Abstract
Total lymphocyte counts and the number of SmIg positive and E-rosetting cells in the blood of 103 healthy Brazilian children between birth and eight years and fifty-one healthy adults were compared. A high number of total lymphocytes were observed during the first year of life and decreased thereafter to reach adult values by the age of seven years. The proportion of SmIg positive cells was high in the newborn, further increased during the second trimester and remained unchanged up to the end of the first year of life. Thereafter they gradually decreased reaching adult levels by the age of three years. The percentage of E-rosetting cells was low in the newborn and young children and increased after the second year of life to reach adult levels by the age of seven years. The absolute number of both lymphocyte subpopulations changes with approximately the same pattern as the total lymphocyte counts.
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- Asma G. E., Schuit H. R., Hijmans W. The determination of numbers of T and B lymphocytes in the blood of children and adults by the direct immunofluorescence technique. Clin Exp Immunol. 1977 Aug;29(2):286–294. [PMC free article] [PubMed] [Google Scholar]
- Ben-Zwi A., Galili U., Russell A., Schlesinger M. Age-associated changes in subpopulations of human lymphocytes. Clin Immunol Immunopathol. 1977 Jan;7(1):139–149. doi: 10.1016/0090-1229(77)90038-1. [DOI] [PubMed] [Google Scholar]
- Campbell A. C., Waller C., Wood J., Aynsley-Green A., Yu V. Lymphocyte subpopulations in the blood of newborn infants. Clin Exp Immunol. 1974 Dec;18(4):469–482. [PMC free article] [PubMed] [Google Scholar]
- Clot J., Charmasson E., Brochier J. Age-dependent changes of human blood lymphocyte subpopulations. Clin Exp Immunol. 1978 May;32(2):346–351. [PMC free article] [PubMed] [Google Scholar]
- Diaz-Jauanen E., Strickland R. G., Williams R. C. Studies of human lymphocytes in the newborn and the aged. Am J Med. 1975 May;58(5):620–628. doi: 10.1016/0002-9343(75)90497-0. [DOI] [PubMed] [Google Scholar]
- Fauci A. S. Mechanisms of corticosteroid action on lymphocyte subpopulations. I. Redistribution of circulating T and b lymphocytes to the bone marrow. Immunology. 1975 Apr;28(4):669–680. [PMC free article] [PubMed] [Google Scholar]
- Fleisher T. A., Luckasen J. R., Sabad A., Gehrtz R. C., Kersey J. H. T and B lymphocyte subpopulations in children. Pediatrics. 1975 Feb;55(2):162–165. [PubMed] [Google Scholar]
- Fröland S. S., Natvig J. B. Lymphocytes with membrane-bound immunoglobulin (B-lymphocytes) in new-born babies. Clin Exp Immunol. 1972 Aug;11(4):495–505. [PMC free article] [PubMed] [Google Scholar]
- Lobo P. I., Westervelt F. B., Horwitz D. A. Identification of two populations of immunoglobulin-bearing lymphocytes in man. J Immunol. 1975 Jan;114(1 Pt 1):116–119. [PubMed] [Google Scholar]
- Smith M. A., Evans J., Steel C. M. Age-related variation in proportion of circulating T cells. Lancet. 1974 Oct 19;2(7886):922–924. doi: 10.1016/s0140-6736(74)91130-1. [DOI] [PubMed] [Google Scholar]
- Vossen J. M. Membrane-associated immunoglobulin determinants on bone marrow and blood lymphocytes in the pediatric age group and on fetal tissues. Ann N Y Acad Sci. 1975 Jun 30;254:262–279. doi: 10.1111/j.1749-6632.1975.tb29176.x. [DOI] [PubMed] [Google Scholar]