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. 1979 Feb;35(2):227–235.

IgG synthesis within the brain in multiple sclerosis and subacute sclerosing panencephalitis.

P W Ewan, P J Lachmann
PMCID: PMC1537633  PMID: 436336

Abstract

Intracerebral IgG synthesis was measured in patients with multiple sclerosis (MS), subacute sclerosing panencephalitis (SSPE) and in two control groups--patients with other neurological disorders and patients with non-neurological diseases. Significantly increased synthesis was found at all times in SSPE (P less than 0.001). Significantly elevated values were also found in MS (P less than 0.001), but in this group increased values were found mainly during relapse. These findings emphasize the immunological component in SSPE where there is known to be persistent measles virus infection in the brain, and in MS where the aetiology is unknown. Intracerebral IgG synthesis appears to be of diagnostic value in MS. The cerebrospinal fluid (CSF) IgG/total protein ratio was also measured in MS, and correlated only moderately well with the calculated IgG synthesis, indicating that the ratio provides a cruder estimate of intracerebral IgG synthesis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ADAMS J. M., IMAGAWA D. T. Measles antibodies in multiple sclerosis. Proc Soc Exp Biol Med. 1962 Dec;111:562–566. doi: 10.3181/00379727-111-27855. [DOI] [PubMed] [Google Scholar]
  2. Abramsky O., Lisak R. P., Silberberg D. H., Pleasure D. E. Antibodies to oligodendroglia in patients with multiple sclerosis. N Engl J Med. 1977 Dec 1;297(22):1207–1211. doi: 10.1056/NEJM197712012972204. [DOI] [PubMed] [Google Scholar]
  3. Connolly J. H. Additional data on measles virus antibody and antigen in subacute sclerosing panencephalitis. Neurology. 1968 Jan;18(1 Pt 2):87–90. doi: 10.1212/wnl.18.1_part_2.087. [DOI] [PubMed] [Google Scholar]
  4. Connolly J. H., Allen I. V., Hurwitz L. J., Millar J. H. Measles-virus antibody and antigen in subacute sclerosing panencephalitis. Lancet. 1967 Mar 11;1(7489):542–544. doi: 10.1016/s0140-6736(67)92117-4. [DOI] [PubMed] [Google Scholar]
  5. Cutler R. W., Merler E., Hammerstad J. P. Production of antibody by the central nervous system in subacute sclerosing panencephalitis. Neurology. 1968 Jan;18(1 Pt 2):129–132. doi: 10.1212/wnl.18.1_part_2.129. [DOI] [PubMed] [Google Scholar]
  6. Cutler R. W., Page L., Galicich J., Watters G. V. Formation and absorption of cerebrospinal fluid in man. Brain. 1968;91(4):707–720. doi: 10.1093/brain/91.4.707. [DOI] [PubMed] [Google Scholar]
  7. Gutstein H. S., Cohen S. R. Spinal fluid differences in experimental allergic encephalomyelitis and multiple sclerosis. Science. 1978 Jan 20;199(4326):301–303. doi: 10.1126/science.619457. [DOI] [PubMed] [Google Scholar]
  8. Haire M., Fraser K. B., Millar J. H. Measles and other virus-specific immunoglobulins in multiple sclerosis. Br Med J. 1973 Sep 22;3(5881):612–615. doi: 10.1136/bmj.3.5881.612. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Laterre E. C., Callewaert A., Heremans J. F., Sfaello Z. Electrophoretic morphology of gamma globulins in cerebrospinal fluid of multiple sclerosis and other diseases of the nervous system. Neurology. 1970 Oct;20(10):982–990. doi: 10.1212/wnl.20.10.982. [DOI] [PubMed] [Google Scholar]
  10. Lennon V., Mackay I. R. Binding of 125 I myelin basic protein by serum and cerebrospinal fluid. Clin Exp Immunol. 1972 Aug;11(4):595–603. [PMC free article] [PubMed] [Google Scholar]
  11. Link H., Müller R. Immunoglobulins in multiple sclerosis and infections of the nervous system. Arch Neurol. 1971 Oct;25(4):326–344. doi: 10.1001/archneur.1971.00490040052007. [DOI] [PubMed] [Google Scholar]
  12. Lisak R. P., Heinze R. G., Falk G. A., Kies M. W. Search for anti-encephalitogen antibody in human demyelinative diseases. Neurology. 1968 Jan;18(1 Pt 2):122–128. doi: 10.1212/wnl.18.1_part_2.122. [DOI] [PubMed] [Google Scholar]
  13. Lumsden C. E. The immunogenesis of the multiple sclerosis plaque. Brain Res. 1971 May 21;28(3):365–390. doi: 10.1016/0006-8993(71)90052-7. [DOI] [PubMed] [Google Scholar]
  14. McDonald W. I., Halliday A. M. Diagnosis and classification of multiple sclerosis. Br Med Bull. 1977 Jan;33(1):4–9. [PubMed] [Google Scholar]
  15. Norrby E., Link H., Olsson J. E., Panelius M., Salmi A., Vandvik B. Comparison of antibodies against different viruses in cerebrospinal fluid and serum samples from patients with multiple sclerosis. Infect Immun. 1974 Oct;10(4):688–694. doi: 10.1128/iai.10.4.688-694.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Payne F. E., Baublis J. V., Itabashi H. H. Isolation of measles virus from cell cultures of brain from a patient with subacute sclerosing panencephalitis. N Engl J Med. 1969 Sep 11;281(11):585–589. doi: 10.1056/NEJM196909112811103. [DOI] [PubMed] [Google Scholar]
  17. Pertschuk L. P., Cook A. W., Gupta J. K., Broome J. D., Vuletin J. C., Kim D. S., Brigati D. J., Rainford E. A., Nidsgorski F. Jejunal immunopathology in amyotrophic lateral sclerosis and multiple sclerosis. Identification of viral antigens by immunofluorescence. Lancet. 1977 May 28;1(8022):1119–1125. doi: 10.1016/s0140-6736(77)92382-0. [DOI] [PubMed] [Google Scholar]
  18. Prasad I., Broome J. D., Pertschuk L. P., Gupta J., Cook A. W. Recovery of Paramyxovirus from the jejunum of patients with multiple sclerosis. Lancet. 1977 May 28;1(8022):1117–1119. doi: 10.1016/s0140-6736(77)92381-9. [DOI] [PubMed] [Google Scholar]
  19. Tanaka R., Iwasaki Y., Koprowski H. Intracisternal virus-like particles in brain of a multiple sclerosis patient. J Neurol Sci. 1976 May;28(1):121–126. doi: 10.1016/0022-510X(76)90053-8. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Tourtellotte W. W., Parker J. A., Herndon R. M., Cuadros C. V. Subacute sclerosing panencephalitis: brain immunoglobulin-G, measles antibody and albumin. Neurology. 1968 Jan;18(1 Pt 2):117–121. doi: 10.1212/wnl.18.1_part_2.117. [DOI] [PubMed] [Google Scholar]
  21. Tourtellotte W. On cerebrospinal fluid immunoglobulin-G (IgG) quotients in multiple sclerosis and other diseases. A review and a new formula to estimate the amount of IgG synthesized per day by the central nervous system. J Neurol Sci. 1970 Mar;10(3):279–304. doi: 10.1016/0022-510x(70)90156-5. [DOI] [PubMed] [Google Scholar]
  22. Vandvik B., Degré M. Measles virus antibodies in serum and cerebrospinal fluid in patients with multiple sclerosis and other neurological disorders, with special reference to measles antibody synthesis within the central nervous system. J Neurol Sci. 1975 Feb;24(2):201–219. doi: 10.1016/0022-510x(75)90233-6. [DOI] [PubMed] [Google Scholar]
  23. Vandvik B., Norrby E., Nordal H. J., Degré M. Oligoclonal measles virus-specific IgG antibodies isolated from cerebrospinal fluids, brain extracts, and sera from patients with subacute sclerosing panencephalitis and multiple sclerosis. Scand J Immunol. 1976;5(8):979–992. doi: 10.1111/j.1365-3083.1976.tb03050.x. [DOI] [PubMed] [Google Scholar]
  24. Vandvik B., Norrby E. Oligoclonal IgG antibody response in the central nervous system to different measles virus antigens in subacute sclerosing panencephalitis. Proc Natl Acad Sci U S A. 1973 Apr;70(4):1060–1063. doi: 10.1073/pnas.70.4.1060. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Woyciechowska J. L., Madden D. L., Sever J. L. Absence of measles-virus antigen in jejunum of multiple-sclerosis patients. Lancet. 1977 Nov 19;2(8047):1046–1049. doi: 10.1016/s0140-6736(77)91881-5. [DOI] [PubMed] [Google Scholar]

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