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. 1980 Feb;39(2):289–296.

Lymphocytotoxins in leprosy and in asymptomatic hepatitis B virus infection.

S Serjeantson, P Dry
PMCID: PMC1538069  PMID: 7389201

Abstract

Serum lymphocytotoxic antibodies (LCAs) were detected in 67% of Papua New Guinean lepromatous leprosy patients who were persistent carriers of hepatitis B surface antigen (HBsAg). Lymphocytotoxins were not associated with asymptomatic HBsAg in either healthy controls or tuberculoid leprosy patients. It was apparent that, although HBsAg itself is a poor indicator of in vitro lymphocytotoxicity, when the antigen occurred in a host with impaired immune response, lymphocytotoxicity, when the antigen occurred in a host with impaired immune response, lymphocytotoxicity was enhanced. In contrast to this finding, lepromatous leprosy patients without HBsAg had significantly depressed LCA production in comparison with tuberculoid patients and controls. The interaction between leprosy and hepatitis B virus was highly significant (P = 0.001) in an analysis of variance of cytotoxicity scores. It is proposed that the previously reported equivocal results regarding autoantibodies in leprosy patients may be explained by this unusual interaction between lepromatous leprosy and hepatitis B virus infection.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bjorvatn B., Barnetson R. S., Kronvall G., Zubler R. H., Lambert P. H. Immune complexes and complement hypercatabolism in patients with leprosy. Clin Exp Immunol. 1976 Dec;26(3):388–396. [PMC free article] [PubMed] [Google Scholar]
  2. Blumberg B. S., Melartin L., Lechat M., Guinto R. S. Association between lepromatous leprosy and Australia antigen. Lancet. 1967 Jul 22;2(7508):173–176. doi: 10.1016/s0140-6736(67)90003-7. [DOI] [PubMed] [Google Scholar]
  3. Booth P. B., Jenkins W. J., Marsh W. L. Anti-I-t: a new antibody of the I-blood-group system occurring in certain Melanesian sera. Br J Haematol. 1966 May;12(3):341–344. doi: 10.1111/j.1365-2141.1966.tb05641.x. [DOI] [PubMed] [Google Scholar]
  4. Bortolotti F., Realdi G., Diodati G., Fattovich G. Antibody dependent cellular cytotoxicity (ADCC) in acute hepatitis B and in chronic active hepatitis. Clin Exp Immunol. 1978 Aug;33(2):211–216. [PMC free article] [PubMed] [Google Scholar]
  5. DeHoratius R. J., Messner R. P. Lymphocytotoxic antibodies in family members of patients with systemic lupus erythematosus. J Clin Invest. 1975 Jun;55(6):1254–1258. doi: 10.1172/JCI108044. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Dehoratius R. J., Henderson C., Strickland R. G. Lymphocytotoxins in acute and chronic hepatitis. Characterization and relationship to changes in circulating T lymphocytes. Clin Exp Immunol. 1976 Oct;26(1):21–27. [PMC free article] [PubMed] [Google Scholar]
  7. Huang S. W., Lattos D. B., Nelson D. B., Reeb K., Hong R. Antibody-associated lymphotoxin in acute infection. J Clin Invest. 1973 May;52(5):1033–1040. doi: 10.1172/JCI107268. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Iverson G. M. Ability of CBA mice to produce anti-idiotypic sera to 5563 myeloma protein. Nature. 1970 Jul 18;227(5255):273–274. doi: 10.1038/227273a0. [DOI] [PubMed] [Google Scholar]
  9. Kingham J. G., Rassam S., Ganguly N., Mcguire M. J., Nasrat B., Holgate S. T., Triger D. R., Wright R. DNA-binding antibodies and hepatitis B markers in acute and chronic liver disease. Clin Exp Immunol. 1978 Aug;33(2):204–210. [PMC free article] [PubMed] [Google Scholar]
  10. Korsmeyer S. J., Williams R. C., Jr, Wilson I. D., Strickland R. G. Lymphocytotoxic antibody in inflammatory bowel disease. A family study. N Engl J Med. 1975 Nov 27;293(22):1117–1120. doi: 10.1056/NEJM197511272932203. [DOI] [PubMed] [Google Scholar]
  11. Kreisler M. J., Hirata A. A., Terasaki P. I. Cytotoxins in disease. 3. Antibodies against lymphocytes produced by vaccination. Transplantation. 1970 Nov;10(5):411–415. [PubMed] [Google Scholar]
  12. Matthews L. J., Trautman J. R. Clinical and serological profiles in leprosy. Lancet. 1965 Nov 6;2(7419):915–917. doi: 10.1016/s0140-6736(65)92899-0. [DOI] [PubMed] [Google Scholar]
  13. Mayer S., Falkenrodt A., Tongio M. M. Cold lymphocytotoxins in infections and parasitic infestations. Tissue Antigens. 1973;3(6):431–438. doi: 10.1111/j.1399-0039.1973.tb00513.x. [DOI] [PubMed] [Google Scholar]
  14. McAdam K. P., Fudenberg H. H., Michaeli D. Antibodies to collagen in patients with leprosy. Clin Immunol Immunopathol. 1978 Jan;9(1):16–21. doi: 10.1016/0090-1229(78)90115-0. [DOI] [PubMed] [Google Scholar]
  15. McKearn T. J., Stuart F. P., Fitch F. W. Anti-idiotypic antibody in rat transplantation immunity. I. Production of anti-idiotypic antibody in animals repeatedly immunized with alloantigens. J Immunol. 1974 Dec;113(6):1876–1882. [PubMed] [Google Scholar]
  16. Naito S., Mickey M. R., Hirata A., Terasaki P. I. Autolymphocytotoxins following immunization by pregnancy, transplantation, and disease. Tissue Antigens. 1971;1(5):219–228. doi: 10.1111/j.1399-0039.1971.tb00099.x. [DOI] [PubMed] [Google Scholar]
  17. Nisonoff A., Bangasser S. A. Immunological suppression of idiotypic specificities. Transplant Rev. 1975;27:100–134. doi: 10.1111/j.1600-065x.1975.tb00186.x. [DOI] [PubMed] [Google Scholar]
  18. Ooi B. S., Orlina A. R., Pesce A. J., Mendoza N., Masaitis L., Pollak V. E. Lymphocytotoxic antibodies in patients with systemic lupus erythematosus. Clin Exp Immunol. 1974 Jun;17(2):237–243. [PMC free article] [PubMed] [Google Scholar]
  19. Pellegrino M. A., Ferrone S., Theofilopoulos A. N. Isolation of human T and B lymphocytes by rosette formation with 2-aminoethylisothiquronium bromide (AET) -treated sheep red blood cells with monkey red blood cells. J Immunol Methods. 1976;11(3-4):273–279. doi: 10.1016/0022-1759(76)90120-4. [DOI] [PubMed] [Google Scholar]
  20. Petchclai B., Chuthanondh R., Rungruong S., Ramasoota T. Autoantibodies in leprosy among Thai patients. Lancet. 1973 Jun 30;1(7818):1481–1482. doi: 10.1016/s0140-6736(73)91816-3. [DOI] [PubMed] [Google Scholar]
  21. Rosenberg E. B., Strickland G. T., Yang S. L., Whalen G. E. IgM antibodies to red cells and autoimmune anemia in patients with malaria. Am J Trop Med Hyg. 1973 Mar;22(2):146–152. doi: 10.4269/ajtmh.1973.22.146. [DOI] [PubMed] [Google Scholar]
  22. Schocket A. L., Weiner H. L. Lymphocytotoxic antibodies in family members of patients with multiple sclerosis. Lancet. 1978 Mar 18;1(8064):571–573. doi: 10.1016/s0140-6736(78)91023-1. [DOI] [PubMed] [Google Scholar]
  23. Serjeantson S., Woodfield D. G. Immune response of leprosy patients to hepatitis B virus. Am J Epidemiol. 1978 Apr;107(4):321–327. doi: 10.1093/oxfordjournals.aje.a112547. [DOI] [PubMed] [Google Scholar]
  24. Strickland R. G., Friedler E. M., Henderson C. A., Wilson I. D., Williams R. D., Jr Serum lymphocytotoxins in inflammatory bowel disease. Studies of frequency and specificity for lymphocyte subpopulations. Clin Exp Immunol. 1975 Sep;21(3):384–393. [PMC free article] [PubMed] [Google Scholar]
  25. TERASAKI P. I., MCCLELLAND J. D. MICRODROPLET ASSAY OF HUMAN SERUM CYTOTOXINS. Nature. 1964 Dec 5;204:998–1000. doi: 10.1038/204998b0. [DOI] [PubMed] [Google Scholar]
  26. Terasaki P. I., Mottironi V. D., Barnett E. V. Cytotoxins in disease. Autocytotoxins in lupus. N Engl J Med. 1970 Oct 1;283(14):724–728. doi: 10.1056/NEJM197010012831403. [DOI] [PubMed] [Google Scholar]
  27. Vyas G. N., Shulman N. R. Hemagglutination assay for antigen and antibody associated with viral hepatitis. Science. 1970 Oct 16;170(3955):332–333. doi: 10.1126/science.170.3955.332. [DOI] [PubMed] [Google Scholar]
  28. Wager O. Immunological aspects of leprosy with special reference to autoimmune diseases. Bull World Health Organ. 1969;41(6):793–804. [PMC free article] [PubMed] [Google Scholar]
  29. Winfield J. B., Winchester R. J., Kunkel H. G. Association of cold-reactive antilymphocyte antibodies with lymphopenia in systemic lupus erythematosus. Arthritis Rheum. 1975 Nov-Dec;18(6):587–594. doi: 10.1002/art.1780180609. [DOI] [PubMed] [Google Scholar]

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