Abstract
Unpurified peripheral blood leucocytes or purified eosinophils and neutrophils from patients with schistosomiasis and from normal individuals were compared for their ability to interact with antibody coated schistosomula of Schistosoma mansoni. There was no difference in the ability of buffy coat cells or neutrophils from patients and from normal individuals to mediate antibody-dependent 51Cr release from labelled schistosomula. However, eosinophils from patients were significantly better than those from normal individuals in causing antibody-dependent 51Cr release. This enhanced activity of eosinophils from patients with schistosomiasis was found to correlate with the intensity of their infection as judged by faecal egg counts. Eosinophils from patients also contained a higher proportion of cells with detectable Fc receptors than those from normal individuals. It is suggested that the difference in the behaviour of eosinophils from patients and from normals may reflect an 'activated' state of these cells in the infected individuals.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Brandtzaeg P. Rhodamine conjugates:specific and nonspecific binding properties in immunohistochemistry. Ann N Y Acad Sci. 1975 Jun 30;254:35–54. doi: 10.1111/j.1749-6632.1975.tb29154.x. [DOI] [PubMed] [Google Scholar]
- Butterworth A. E., David J. R., Franks D., Mahmoud A. A., David P. H., Sturrock R. F., Houba V. Antibody-dependent eosinophil-mediated damage to 51Cr-labeled schistosomula of Schistosoma mansoni: damage by purieid eosinophils. J Exp Med. 1977 Jan 1;145(1):136–150. doi: 10.1084/jem.145.1.136. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Butterworth A. E., Sturrock R. F., Houba V., Mahmoud A. A., Sher A., Rees P. H. Eosinophils as mediators of antibody-dependent damage to schistosomula. Nature. 1975 Aug 28;256(5520):727–729. doi: 10.1038/256727a0. [DOI] [PubMed] [Google Scholar]
- Butterworth A. E., Sturrock R. F., Houba V., Rees P. H. Antibody-dependent cell-mediated damage to schistosomula in vitro. Nature. 1974 Dec 6;252(5483):503–505. doi: 10.1038/252503a0. [DOI] [PubMed] [Google Scholar]
- Glauert A. M., Butterworth A. E. Morphological evidence for the ability of eosinophils to damage antibody-coated schistosomula. Trans R Soc Trop Med Hyg. 1977;71(5):392–395. doi: 10.1016/0035-9203(77)90036-0. [DOI] [PubMed] [Google Scholar]
- Glauert A. M., Butterworth A. E., Sturrock R. F., Houba V. The mechansim of antibody-dependent, eosinophil-mediated damage to schistosomula of Schistosoma mansoni in vitro: a study by phase-contrast and electron microscopy. J Cell Sci. 1978 Dec;34:173–192. doi: 10.1242/jcs.34.1.173. [DOI] [PubMed] [Google Scholar]
- Mahmoud A. A., Kellermeyer R. W., Warren K. S. Production of monospecific rabbit antihuman eosinophil serums and demonstration of a blocking phenomenon. N Engl J Med. 1974 Feb 21;290(8):417–420. doi: 10.1056/NEJM197402212900801. [DOI] [PubMed] [Google Scholar]
- Sher A., Smithers S. R., Mackenzie P. Passive transfer of acquired resistance to Schistosoma mansoni in laboratory mice. Parasitology. 1975 Jun;70(Pt 3):347–357. doi: 10.1017/s0031182000052124. [DOI] [PubMed] [Google Scholar]
- Sturrock R. F., Butterworth A. E., Houba V. Schistosoma mansoni in the baboon (Papio anubis): parasitological responses of Kenyan baboons to different exposures of a local parasite strain. Parasitology. 1976 Dec;73(3):239–252. doi: 10.1017/s003118200004693x. [DOI] [PubMed] [Google Scholar]
- Tai P. C., Spry C. J. Studies on blood eosinophils. I. Patients with a transient eosinophilia. Clin Exp Immunol. 1976 Jun;24(3):415–422. [PMC free article] [PubMed] [Google Scholar]
- Vadas M. A., David J. R., Butterworth A., Pisani N. T., Siongok T. A. A new method for the purification of human eosinophils and neutrophils, and a comparison of the ability of these cells to damage schistosomula of Schistosoma mansoni. J Immunol. 1979 Apr;122(4):1228–1236. [PubMed] [Google Scholar]