Abstract
Ten patients with chronic lymphatic leukaemia (CLL) were injected with the antigen phichi174 intravenously on two occasions to test their capacity for antibody production. Nine out of ten patients failed to develop a primary response, and five out of ten failed to develop a secondary response. Only one out of the ten of the secondary responses fell within the normal range. There was evidence of defective switching from IgM to IgG antibody in two out of three cases in which the immunoglobulin class of antibody in the secondary response was determined. The severity of the immunoparesis in CLL is related to the severity of the disease.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BARR M., FAIRLEY G. H. Circulating antibodies in reticuloses. Lancet. 1961 Jun 17;1(7190):1305–1310. doi: 10.1016/s0140-6736(61)90237-9. [DOI] [PubMed] [Google Scholar]
- CONE L., UHR J. W. IMMUNOLOGICAL DEFICIENCY DISORDERS ASSOCIATED WITH CHRONIC LYMPHOCYTIC LEUKEMIA AND MULTIPLE MYELOMA. J Clin Invest. 1964 Dec;43:2241–2248. doi: 10.1172/JCI105098. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LARSON D. L., TOMLINSON L. J. Quantitative antibody studies in man. II. The relation of the level of serum proteins to antibody production. J Lab Clin Med. 1952 Jan;39(1):129–133. [PubMed] [Google Scholar]
- LARSON D. L., TOMLINSON L. J. Quantitative antibody studies in man. III. Antibody response in leukemia and other malignant lymphomata. J Clin Invest. 1953 Apr;32(4):317–321. doi: 10.1172/JCI102741. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Ochs H. D., Davis S. D., Wedgwood R. J. Immunologic responses to bacteriophage phi-X 174 in immunodeficiency diseases. J Clin Invest. 1971 Dec;50(12):2559–2568. doi: 10.1172/JCI106756. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Peacock D. B., Jones J. V., Gough M. The immune response to thetaX 174 in man. I. Primary and secondary antibody production in normal adults. Clin Exp Immunol. 1973 Apr;13(4):497–513. [PMC free article] [PubMed] [Google Scholar]