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. 1976 Jan;23(1):154–165.

Immunodeficiency in the chicken. IV. An immunological study of infectious bursal disease.

J Ivanyi, R Morris
PMCID: PMC1538367  PMID: 177236

Abstract

Chickens inoculated orally with infectious bursal disease virus (IBDV) 1 day after hatching subsequently showed a 50% incidence of immunodeficiency but little mortality. Antibody responses against IBDV and to immunization with sheep red blood cells (SRBC) or human serum albumin (HSA) were suppressed. Serum IgG concentration was decreased while IgM occurred exclusively in its 7S monomeric form (mIgM). An allotypic marker of chicken IgM (Mla) was lacking in mIgM derived from IBDV-infected birds. The loss of Mla occurred gradually in several birds between 3 and 12 weeks after perinatal infection. Inoculation of IBDV into chickens 3 weeks after hatching resulted in 50% mortality level but little immunodeficiency. Paradoxically, the serum IgG concentration was elevated, in comparison with normal birds. Histology of the bursa showed permanent hypo- or aplasia of follicles irrespective of the age of infection. The results suggest that bursal but not peripheral B cells are targets for IBDV, and immunodeficiency results from impaired peripheral seeding of B cells in infected juvenile chickens.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Almeida J. D., Morris R. Antigenically-related viruses associated with infectious bursal disease. J Gen Virol. 1973 Sep;20(3):369–375. doi: 10.1099/0022-1317-20-3-369. [DOI] [PubMed] [Google Scholar]
  2. Blaese R. M., Weiden P. L., Koski I., Dooley N. Infectious agammaglobulinemia: transmission of immunodeficiency with grafts of agammaglobulinemic cells. J Exp Med. 1974 Oct 1;140(4):1097–1101. doi: 10.1084/jem.140.4.1097. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bloch-Shtacher N., Hirschhorn K., Uhr J. W. The response of lymphocytes from non-immunized humans to antigen-antibody complexes. Clin Exp Immunol. 1968 Nov;3(9):889–899. [PMC free article] [PubMed] [Google Scholar]
  4. Cheville N. F. Studies on the pathogenesis of Gumboro disease in the bursa of Fabricius, spleen, and thymus of the chicken. Am J Pathol. 1967 Oct;51(4):527–551. [PMC free article] [PubMed] [Google Scholar]
  5. Cooper M. D., Cain W. A., Van Alten P. J., Good R. A. Development and function of the immunoglobulin producing system. I. Effect of bursectomy at different stages of development on germinal centers, plasma cells, immunoglobulins and antibody production. Int Arch Allergy Appl Immunol. 1969;35(3):242–252. [PubMed] [Google Scholar]
  6. Cooper M. D., Purchase H. G., Bockman D. E., Gathings W. E. Studies on the nature of the abnormality of B cell differentiation in avian lymphoid leukosis: production of heterogeneous IgM by tumor cells. J Immunol. 1974 Oct;113(4):1210–1222. [PubMed] [Google Scholar]
  7. Faragher J. T., Allan W. H., Cullen G. A. Immunosuppressive effect of the infectious bursal agent in the chicken. Nat New Biol. 1972 May 24;237(73):118–119. doi: 10.1038/newbio237118a0. [DOI] [PubMed] [Google Scholar]
  8. Gorczynski R. M., Miller R. G., Phillips R. A. Initiation of antibody production to sheep erythrocytes in vitro: replacement of the requirement for T-cells with a cell-free factor isolated from cultures of lymphoid cells. J Immunol. 1972 Feb;108(2):547–551. [PubMed] [Google Scholar]
  9. Hanna M. G., Jr, Nettesheim P., Peters L. C. Evidence of functional microenvironments in lymphatic tissue response to antigen. Nat New Biol. 1971 Aug;232(33):204–206. doi: 10.1038/newbio232204a0. [DOI] [PubMed] [Google Scholar]
  10. Hirai K., Shimakura S., Kawamoto E., Taguchi F., Kim S. T., Chang C. N., Iritani Y. The immunodepressive effect of infectious bursal disease virus in chickens. Avian Dis. 1974 Jan-Mar;18(1):50–57. [PubMed] [Google Scholar]
  11. Hitchner S. B. Infectivity of infectious bursal disease virus for embryonating eggs. Poult Sci. 1970 Mar;49(2):511–516. doi: 10.3382/ps.0490511. [DOI] [PubMed] [Google Scholar]
  12. Ivanyi J. Immunodeficiency in the chicken. I. Disparity in suppression of antibody responses to various antigens following surgical bursectomy. Immunology. 1975 Jun;28(6):1007–1013. [PMC free article] [PubMed] [Google Scholar]
  13. Ivanyi J. Immunodeficiency in the chicken. II. Production of monomeric IgM following testosterone treatment or infection with Gumboro disease. Immunology. 1975 Jun;28(6):1015–1021. [PMC free article] [PubMed] [Google Scholar]
  14. Ivanyi J. Sequential recruitment of antibody class-committed B lymphocytes during ontogeny. Eur J Immunol. 1973 Dec;3(12):789–793. doi: 10.1002/eji.1830031210. [DOI] [PubMed] [Google Scholar]
  15. Kösters J., Becht H., Rudolph R. Properties of the infectious bursal agent of chicken (IBA). Med Microbiol Immunol. 1972;157(4):291–298. doi: 10.1007/BF02121121. [DOI] [PubMed] [Google Scholar]
  16. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  17. Möller G. Induction of DNA synthesis in normal human lymphocyte cultures by antigen-antibody complexes. Clin Exp Immunol. 1969 Jan;4(1):65–82. [PMC free article] [PubMed] [Google Scholar]
  18. Oppenheim J. J. Modulation of in vitro lymphocyte transformation by antibodies: enhancement by antigen-antibody complexes and inhibition by antibody excess. Cell Immunol. 1972 Mar;3(3):341–360. doi: 10.1016/0008-8749(72)90243-2. [DOI] [PubMed] [Google Scholar]
  19. Peterson R. D., Purchase H. G., Burmester B. R., Cooper M. D., Good R. A. Relationships among visceral lymphomatosis, bursa of Fabricius, and bursa-dependent lymphoid tissue of the chicken. J Natl Cancer Inst. 1966 Apr;36(4):585–598. doi: 10.1093/jnci/36.4.585. [DOI] [PubMed] [Google Scholar]
  20. Rosenthal M., Stastny P., Ziff M. Stimulation of gamma-globulin synthesis and specific antibody production by a factor released by activated lymphocytes. J Immunol. 1973 Oct;111(4):1119–1127. [PubMed] [Google Scholar]
  21. WINTERFIELD R. W., HITCHNER S. B. Etiology of an infectious nephritis-nephrosis syndrome of chickens. Am J Vet Res. 1962 Nov;23:1273–1279. [PubMed] [Google Scholar]
  22. Yoshiki T., Mellors R. C., Strand M., August J. T. The viral envelope glycoprotein of murine leukemia virus and the pathogenesis of immune complex glomerulonephritis of New Zealand mice. J Exp Med. 1974 Oct 1;140(4):1011–1027. doi: 10.1084/jem.140.4.1011. [DOI] [PMC free article] [PubMed] [Google Scholar]

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