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. 1975 Oct;22(1):30–34.

T and B lymphocytes in multiple sclerosis.

R P Lisak, A I Levinson, B Zweiman, N I Abdou
PMCID: PMC1538349  PMID: 1082395

Abstract

The percentage and total number of E and EAC rosettes, as indicators of T and B lymphocytes respectively, were studied in the blood of subjects with multiple sclerosis (MS) and normals. MS patients in acute exacerbation were found to have a decrease in E rosettes and an increase in EAC rosettes. The relationship of these findings to the pathogenesis of MS is unclear; several possible pathogenetic implications are considered.

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Selected References

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  1. Abrahamsohn I., Nilsson U. R., Abdou N. I. Relationship of immunoglobulin to complement receptors of human B cells. J Immunol. 1974 May;112(5):1931–1938. [PubMed] [Google Scholar]
  2. Aisenberg A. C., Bloch K. J. Immunoglobulins on the surface of neoplastic lymphocytes. N Engl J Med. 1972 Aug 10;287(6):272–276. doi: 10.1056/NEJM197208102870603. [DOI] [PubMed] [Google Scholar]
  3. BORNSTEIN M. B., APPEL S. H. TISSUE CULTURE STUDIES OF DEMYELINATION. Ann N Y Acad Sci. 1965 Mar 31;122:280–286. doi: 10.1111/j.1749-6632.1965.tb20212.x. [DOI] [PubMed] [Google Scholar]
  4. Bentwich Z., Kunkel H. G. Specific properties of human B and T lymphocytes and alterations in disease. Transplant Rev. 1973;16:29–50. doi: 10.1111/j.1600-065x.1973.tb00116.x. [DOI] [PubMed] [Google Scholar]
  5. Böyum A. Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. Scand J Clin Lab Invest Suppl. 1968;97:77–89. [PubMed] [Google Scholar]
  6. Ciongoli A. K., Platz P., Dupont B., Svejgaard A., Fog T., Jersild C. Letter: Lack of antigen response to myxoviruses in multiple sclerosis. Lancet. 1973 Nov 17;2(7838):1147–1147. [PubMed] [Google Scholar]
  7. Cooper M. D., Keightley R. G., Wu L. Y., Lawton A. R., 3rd Developmental defects of T and B cell lines in humans. Transplant Rev. 1973;16:51–84. doi: 10.1111/j.1600-065x.1973.tb00117.x. [DOI] [PubMed] [Google Scholar]
  8. Daniels R. P., Rowlands D. T., Jr Detection of human lymphocytes bearing complement receptors after in vitro modification with mercaptoethanol. Transplantation. 1974 Jan 1;17(1):126–128. doi: 10.1097/00007890-197401000-00020. [DOI] [PubMed] [Google Scholar]
  9. Davis L. E., Hersh E. M., Curtis J. E., Lynch R. E., Ziegler D. K., Neumann J. W., Chin T. D. Immune status of patients with multiple sclerosis. Analysis of primary and established immune responses in 24 patients. Neurology. 1972 Oct;22(10):989–997. doi: 10.1212/wnl.22.9.989. [DOI] [PubMed] [Google Scholar]
  10. Dwyer J. M., Bullock W. E., Fields J. P. Disturbance of the blood T:B lymphocyte ratio in lepromatous leprosy. Clinical and immunologic correlations. N Engl J Med. 1973 May 17;288(20):1036–1039. doi: 10.1056/NEJM197305172882002. [DOI] [PubMed] [Google Scholar]
  11. Frick E., Stickl H., Zinn K. H. Lymphocytentransformation bei Multipler Sklerose. Nachweis einer Sensibilisierung gegen basisches Markscheidenprotein. Klin Wochenschr. 1974 Mar 1;52(5):238–245. doi: 10.1007/BF01468597. [DOI] [PubMed] [Google Scholar]
  12. Jensen M. K. Lymphocyte transformation in multiple sclerosis. Acta Neurol Scand. 1968;44(2):200–206. doi: 10.1111/j.1600-0404.1968.tb05566.x. [DOI] [PubMed] [Google Scholar]
  13. Johansen K. S., Johansen T. S., Talmage D. W. T cell rosette formation in primates, pigs, and guinea pigs. The influence of immunosuppresive agents. J Allergy Clin Immunol. 1974 Aug;54(2):86–93. doi: 10.1016/0091-6749(74)90036-0. [DOI] [PubMed] [Google Scholar]
  14. Jondal M., Holm G., Wigzell H. Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells. J Exp Med. 1972 Aug 1;136(2):207–215. doi: 10.1084/jem.136.2.207. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Keith H. I., Currey H. L. Rosette formation by peripheral blood lymphocytes in rheumatoid arthritis. Ann Rheum Dis. 1973 May;32(3):202–207. doi: 10.1136/ard.32.3.202. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Knowles M., Hughes D., Caspary E. A., Field E. J. Lymphocyte transformation in multiple sclerosis. Inhibition of unstimulated thymidine uptake by a serum factor. Lancet. 1968 Dec 7;2(7580):1207–1209. doi: 10.1016/s0140-6736(68)91691-7. [DOI] [PubMed] [Google Scholar]
  17. Kongshavn P. A., Gold P., Shuster J., Colquhoun B., Freedman S. O. Ability of anti-brain heteroantisera to distinguish thymus-derived lymphocytes in various species. Clin Immunol Immunopathol. 1974 Sep;3(1):1–15. doi: 10.1016/0090-1229(74)90019-1. [DOI] [PubMed] [Google Scholar]
  18. Kuwert E., Bertrams J. Leukocyte iso- and autoantibodies in multiple sclerosis (MS) with special regard to complement-dependent cold-reacting auto-lymphocytotoxins (CoCoCy). Eur Neurol. 1972;7(1):65–73. doi: 10.1159/000114413. [DOI] [PubMed] [Google Scholar]
  19. Lisak R. P., Behan P. O., Zweiman B., Shetty T. Cell-mediated immunity to myelin basic protein in acute disseminated encephalomyelitis. Neurology. 1974 Jun;24(6):560–564. doi: 10.1212/wnl.24.6.560. [DOI] [PubMed] [Google Scholar]
  20. Lisak R. P., Zwiman B., Norman M. Antimyelin antibodies in neurologic diseases. Immunofluorescent demonstration. Arch Neurol. 1975 Mar;32(3):163–167. doi: 10.1001/archneur.1975.00490450043005. [DOI] [PubMed] [Google Scholar]
  21. Papamichail M., Holborow E. J., Keith H. I., Currey H. L. Subpopulations of human peripheral blood lymphocytes distinguished by combined rosette formation and membrane immunofluorescence. Lancet. 1972 Jul 8;2(7767):64–66. doi: 10.1016/s0140-6736(72)91553-x. [DOI] [PubMed] [Google Scholar]
  22. Paterson P. Y. Multiple sclerosis: an immunologic reassessment. J Chronic Dis. 1973 Mar;26(3):119–126. doi: 10.1016/0021-9681(73)90085-4. [DOI] [PubMed] [Google Scholar]
  23. Ross G. D., Rabellino E. M., Polley M. J., Grey H. M. Combined studies of complement receptor and surface immunoglobulin-bearing cells and sheep erythrocyte rosette-forming cells in normal and leukemic human lymphocytes. J Clin Invest. 1973 Feb;52(2):377–385. doi: 10.1172/JCI107194. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Scheinberg M. A., Cathcart E. S. B cell and T cell lymphopenia in systemic lupus erythematosus. Cell Immunol. 1974 May;12(2):309–314. doi: 10.1016/0008-8749(74)90083-5. [DOI] [PubMed] [Google Scholar]
  25. Shevach E. M., Jaffe E. S., Green I. Receptors for complement and immunoglobulin on human and animal lymphoid cells. Transplant Rev. 1973;16:3–28. doi: 10.1111/j.1600-065x.1973.tb00115.x. [DOI] [PubMed] [Google Scholar]
  26. Smith M. A., Evans J., Steel C. M. Age-related variation in proportion of circulating T cells. Lancet. 1974 Oct 19;2(7886):922–924. doi: 10.1016/s0140-6736(74)91130-1. [DOI] [PubMed] [Google Scholar]
  27. Stjernholm R. L., Wheelock E. F., van den Noort S. A lymphotoxic factor in multiple sclerosis serum. J Reticuloendothel Soc. 1970 Oct;8(4):334–341. [PubMed] [Google Scholar]
  28. Utermohlen V., Zabriskie J. B. Letter: Suppressed cellular immunity to measles antigen in multiple-sclerosis patients. Lancet. 1973 Nov 17;2(7838):1147–1148. [PubMed] [Google Scholar]
  29. Weiner L. P., Johnson R. T., Herndon R. M. Viral infections and demyelinating diseases. N Engl J Med. 1973 May 24;288(21):1103–1110. doi: 10.1056/NEJM197305242882106. [DOI] [PubMed] [Google Scholar]
  30. Williams R. C., Jr, DeBoard J. R., Mellbye O. J., Messner R. P., Lindström F. D. Studies of T- and B-lymphocytes in patients with connective tissue diseases. J Clin Invest. 1973 Feb;52(2):283–295. doi: 10.1172/JCI107184. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Wybran J., Fudenberg H. H. Thymus-derived rosette-forming cells in various human disease states: cancer, lymphoma, bacterial and viral infections, and other diseases. J Clin Invest. 1973 May;52(5):1026–1032. doi: 10.1172/JCI107267. [DOI] [PMC free article] [PubMed] [Google Scholar]

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