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. 1999 Jan;40(1):40–48.

Seroepidemiology of undifferentiated fever in feedlot calves in western Canada.

C W Booker 1, P T Guichon 1, G K Jim 1, O C Schunicht 1, R J Harland 1, P S Morley 1
PMCID: PMC1539654  PMID: 9919366

Abstract

The relationships between 4 bacterial and 3 viral antibody titers and morbidity (undifferentiated fever (UF)) and mortality were investigated in recently weaned beef calves. Blood samples from 100 animals that required treatment for UF (Cases) and 100 healthy control animals (Controls) were obtained: upon arrival at the feedlot (Arrival), at the time of selection as a Case or Control (Selection), and at approximately 33 d of the feeding period (Convalescent). Seroconversion to Pasteurella haemolytica antileukotoxin was associated with an increased risk of UF (OR = 2.83); however, seroconversion to bovine herpesvirus-1 G-IV glycoprotein was associated with a decreased risk of UF (OR = 0.43). Higher Arrival bovine viral diarrhea virus antibody titer was associated with a decreased risk of UF (OR = 0.83). Increases in Mycoplasma alkalescens antibody titer after Arrival were associated with an increased risk of UF (OR = 1.10). Higher Arrival Haemophilus somnus antibody titer and increases in Haemophilus somnus antibody titer after Arrival were both associated with a decreased risk of UF (OR = 0.76 and OR = 0.78). The odds of overall mortality (OR = 5.09) and hemophilosis mortality (OR = 11.31) in Cases were significantly (P < 0.05) higher than in the Controls. Higher Arrival bovine herpesvirus-1 antibody titer was associated with an increased risk of mortality (OR = 1.30). Protective immunity to Pasteurella haemolytica antileukotoxin, Haemophilus somnus, bovine herpesvirus-1 G-IV glycoprotein, bovine viral diarrhea virus, and Mycoplasma spp. may be necessary to reduce the occurrence of UF. Animals with UF are at an increased risk of overall and hemophilosis mortality.

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Selected References

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  1. Adegboye D. S., Halbur P. G., Nutsch R. G., Kadlec R. G., Rosenbusch R. F. Mycoplasma bovis-associated pneumonia and arthritis complicated with pyogranulomatous tenosynovitis in calves. J Am Vet Med Assoc. 1996 Aug 1;209(3):647–649. [PubMed] [Google Scholar]
  2. Allen J. W., Viel L., Bateman K. G., Nagy E., Røsendal S., Shewen P. E. Serological titers to bovine herpesvirus 1, bovine viral diarrhea virus, parainfluenza 3 virus, bovine respiratory syncytial virus and Pasteurella haemolytica in feedlot calves with respiratory disease: associations with bacteriological and pulmonary cytological variables. Can J Vet Res. 1992 Oct;56(4):281–288. [PMC free article] [PubMed] [Google Scholar]
  3. Babiuk L. A., L'Italien J., van Drunen Littel-van den Hurk S., Zamb T., Lawman J. P., Hughes G., Gifford G. A. Protection of cattle from bovine herpesvirus type I (BHV-1) infection by immunization with individual viral glycoproteins. Virology. 1987 Jul;159(1):57–66. doi: 10.1016/0042-6822(87)90347-3. [DOI] [PubMed] [Google Scholar]
  4. Booker C. W., Jim G. K., Guichon P. T., Schunicht O. C., Thorlakson B. E., Lockwood P. W. Evaluation of florfenicol for the treatment of undifferentiated fever in feedlot calves in western Canada. Can Vet J. 1997 Sep;38(9):555–560. [PMC free article] [PubMed] [Google Scholar]
  5. Chima J. C., Wilkie B. N., Nielsen K. H., Ruhnke H. L., Truscott R. B., Maxie G., Chick B. Synovial immunoglobulin and antibody in vaccinated and nonvaccinated calves challenged with Mycoplasma bovis. Can J Comp Med. 1981 Jan;45(1):92–96. [PMC free article] [PubMed] [Google Scholar]
  6. Church T. L., Radostits O. M. A retrospective survey of diseases of feedlot cattle in Alberta. Can Vet J. 1981 Feb;22(2):27–30. [PMC free article] [PubMed] [Google Scholar]
  7. Conlon J. A., Gallo G. F., Shewen P. E., Adlam C. Comparison of protection of experimentally challenged cattle vaccinated once or twice with a Pasteurella haemolytica bacterial extract vaccine. Can J Vet Res. 1995 Jul;59(3):179–182. [PMC free article] [PubMed] [Google Scholar]
  8. Durham P. J., Hassard L. E., Van Donkersgoed J. Serological studies of infectious bovine rhinotracheitis, parainfluenza 3, bovine viral diarrhea, and bovine respiratory syncytial viruses in calves following entry to a bull test station. Can Vet J. 1991 Jul;32(7):427–429. [PMC free article] [PubMed] [Google Scholar]
  9. Frank G. H., Smith P. C. Prevalence of Pasteurella haemolytica in transported calves. Am J Vet Res. 1983 Jun;44(6):981–985. [PubMed] [Google Scholar]
  10. Guichon T., Jim K., Pritchard J. Alberta. Mortality due to Haemophilus somnus in calves. Can Vet J. 1989 May;30(5):435–435. [PMC free article] [PubMed] [Google Scholar]
  11. Harland R. J., Jim G. K., Guichon P. T., Townsend H. G., Janzen E. D. Efficacy of parenteral antibiotics for disease prophylaxis in feedlot calves. Can Vet J. 1991 Mar;32(3):163–168. [PMC free article] [PubMed] [Google Scholar]
  12. Harland R. J., Potter A. A., van Drunen-Littel-van den Hurk S., Van Donkersgoed J., Parker M. D., Zamb T. J., Janzen E. D. The effect of subunit or modified live bovine herpesvirus-1 vaccines on the efficacy of a recombinant Pasteurella haemolytica vaccine for the prevention of respiratory disease in feedlot calves. Can Vet J. 1992 Nov;33(11):734–741. [PMC free article] [PubMed] [Google Scholar]
  13. Howard C. J., Stott E. J., Thomas L. H., Gourlay R. N., Taylor G. Protection against respiratory disease in calves induced by vaccines containing respiratory syncytial virus, parainfluenza type 3 virus, Mycoplasma bovis and M dispar. Vet Rec. 1987 Oct 17;121(16):372–376. doi: 10.1136/vr.121.16.372. [DOI] [PubMed] [Google Scholar]
  14. Jim G. K., Booker C. W., Guichon P. T. Comparison of a combination of oxfendazole and fenthion versus ivermectin in feedlot calves. Can Vet J. 1992 Sep;33(9):599–604. [PMC free article] [PubMed] [Google Scholar]
  15. Kelly A. P., Janzen E. D. A review of morbidity and mortality rates and disease occurrence in north american feedlot cattle. Can Vet J. 1986 Dec;27(12):496–500. [PMC free article] [PubMed] [Google Scholar]
  16. Langform E. V. Comments on "update on pasteurellosis in young cattle". Can Vet J. 1980 Sep;21(9):265–265. [PMC free article] [PubMed] [Google Scholar]
  17. Martin S. W., Bateman K. G., Shewen P. E., Rosendal S., Bohac J. E. The frequency, distribution and effects of antibodies, to seven putative respiratory pathogens, on respiratory disease and weight gain in feedlot calves in Ontario. Can J Vet Res. 1989 Jul;53(3):355–362. [PMC free article] [PubMed] [Google Scholar]
  18. Martin S. W., Bateman K. G., Shewen P. E., Rosendal S., Bohac J. G., Thorburn M. A group level analysis of the associations between antibodies to seven putative pathogens and respiratory disease and weight gain in Ontario feedlot calves. Can J Vet Res. 1990 Jun;54(3):337–342. [PMC free article] [PubMed] [Google Scholar]
  19. Martin S. W., Bohac J. G. The association between serological titers in infectious bovine rhinotracheitis virus, bovine virus diarrhea virus, parainfluenza-3 virus, respiratory syncytial virus and treatment for respiratory disease in Ontario feedlot calves. Can J Vet Res. 1986 Jul;50(3):351–358. [PMC free article] [PubMed] [Google Scholar]
  20. Martin S. W., Meek A. H., Davis D. G., Thomson R. G., Johnson J. A., Lopez A., Stephens L., Curtis R. A., Prescott J. F., Rosendal S. Factors associated with mortality in feedlot cattle: the Bruce County Beef Cattle Project. Can J Comp Med. 1980 Jan;44(1):1–10. [PMC free article] [PubMed] [Google Scholar]
  21. Radostits O. M., Janzen E., Doige C., Jim K. Alberta. Mycoplasma arthritis in feedlot cattle. Can Vet J. 1988 Jun;29(6):531–532. [PMC free article] [PubMed] [Google Scholar]
  22. Ribble C. S., Jim G. K., Janzen E. D. Efficacy of immunization of feedlot calves with a commercial Haemophilus somnus bacterin. Can J Vet Res. 1988 Apr;52(2):191–198. [PMC free article] [PubMed] [Google Scholar]
  23. Ribble C. S., Meek A. H., Janzen E. D., Guichon P. T., Jim G. K. Effect of time of year, weather, and the pattern of auction market sales on fatal fibrinous pneumonia (shipping fever) in calves in a large feedlot in Alberta (1985-1988). Can J Vet Res. 1995 Jul;59(3):167–172. [PMC free article] [PubMed] [Google Scholar]
  24. Ribble C. S., Meek A. H., Jim G. K., Guichon P. T. The pattern of fatal fibrinous pneumonia (shipping fever) affecting calves in a large feedlot in Alberta (1985-1988). Can Vet J. 1995 Dec;36(12):753–757. [PMC free article] [PubMed] [Google Scholar]
  25. Rosendal S., Martin S. W. The association between serological evidence of mycoplasma infection and respiratory disease in feedlot calves. Can J Vet Res. 1986 Apr;50(2):179–183. [PMC free article] [PubMed] [Google Scholar]
  26. Shewen P. E., Wilkie B. N. Antibody titers to Pasteurella haemolytica A1 in Ontario beef cattle. Can J Comp Med. 1982 Oct;46(4):354–356. [PMC free article] [PubMed] [Google Scholar]
  27. Shewen P. E., Wilkie B. N. Pasteurella haemolytica cytotoxin neutralizing activity in sera from Ontario beef cattle. Can J Comp Med. 1983 Oct;47(4):497–498. [PMC free article] [PubMed] [Google Scholar]
  28. Shewen P. E., Wilkie B. N. Vaccination of calves with leukotoxic culture supernatant from Pasteurella haemolytica. Can J Vet Res. 1988 Jan;52(1):30–36. [PMC free article] [PubMed] [Google Scholar]
  29. Taylor L. F., Van Donkersgoed J., Dubovi E. J., Harland R. J., van den Hurk J. V., Ribble C. S., Janzen E. D. The prevalence of bovine viral diarrhea virus infection in a population of feedlot calves in western Canada. Can J Vet Res. 1995 Apr;59(2):87–93. [PMC free article] [PubMed] [Google Scholar]
  30. Thomson R. G., Chander S., Savan M., Fox M. L. Investigation of factors of probable significance in the pathogenesis of pneumonic pasteurellosis in cattle. Can J Comp Med. 1975 Apr;39(2):194–207. [PMC free article] [PubMed] [Google Scholar]
  31. Van Donkersgoed J., Janzen E. D., Harland R. J. Epidemiological features of calf mortality due to hemophilosis in a large feedlot. Can Vet J. 1990 Dec;31(12):821–825. [PMC free article] [PubMed] [Google Scholar]
  32. Van Donkersgoed J., Janzen E. D., Potter A. A., Harland R. J. The occurrence of Haemophilus somnus in feedlot calves and its control by postarrival prophylactic mass medication. Can Vet J. 1994 Sep;35(9):573–580. [PMC free article] [PubMed] [Google Scholar]
  33. Van Donkersgoed J., McCartney D., van Drunen Littel-van den Hurk S. Efficacy of an experimental BHV-1 subunit gIV vaccine in beef calves challenged with BHV-1 in aerosol. Can J Vet Res. 1996 Jan;60(1):55–58. [PMC free article] [PubMed] [Google Scholar]
  34. Van Donkersgoed J., Potter A. A., Mollison B., Harland R. J. The effect of a combined Pasteurella haemolytica and Haemophilus somnus vaccine and a modified-live bovine respiratory syncytial virus vaccine against enzootic pneumonia in young beef calves. Can Vet J. 1994 Apr;35(4):239–241. [PMC free article] [PubMed] [Google Scholar]
  35. Van Donkersgoed J., van den Hurk J. V., McCartney D., Harland R. J. Comparative serological response in calves to eight commercial vaccines against infectious bovine rhinotracheitis, parainfluenza-3, bovine respiratory syncytial, and bovine viral diarrhea viruses. Can Vet J. 1991 Dec;32(12):727–733. [PMC free article] [PubMed] [Google Scholar]
  36. van Drunen Littel-van den Hurk S., Parker M. D., Massie B., van den Hurk J. V., Harland R., Babiuk L. A., Zamb T. J. Protection of cattle from BHV-1 infection by immunization with recombinant glycoprotein gIV. Vaccine. 1993;11(1):25–35. doi: 10.1016/0264-410x(93)90336-v. [DOI] [PubMed] [Google Scholar]

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