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. 1974 Dec;18(4):491–498.

Shared antigenic determinants between human brain and human T-cell line

A Takada, Yumiko Takada, U Ito, J Minowada
PMCID: PMC1538003  PMID: 4143285

Abstract

Rabbits were immunized with MOLT cells (T cells) and RPMI number 1788 (B cells) to get respective antisera. These sera were absorbed with human liver, human brain, or various B cells (RPMI number 1788, SOMMER-B cell, B-35M cells and B-411 cells). The results indicate that the cytotoxicity of rabbit anti-MOLT serum against MOLT cells could be absorbed to some extent with human liver and various B cells but not completely. Human brain could completely absorb anti-MOLT activity from rabbit anti-MOLT serum. Human brain could not remove anti-B-cell activity from rabbit anti-RPMI number 1788 (B cells). Rat brain did not remove anti-MOLT activity from anti-MOLT serum.

These data suggest that human brain has antigenic determinants identical or very similar to those found on MOLT cells and thus possibly human thymocytes.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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