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. 1979 Jan;35(1):96–100.

Levels of the serum amyloid A protein (SAA) in normal persons of different age groups.

W Hijmans, J D Sipe
PMCID: PMC1537586  PMID: 428149

Abstract

Serum amyloid A (SAA) has been implicated by three independent studies to increase in concentration with ageing. The present study measured SAA concentration in 395 samples from 302 healthy individuals ranging in age from 21 to 100 years. The average SAA concentration was 20 microgram/ml, with only five serum samples falling below 5 microgram/ml. SAA concentrations are expressed in terms of cross-reactivity of purified, denatured SAA with anti-AA antibodies, rather than the purified, denatured amyloid fibril protein AA from tissues, which has been used in the past. No age-related increase in SAA concentration was observed in the present study. The average SAA concentration in these normal, healthy individuals was almost a hundred-fold less than values measured in acute phase human serum in a separate study with the same reagents.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Benditt E. P., Eriksen N. Amyloid protein SAA is associated with high density lipoprotein from human serum. Proc Natl Acad Sci U S A. 1977 Sep;74(9):4025–4028. doi: 10.1073/pnas.74.9.4025. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Benson M. D., Skinner M., Lian J., Cohen A. S. "A" protein of amyloidosis. Isolation of a cross-reacting component from serum by affinity chromatography. Arthritis Rheum. 1975 Jul-Aug;18(4):315–322. doi: 10.1002/art.1780180404. [DOI] [PubMed] [Google Scholar]
  3. Glenner G. G., Page D. L. Amyloid, amyloidosis, and amyloidogenesis. Int Rev Exp Pathol. 1976;15:1–92. [PubMed] [Google Scholar]
  4. Gorevic P. D., Rosenthal C. J., Franklin E. C. Amyloid-related serum component (SAA)--studies in acute infections, medullary thyroid carcinoma, and postsurgery. Clin Immunol Immunopathol. 1976 Jul;6(1):83–93. doi: 10.1016/0090-1229(76)90063-5. [DOI] [PubMed] [Google Scholar]
  5. Ignaczak T. F., Sipe J. D., Linke F. P., Glenner G. G. Immunochemical studies on the nature of the serum component (SAA) related to secondary amyloidosis. J Lab Clin Med. 1977 May;89(5):1092–1104. [PubMed] [Google Scholar]
  6. Isersky C., Page D. L., Cuatrecasas P., DeLellis R. A., Glenner G. G. Murine amyloidosis: immunologic characterization of amyloid fibril protein. J Immunol. 1971 Dec;107(6):1690–1698. [PubMed] [Google Scholar]
  7. Linder E., Anders R. F., Natvig J. B. Connective tissue origin of the amyloid-related protein SAA. J Exp Med. 1976 Nov 2;144(5):1336–1346. doi: 10.1084/jem.144.5.1336. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. McAdam K. P., Anders R. F., Smith S. R., Russell D. A., Price M. A. Association of amyloidosis with erythema nodosum leprosum reactions and recurrent neutrophil leucocytosis in leprosy. Lancet. 1975 Sep 27;2(7935):572–573. doi: 10.1016/s0140-6736(75)90168-3. [DOI] [PubMed] [Google Scholar]
  9. McAdam K. P., Elin R. J., Sipe J. D., Wolff S. M. Changes in human serum amyloid A and C-reactive protein after etiocholanolone-induced inflammation. J Clin Invest. 1978 Feb;61(2):390–394. doi: 10.1172/JCI108949. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Radl J., Sepers J. M., Skvaril F., Morell A., Hijmans W. Immunoglobulin patterns in humans over 95 years of age. Clin Exp Immunol. 1975 Oct;22(1):84–90. [PMC free article] [PubMed] [Google Scholar]
  11. Rosenthal C. J., Franklin E. C. Variation with age and disease of an amyloid A protein-related serum component. J Clin Invest. 1975 Apr;55(4):746–753. doi: 10.1172/JCI107985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Sipe J. D., McAdam K. P., Torain B. F., Glenner G. G. Conformational flexibility of the serum amyloid precursor SAA. Br J Exp Pathol. 1976 Oct;57(5):582–592. [PMC free article] [PubMed] [Google Scholar]
  13. Sipe J. D., McAdam K. P., Torain B. F., Pollock P. S. Isolation and structural properties of murine SAA--the acute phase serum precursor of amyloid AA. Immunol Commun. 1977;6(1):1–12. doi: 10.3109/08820137709055799. [DOI] [PubMed] [Google Scholar]
  14. Weinstein R. L., Kelch R. P., Jenner M. R., Kaplan S. L., Grumbach M. M. Secretion of unconjugated androgens and estrogens by the normal and abnormal human testis before and after human chorionic gonadotropin. J Clin Invest. 1974 Jan;53(1):1–6. doi: 10.1172/JCI107526. [DOI] [PMC free article] [PubMed] [Google Scholar]

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