [Google Scholar]
  3. Clough J. D., Mims L. H., Strober W. Deficient IgA antibody responses to arsanilic acid bovine serum albumin (BSA) in neonatally thymectomized rabbits. J Immunol. 1971 Jun;106(6):1624–1629. [PubMed] [Google Scholar]
  4. FAHEY J. L., MCKELVEY E. M. QUANTITATIVE DETERMINATION OF SERUM IMMUNOGLOBULINS IN ANTIBODY-AGAR PLATES. J Immunol. 1965 Jan;94:84–90. [PubMed] [Google Scholar]
  5. Feldmann M. Cell interactions in the immune response in vitro. II. The requirement for macrophages in lymphoid cell collaboration. J Exp Med. 1972 May 1;135(5):1049–1058. doi: 10.1084/jem.135.5.1049. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Goudie J. H., Burnett D. A gas-chromatographic method for the simultaneous determination of phenobarbitone, primidone and phenytoin in serum using a nitrogen detector. Clin Chim Acta. 1973 Feb 12;43(3):423–429. doi: 10.1016/0009-8981(73)90482-8. [DOI] [PubMed] [Google Scholar]
  7. Levo Y., Markowitz O., Trainin N. Hydantoin immunosuppression and carcinogenesis. Clin Exp Immunol. 1975 Mar;19(3):521–527. [PMC free article] [PubMed] [Google Scholar]
  9. Pritchard H., Riddaway J., Micklem H. S. Immune responses in congenitally thymus-less mice. II. Quantitative studies of serum immunoglobulins, the antibody response to sheep erythrocytes, and the effect of thymus allografting. Clin Exp Immunol. 1973 Jan;13(1):125–138. [PMC free article] [PubMed] [Google Scholar]
  10. Proesmans W., Jaeken J., Eeckels R. D-penicillamine-induced IgA deficiency in Wilson's disease. Lancet. 1976 Oct 9;2(7989):804–805. doi: 10.1016/s0140-6736(76)90641-3. [DOI] [PubMed] [Google Scholar]
  11. Seager J., Jamison D. L., Wilson J., Hayward A. R., Soothill J. F. IgA deficiency, epilepsy, and phenytoin treatment. Lancet. 1975 Oct 4;2(7936):632–635. doi: 10.1016/s0140-6736(75)90115-4. [DOI] [PubMed] [Google Scholar]
  12. Sorrell T. C., Forbes I. J. Depression of immune competence by phenytoin and carbamazepine. Studies in vivo and in vitro. Clin Exp Immunol. 1975 May;20(2):273–285. [PMC free article] [PubMed] [Google Scholar]
  13. Spiegelberg H. L. Biological activities of immunoglobulins of different classes and subclasses. Adv Immunol. 1974;19(0):259–294. doi: 10.1016/s0065-2776(08)60254-0. [DOI] [PubMed] [Google Scholar]
  14. Stanworth D. R., Williamson J. P., Shadforth M., Felix-Davies D., Thompson R. Drug-induced IgA deficiency in rheumatoid arthritis. Lancet. 1977 May 7;1(8019):1001–1002. doi: 10.1016/s0140-6736(77)92297-8. [DOI] [PubMed] [Google Scholar]
  15. Torrigiani G. Quantitative estimation of antibody in the immunoglobulin classes of the mouse. II. Thymic dependence of the different classes. J Immunol. 1972 Jan;108(1):161–164. [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES