Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1976 Jan;23(1):47–55.

B and T lymphocytes in Hodgkin's disease. Analysis at diagnosis and following therapy.

K J Gajl-Peczalska, C D Bloomfield, H Sosin, J H Kersey
PMCID: PMC1538370  PMID: 1083318

Abstract

B and T lymphocytes were studied in the blood and lymph nodes of fifty patients with Hodgkin's disease. At diagnosis, most patients (77%) had normal percentages of circulating B and T lymphocytes. Most patients (60%) also showed normal percentages of B and T lymphocytes in involved lymph nodes. Splenectomy had no effect on circulating B and T lymphocytes in four of five patients studied 2 weeks postoperatively. Seventeen patients were studied before and after treatment to determine the effect of therapy. Very high percentages of B lymphocytes were found in patients studied following radiotherapy. It appears that the known defects in cell-mediated immunity in Hodgkin's disease are not expressed as significant abnormalities in B-or T-lymphocyte ratios in blood or lymphoid tissues at diagnosis. The proliferation of B lymphocytes following radiotherapy could represent a compensatory mechanism to cell-mediated deficiency or a loss of normal suppressor activity of T lymphocytes.

Full text

PDF
47

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AISENBERG A. C. Studies on delayed hypersensitivity in Hodgkin's disease. J Clin Invest. 1962 Nov;41:1964–1970. doi: 10.1172/JCI104654. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Aisenberg A. C., Long J. C. Lymphocyte surface characteristics in malignant lymphoma. Am J Med. 1975 Mar;58(3):300–306. doi: 10.1016/0002-9343(75)90595-1. [DOI] [PubMed] [Google Scholar]
  3. Aiuti F., Wigzell H. A study on human T lymphocytes, their function and frequency in some diseases. Adv Exp Med Biol. 1973;29(0):307–314. doi: 10.1007/978-1-4615-9017-0_45. [DOI] [PubMed] [Google Scholar]
  4. Andersen E. Depletion of thymus dependent lymphocytes in Hodgkin's disease. Scand J Haematol. 1974;12(4):263–269. doi: 10.1111/j.1600-0609.1974.tb00208.x. [DOI] [PubMed] [Google Scholar]
  5. Beavers E. M. Letter: Lung cancer in chloromethyl methyl ether workers. N Engl J Med. 1974 Apr 25;290(17):971–972. doi: 10.1056/NEJM197404252901718. [DOI] [PubMed] [Google Scholar]
  6. Biniaminov M., Ramot B. Letter: Possible T-lymphocyte origin of Reed-Sternberg cells. Lancet. 1974 Mar 2;1(7853):368–368. doi: 10.1016/s0140-6736(74)93138-9. [DOI] [PubMed] [Google Scholar]
  7. Braylan R. C., Jaffe E. S., Berard C. W. Letter: Surface characteristics of Hodgkin's lymphoma cells. Lancet. 1974 Nov 30;2(7892):1328–1329. doi: 10.1016/s0140-6736(74)90198-6. [DOI] [PubMed] [Google Scholar]
  8. Carbone P. P., Kaplan H. S., Musshoff K., Smithers D. W., Tubiana M. Report of the Committee on Hodgkin's Disease Staging Classification. Cancer Res. 1971 Nov;31(11):1860–1861. [PubMed] [Google Scholar]
  9. Chase M. W. Delayed-type hypersensitivity and the immunology of Hodgkin's disease, with a parallel examination of sarcoidosis. Cancer Res. 1966 Jun;26(6):1097–1120. [PubMed] [Google Scholar]
  10. Cohnen G., Augener W., Brittinger G., Douglas S. D. Rosette-forming lymphocytes in Hodgkin's disease. N Engl J Med. 1973 Oct 18;289(16):863–863. doi: 10.1056/NEJM197310182891616. [DOI] [PubMed] [Google Scholar]
  11. Cohnen G., Augener W., König E., Brittinger G., Douglas S. D. B lymphocytes in Hodgkin's disease. N Engl J Med. 1973 Jan 18;288(3):161–162. doi: 10.1056/nejm197301182880319. [DOI] [PubMed] [Google Scholar]
  12. Corder M. P., Young R. C., Brown R. S., DeVita V. T. Phytohemagglutinin-induced lymphocyte transformation: the relationship to prognosis of Hodgkin's disease. Blood. 1972 May;39(5):595–601. [PubMed] [Google Scholar]
  13. Eltringham J. R., Kaplan H. S. Impaired delayed-hypersensitivity responses in 154 patients with untreated Hodgkin's disease. Natl Cancer Inst Monogr. 1973 May;36:107–115. [PubMed] [Google Scholar]
  14. Engeset A., Fröland S. S., Bremer K., Host H. Blood lymphocytes in Hodgkin's disease. Increase of B-lymphocytes following extended field irradiation. Scand J Haematol. 1973;11(3):195–200. doi: 10.1111/j.1600-0609.1973.tb00116.x. [DOI] [PubMed] [Google Scholar]
  15. Falletta J. M., Ramanujam N., Starling K. A., Fernbach D. J. Ig-positive lymphocytes in Hodgkin's disease. N Engl J Med. 1973 Mar 15;288(11):581–582. [PubMed] [Google Scholar]
  16. Fröland S. S. Binding of sheep erythrocytes to human lymphocytes. A probable marker of T lymphocytes. Scand J Immunol. 1972;1(3):269–280. doi: 10.1111/j.1365-3083.1972.tb01818.x. [DOI] [PubMed] [Google Scholar]
  17. Gajl-Peczalska K. J., Biggar W. D., Park B. H., Good R. A. B lymphocytes in DiGeorge syndrome. Lancet. 1972 Jun 17;1(7764):1344–1344. doi: 10.1016/s0140-6736(72)91078-1. [DOI] [PubMed] [Google Scholar]
  18. Gajl-Peczalska K. J., Hansen J. A., Bloomfield C. D., Good R. A. B lymphocytes in untreated patients with malignant lymphoma and Hodgkin's disease. J Clin Invest. 1973 Dec;52(12):3064–3073. doi: 10.1172/JCI107505. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Gajl-Peczalska K. J., Lim S. D., Jacobson R. R., Good R. A. B lymphocytes in lepromatous leprosy. N Engl J Med. 1973 May 17;288(20):1033–1035. doi: 10.1056/NEJM197305172882001. [DOI] [PubMed] [Google Scholar]
  20. Gajl-Peczalska K. J., Park B. H., Biggar W. D., Good R. A. B and T lymphocytes in primary immunodeficiency disease in man. J Clin Invest. 1973 Apr;52(4):919–928. doi: 10.1172/JCI107257. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Gallmeier W. M., Bruntsch U., Pfeiffer R., Bestek U., Schmidt C. G. T and B lymphocytes in Hodgkin's disease. Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1973 Dec 6;80(3):247–254. doi: 10.1007/BF00284325. [DOI] [PubMed] [Google Scholar]
  22. Halie M. R., Eibergen R., van der Broek A. A., Nieweg H. O. Letter: The spleen in Hodgkin's disease. Lancet. 1974 Nov 2;2(7888):1078–1078. doi: 10.1016/s0140-6736(74)92172-2. [DOI] [PubMed] [Google Scholar]
  23. Han T., Sokal J. E. Lymphocyte response to phytohemagglutinin in Hodgkin's disease. Am J Med. 1970 Jun;48(6):728–734. doi: 10.1016/s0002-9343(70)80008-0. [DOI] [PubMed] [Google Scholar]
  24. Hersh E. M., Oppenheim J. J. Impaired in vitro lymphocyte transformation in Hodgkin's disease. N Engl J Med. 1965 Nov 4;273(19):1006–1012. doi: 10.1056/NEJM196511042731903. [DOI] [PubMed] [Google Scholar]
  25. KELLY W. D., LAMB D. L., VARCO R. L., GOOD R. A. An investigation of Hodgkin's disease with respect to the problem of homotransplantation. Ann N Y Acad Sci. 1960 May 31;87:187–202. doi: 10.1111/j.1749-6632.1960.tb23192.x. [DOI] [PubMed] [Google Scholar]
  26. Kadin M. E., Newcom S. R., Gold S. B., Stites D. P. Letter: Origin of Hodgkin's cell. Lancet. 1974 Jul 20;2(7873):167–168. doi: 10.1016/s0140-6736(74)91602-x. [DOI] [PubMed] [Google Scholar]
  27. Kaur J., Spiers A. S., Catovsky D., Galton D. A. Increase of T lymphocytes in the spleen in Hodgkin's disease. Lancet. 1974 Oct 5;2(7884):800–802. doi: 10.1016/s0140-6736(74)91070-8. [DOI] [PubMed] [Google Scholar]
  28. Kersey J. H., Sabad A., Gajl-Peczalska K., Hallgren H. M., Yunis E. J., Nesbit M. E. Acute lymphoblastic leukemic cells with T (thymus-derived) lymphocyte markers. Science. 1973 Dec 28;182(4119):1355–1356. doi: 10.1126/science.182.4119.1355. [DOI] [PubMed] [Google Scholar]
  29. Leech J. Immunoglobulin-positive Reed Sternberg cells in Hodgkin's disease. Lancet. 1973 Aug 4;2(7823):265–266. doi: 10.1016/s0140-6736(73)93173-5. [DOI] [PubMed] [Google Scholar]
  30. Levy R., Kaplan H. S. Impaired lymphocyte function in untreated Hodgkin's disease. N Engl J Med. 1974 Jan 24;290(4):181–186. doi: 10.1056/NEJM197401242900402. [DOI] [PubMed] [Google Scholar]
  31. Longmire R. L., McMillan R., Yelenosky R., Armstrong S., Lang J. E., Craddock C. G. In vitro splenic IgG synthesis in Hodgkin's disease. N Engl J Med. 1973 Oct 11;289(15):763–767. doi: 10.1056/NEJM197310112891501. [DOI] [PubMed] [Google Scholar]
  32. Matchett K. M., Huang A. T., Kremer W. B. Impaired lymphocyte transformation in Hodgkin's disease. Evidence for depletion of circulating t-lymphocytes. J Clin Invest. 1973 Aug;52(8):1908–1917. doi: 10.1172/JCI107374. [DOI] [PMC free article] [PubMed] [Google Scholar]
  33. Michlmayr G., Huber C., Fink U., Falkensammer M., Huber H. T-Lymphozyten in peripherem Blut und Lymphknoten bei lymphatischen Systemerkrankungen. Schweiz Med Wochenschr. 1974 Jun 8;104(23):815–820. [PubMed] [Google Scholar]
  34. Order S. E., Hellman S. Pathogenesis of Hodgkin's disease. Lancet. 1972 Mar 11;1(7750):571–573. doi: 10.1016/s0140-6736(72)90360-1. [DOI] [PubMed] [Google Scholar]
  35. Papamichail M., Holborow E. J., Keith H. I., Currey H. L. Subpopulations of human peripheral blood lymphocytes distinguished by combined rosette formation and membrane immunofluorescence. Lancet. 1972 Jul 8;2(7767):64–66. doi: 10.1016/s0140-6736(72)91553-x. [DOI] [PubMed] [Google Scholar]
  36. Ramot B., Many A., Biniaminov M., Aghai E. Thymus-derived lymphocyte (T-cell) depletion in Hodgkin's disease. Isr J Med Sci. 1973 May;9(5):657–659. [PubMed] [Google Scholar]
  37. SCHIER W. W., ROTH A., OSTROFF G., SCHRIFT M. H. Hodgkin's disease and immunity. Am J Med. 1956 Jan;20(1):94–99. doi: 10.1016/0002-9343(56)90176-0. [DOI] [PubMed] [Google Scholar]
  38. Taylor C. R. The nature of Reed-Sternberg cells and other malignant "reticulum" cells. Lancet. 1974 Oct 5;2(7884):802–807. doi: 10.1016/s0140-6736(74)91071-x. [DOI] [PubMed] [Google Scholar]
  39. Young R. C., Corder M. P., Berard C. W., DeVita V. T. Immune alterations in Hodgkin's disease. Effect of delayed hypersensitivity and lymphocyte transformation on course and survival. Arch Intern Med. 1973 Mar;131(3):446–454. doi: 10.1001/archinte.131.3.446. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES