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. 1974 Oct;18(2):187–192.

Rosette formation by mouse lymphocytes. III. Receptors for immunoglobulin on normal and activated T cells

C Soteriades-Vlachos, Maria I C Gyöngyössy, J H L Playfair
PMCID: PMC1537899  PMID: 4549625

Abstract

By the use of an indirect immunofluorescent method for the identification of mouse T lymphocytes forming rosettes with antibody-coated erythrocytes, it was found that about 10% of the T cells in normal mouse spleen have receptors for antibody. Inhibition experiments with purified aggregated immunoglobulins showed that IgG2 is the major class involved. The same receptor was found on T cells activated against H-2 isoantigens. The importance of using the appropriate red cells and antiserum for demonstrating receptors on T cells is stressed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Basten A., Miller J. F., Sprent J., Pye J. A receptor for antibody on B lymphocytes. I. Method of detection and functional significance. J Exp Med. 1972 Mar 1;135(3):610–626. doi: 10.1084/jem.135.3.610. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Basten A., Warner N. L., Mandel T. A receptor for antibody on B lymphocytes. II. Immunochemical and electron microscopy characteristics. J Exp Med. 1972 Mar 1;135(3):627–642. doi: 10.1084/jem.135.3.627. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Davies A. J., Carter R. L., Leuchars E., Wallis V. The morphology of immune reactions in normal, thymectomized and reconstituted mice. II. The response to oxazolone. Immunology. 1969 Jul;17(1):111–126. [PMC free article] [PubMed] [Google Scholar]
  4. Eden A., Bianco C., Nussenzweig V., Mayer M. M. C3 split products inhibit the binding of antigen-antibody-complement complexes to B lymphocytes. J Immunol. 1973 May;110(5):1452–1453. [PubMed] [Google Scholar]
  5. Greenberg A. H., Shen L., Roitt I. M. Characterization of the antibody-dependent cytotoxic cell. A non-phagocytic monocyte? Clin Exp Immunol. 1973 Oct;15(2):251–259. [PMC free article] [PubMed] [Google Scholar]
  6. Gyöngyössy M. I., Playfair J. H. Indirect immunofluorescence of mouse thymus-derived cells using heterologous anti-brain serum. Cell Immunol. 1973 Apr;7(1):118–123. doi: 10.1016/0008-8749(73)90187-1. [DOI] [PubMed] [Google Scholar]
  7. Gyöngyössy M. I., Playfair J. H. Rosette formation by mouse lymphocytes. I. Demonstration by indirect immunofluorescence of T cells binding sheep erythrocytes. Clin Exp Immunol. 1974 Oct;18(2):169–176. [PMC free article] [PubMed] [Google Scholar]
  8. Hay F. C., Torrigiani G., Roitt I. M. The binding of human IgG subclasses to human monocytes. Eur J Immunol. 1972 Jun;2(3):257–261. doi: 10.1002/eji.1830020312. [DOI] [PubMed] [Google Scholar]
  9. Lay W. H., Nussenzweig V. Ca++-dependent binding of antigen-19 S antibody complexes to macrophages. J Immunol. 1969 May;102(5):1172–1178. [PubMed] [Google Scholar]
  10. Lee S. T., Paraskevas F. Cell surface-associated gamma globulins in lymphocytes. IV. Lack of detection of surface globulin on B-cells and acquisition of surface G globulin by T-cells during primary response. J Immunol. 1972 Dec;109(6):1262–1271. [PubMed] [Google Scholar]
  11. Liew F. Y. The detection and production of macrophage cytophilic antibody to different antigens in different laboratory animals. Immunology. 1971 Dec;21(6):1045–1058. [PMC free article] [PubMed] [Google Scholar]
  12. Marchalonis J. J., Cone R. E., Atwell J. L. Isolation and partial characterization of lymphocyte surface immunoglobulins. J Exp Med. 1972 Apr 1;135(4):956–971. doi: 10.1084/jem.135.4.956. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Raff M. C., Feldmann M., De Petris S. Monospecificity of bone marrow-derived lymphocytes. J Exp Med. 1973 Apr 1;137(4):1024–1030. doi: 10.1084/jem.137.4.1024. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Rhodes J. Receptor for monomeric IgM on guinea-pig splenic macrophages. Nature. 1973 Jun 29;243(5409):527–528. doi: 10.1038/243527a0. [DOI] [PubMed] [Google Scholar]
  15. Wilson A. B., Marchand R. M., Wilson D. V., Devey M., Coombs R. R. Reaginic antibodies on basophils in grass pollen allergy, as shown by rosette-formation. Int Arch Allergy Appl Immunol. 1972;42(5):668–680. doi: 10.1159/000230647. [DOI] [PubMed] [Google Scholar]
  16. Yoshida T. O., Andersson B. Evidence for a receptor recognizing antigen complexed immunoglobulin on the surface of activated mouse thymus lymphocytes. Scand J Immunol. 1972;1(4):401–408. doi: 10.1111/j.1365-3083.1972.tb03306.x. [DOI] [PubMed] [Google Scholar]

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