Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1980 Jan;39(1):44–52.

Intracerebral synthesis of antibodies to measles and distemper viruses in patients with subacute sclerosing panencephalitis and multiple sclerosis.

N T Gorman, J Habicht, P J Lachmann
PMCID: PMC1537929  PMID: 7389198

Abstract

Serum and cerebrospinal fluid (CSF) measles and distemper antibody levels were quantified in a series of twenty patients (four subacute sclerosing panencephalitis (SSPE); ten multiple sclerosis (MS); six non-MS neurological cases) using independent competitive inhibition radioimmunoassays. These results were used in a Tourtellotte calculation to measure the intracerebral IgG synthesis to each virus. The results confirmed that in SSPE there is a greatly enhanced intracerebral measles antibody synthesis (6.0 mg/day). However, it was found that in SSPE this represents only part of a general systemic measles hyperimmunization as the intracerebral measles antibody synthesis relative to the total body measles synthesis was not significantly different from other groups (8%); In MS patients there was increased intracerebral immunoglobulin synthesis but the measles antibody levels were neither significantly elevated nor different from the control group. No evidence was found to support the concept that canine distemper virus is implicated in either MS or SSPE.

Full text

PDF
47

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ADAMS J. M., IMAGAWA D. T. Measles antibodies in multiple sclerosis. Proc Soc Exp Biol Med. 1962 Dec;111:562–566. doi: 10.3181/00379727-111-27855. [DOI] [PubMed] [Google Scholar]
  2. Appel M. J. Pathogenesis of canine distemper. Am J Vet Res. 1969 Jul;30(7):1167–1182. [PubMed] [Google Scholar]
  3. Carp R. I., Licursi P. C., Merz P. A., Merz G. S. Decreased percentage of polymorphonuclear neutrophils in mouse peripheral blood after inoculation with material from multiple sclerosis patients. J Exp Med. 1972 Sep 1;136(3):618–629. doi: 10.1084/jem.136.3.618. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Connolly J. H., Allen I. V., Hurwitz L. J., Millar J. H. Measles-virus antibody and antigen in subacute sclerosing panencephalitis. Lancet. 1967 Mar 11;1(7489):542–544. doi: 10.1016/s0140-6736(67)92117-4. [DOI] [PubMed] [Google Scholar]
  5. Cook S. D., Dowling P. C. A possible association between house pets and multiple sclerosis. Lancet. 1977 May 7;1(8019):980–982. doi: 10.1016/s0140-6736(77)92281-4. [DOI] [PubMed] [Google Scholar]
  6. Cook S. D., Dowling P. C., Russell W. C. Multiple sclerosis and canine distemper. Lancet. 1978 Mar 18;1(8064):605–606. doi: 10.1016/s0140-6736(78)91047-4. [DOI] [PubMed] [Google Scholar]
  7. Ebina T., Tsukamoto T., Suzuki H., Takase S., Itahara K., Ishida N. Measles virus in jejunum of patients with multiple sclerosis. Lancet. 1979 Jan;1(8107):99–99. doi: 10.1016/s0140-6736(79)90082-5. [DOI] [PubMed] [Google Scholar]
  8. Ewan P. W., Lachmann P. J. IgG synthesis within the brain in multiple sclerosis and subacute sclerosing panencephalitis. Clin Exp Immunol. 1979 Feb;35(2):227–235. [PMC free article] [PubMed] [Google Scholar]
  9. Haire M. Significance of virus antibodies in multiple sclerosis. Br Med Bull. 1977 Jan;33(1):40–44. doi: 10.1093/oxfordjournals.bmb.a071394. [DOI] [PubMed] [Google Scholar]
  10. Hall W. W., Lamb R. A., Choppin P. W. Measles and subacute sclerosing panencephalitis virus proteins: lack of antibodies to the M protein in patients with subacute sclerosing panencephalitis. Proc Natl Acad Sci U S A. 1979 Apr;76(4):2047–2051. doi: 10.1073/pnas.76.4.2047. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Imagawa D. T. Relationships among measles, canine distemper and rinderpest viruses. Prog Med Virol. 1968;10:160–193. [PubMed] [Google Scholar]
  12. Joseph B. S., Oldstone M. B. Antibody-induced redistribution of measles virus antigens on the cell surface. J Immunol. 1974 Oct;113(4):1205–1209. [PubMed] [Google Scholar]
  13. Jotkowitz S. Multiple sclerosis and exposure to house pets. JAMA. 1977 Aug 22;238(8):854–854. [PubMed] [Google Scholar]
  14. Krakowka S., Koestner A. Canine distemper virus and multiple sclerosis. Lancet. 1978 May 27;1(8074):1127–1128. doi: 10.1016/s0140-6736(78)90302-1. [DOI] [PubMed] [Google Scholar]
  15. Kurland L., Brian D. Multiple sclerosis and canine pets. Ann Neurol. 1978 Feb;3(2):97–100. doi: 10.1002/ana.410030202. [DOI] [PubMed] [Google Scholar]
  16. Lincoln S. D., Gorham J. R., Ott R. L., Hegreberg G. A. Etiologic studies of old dog encephalitis. I. Demonstration of canine distemper viral antigen in the brain in two cases. Vet Pathol. 1971;8(1):1–8. doi: 10.1177/030098587100800101. [DOI] [PubMed] [Google Scholar]
  17. McCullough B., Krakowka S., Koestner A. Experimental canine distemper virus-induced demyelination. Lab Invest. 1974 Sep;31(3):216–222. [PubMed] [Google Scholar]
  18. McCullough B., Krakowka S., Koestner A. Experimental canine distemper virus-induced lymphoid depletion. Am J Pathol. 1974 Jan;74(1):155–170. [PMC free article] [PubMed] [Google Scholar]
  19. Nathanson N., Palsson P. A., Gudmundsson G. Multiple sclerosis and canine distemper in Iceland. Lancet. 1978 Nov 25;2(8100):1127–1129. doi: 10.1016/s0140-6736(78)92279-1. [DOI] [PubMed] [Google Scholar]
  20. Norrby E., Link H., Olsson J. E. Measles virus antibodies in multiple sclerosis. Comparison of antibody titers in cerebrospinal fluid and serum. Arch Neurol. 1974 Apr;30(4):285–292. doi: 10.1001/archneur.1974.00490340013002. [DOI] [PubMed] [Google Scholar]
  21. Norrby E., Link H., Olsson J. E., Panelius M., Salmi A., Vandvik B. Comparison of antibodies against different viruses in cerebrospinal fluid and serum samples from patients with multiple sclerosis. Infect Immun. 1974 Oct;10(4):688–694. doi: 10.1128/iai.10.4.688-694.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Oldstone M. B., Tishon A. Immunologic injury in measles virus infection. IV. Antigens modulation and abrogation oflymphocyte lysis of virus-infected cells. Clin Immunol Immunopathol. 1978 Jan;9(1):55–62. doi: 10.1016/0090-1229(78)90120-4. [DOI] [PubMed] [Google Scholar]
  23. Poskanzer D. C., Prenney L. B., Sheridan J. L. House pets and multiple sclerosis. Lancet. 1977 Jun 4;1(8023):1204–1204. doi: 10.1016/s0140-6736(77)92739-8. [DOI] [PubMed] [Google Scholar]
  24. Prasad I., Broome J. D., Pertschuk L. P., Gupta J., Cook A. W. Recovery of Paramyxovirus from the jejunum of patients with multiple sclerosis. Lancet. 1977 May 28;1(8022):1117–1119. doi: 10.1016/s0140-6736(77)92381-9. [DOI] [PubMed] [Google Scholar]
  25. Salmi A. A. Virus antibodies in patients with multiple sclerosis. Ann Clin Res. 1973 Oct;5(5):319–329. [PubMed] [Google Scholar]
  26. Tanaka R., Iwasaki Y., Koprowski H. Intracisternal virus-like particles in brain of a multiple sclerosis patient. J Neurol Sci. 1976 May;28(1):121–126. doi: 10.1016/0022-510X(76)90053-8. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Tourtellotte W. On cerebrospinal fluid immunoglobulin-G (IgG) quotients in multiple sclerosis and other diseases. A review and a new formula to estimate the amount of IgG synthesized per day by the central nervous system. J Neurol Sci. 1970 Mar;10(3):279–304. doi: 10.1016/0022-510x(70)90156-5. [DOI] [PubMed] [Google Scholar]
  28. Vandvik B., Norrby E., Nordal H. J., Degré M. Oligoclonal measles virus-specific IgG antibodies isolated from cerebrospinal fluids, brain extracts, and sera from patients with subacute sclerosing panencephalitis and multiple sclerosis. Scand J Immunol. 1976;5(8):979–992. doi: 10.1111/j.1365-3083.1976.tb03050.x. [DOI] [PubMed] [Google Scholar]
  29. Vandvik B., Norrby E. Oligoclonal IgG antibody response in the central nervous system to different measles virus antigens in subacute sclerosing panencephalitis. Proc Natl Acad Sci U S A. 1973 Apr;70(4):1060–1063. doi: 10.1073/pnas.70.4.1060. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES