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. 1974 Nov;18(3):295–301.

Impaired responsiveness of lymphocytes in patients with systemic lupus erythematosus

Nicole Suciu-Foca, J A Buda, Traute Thiem, K Reemtsma
PMCID: PMC1537988  PMID: 4283364

Abstract

Cellular immune responsiveness, as measured by lymphocyte transformation in one-way mixed leucocyte cultures (MLC) and in phytohaemagglutinin (PHA) stimulated cultures was evaluated in forty patients with systemic lupus erythematosus (SLE) and in seventy-four normal controls. The effect produced by sera from these subjects on in vitro lymphocyte reactivity was tested on autologous cells and on homologous responding cells from a constant panel of ten healthy volunteers.

The reactivity of lymphocytes from SLE patients to PHA and to a battery of allogeneic cells was significantly lower than that of normal controls.

Sera from some SLE patients inhibited the MLC reactions, while in other cases a distinct stimulatory effect was found.

It is suggested that virus-induced modifications of normal histocompatibility antigens cause the appearance of blocking antibody that might bind to the surface of T lymphocytes, impairing their function.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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