Abstract
The course of cutaneous infection with Leishmania mexicana was studied in normally nourished and protein deprived C57Bl/6 mice. Mice fed a normal diet showed self-resolving lesions and produced cellular and humoral responses against the parasite. In contrast, mice fed a protein deficient diet which developed chronic protein calorie deficiency failed to recover from L. mexicana infection. Non-healing protein deprived mice had depressed delayed hypersensitivity response (DHR) and in vitro lymphocyte reactivity to leishmanial antigen. Responses to PHA and Con A were also suppressed. The possible interaction between malnutrition, impairment of the immune response and chronicity of cutaneous leishmaniasis is discussed.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bell R. G., Hazell L. A., Price P. Influence of dietary protein restriction on immune competence. II. Effect on lymphoid tissue. Clin Exp Immunol. 1976 Nov;26(2):314–326. [PMC free article] [PubMed] [Google Scholar]
- Blanca I., Malavé I. Changes in the development of the 3LL tumor in syngeneic mice in relation to protein calorie malnutrition. Clin Immunol Immunopathol. 1978 Aug;10(4):389–397. doi: 10.1016/0090-1229(78)90150-2. [DOI] [PubMed] [Google Scholar]
- Bryceson A. D., Preston P. M., Bray R. S., Dumonde D. C. Experimental cutaneous leishmaniasis. II. Effects of immunosuppression and antigenic competition on the course of infection with Leishmania enriettii in the guinea-pig. Clin Exp Immunol. 1972 Feb;10(2):305–335. [PMC free article] [PubMed] [Google Scholar]
- Cooper W. C., Good R. A., Mariani T. Effects of protein insufficiency on immune responsiveness. Am J Clin Nutr. 1974 Jun;27(6):647–664. doi: 10.1093/ajcn/27.6.647. [DOI] [PubMed] [Google Scholar]
- Coovadia H. M., Soothill J. F. The effect of amino acid restricted diets on the clearance of 125I-labelled polyvinyl pyrrolidone in mice. Clin Exp Immunol. 1976 Mar;23(3):562–567. [PMC free article] [PubMed] [Google Scholar]
- Handman E., Spira D. T. Growth of Leishmania amastigotes in macrophages from normal and immune mice. Z Parasitenkd. 1977 Aug 25;53(1):75–81. doi: 10.1007/BF00383117. [DOI] [PubMed] [Google Scholar]
- Malavé I., Németh A., Blanca I. Immune response in malnutrition. Effect of protein deficiency on the DNA synthetic response to alloantigens. Int Arch Allergy Appl Immunol. 1978;56(2):128–135. doi: 10.1159/000232015. [DOI] [PubMed] [Google Scholar]
- Matossian-Rogers A., Lumsden W. H., Dumonde D. C. Numerical immunotaxonomy of Leishmania. I. Differentiation of four strains of Leishmania by serological tests. Immunology. 1976 Jul;31(1):1–19. [PMC free article] [PubMed] [Google Scholar]
- Mauel J., Behin R. Cell-mediated and humoral immunity to protozoan infections. Transplant Rev. 1974;19(0):121–146. doi: 10.1111/j.1600-065x.1974.tb00130.x. [DOI] [PubMed] [Google Scholar]
- Passwell J. H., Steward M. W., Soothill J. F. The effects of protein malnutrition on macrophage function and the amount and affinity of antibody response. Clin Exp Immunol. 1974 Jul;17(3):491–495. [PMC free article] [PubMed] [Google Scholar]
- Preston P. M., Carter R. L., Leuchars E., Davies A. J., Dumonde D. C. Experimental cutaneous leishmaniasis. 3. Effects of thymectomy on the course of infection of CBA mice with Leishmania tropica. Clin Exp Immunol. 1972 Feb;10(2):337–357. [PMC free article] [PubMed] [Google Scholar]
- Pérez H., Labrador F., Torrealba J. W. Variations in the response of five strains of mice to Leishmania mexicana. Int J Parasitol. 1979 Feb;9(1):27–32. doi: 10.1016/0020-7519(79)90062-6. [DOI] [PubMed] [Google Scholar]
- Zuckerman A. Current status of the immunology of blood and tissue Protozoa. I. Leishmania. Exp Parasitol. 1975 Dec;38(3):370–400. doi: 10.1016/0014-4894(75)90123-x. [DOI] [PubMed] [Google Scholar]