Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1976 Nov;26(2):222–227.

Peripheral blood lymphocyte populations in chronic liver disease.

H C Thomas, M Freni, J Sanchez-Tapias, D de Villiers, S Jain, S Sherlock
PMCID: PMC1540859  PMID: 1086752

Abstract

Mature T lymphocyte concentrations are reduced, null cell concentrations are increased, and Fc receptor bearing (B and K) lymphocyte concentrations are normal, in the peripheral blood of patients with chronic hepatocellular or cholestatic liver disease. Some null cells can be stimulated by either thymosin or levamisole to form rosettes with sheep erythrocytes. These changes are present in viral, alcohol associated and 'autoimmune' liver disease and are therefore probably secondary phenomena relating to liver damage.

Full text

PDF
223

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allison A. C., Denman A. M., Barnes R. D. Cooperating and controlling functions of thymus-derived lymphocytes in relation to autoimmunity. Lancet. 1971 Jul 17;2(7716):135–140. doi: 10.1016/s0140-6736(71)92306-3. [DOI] [PubMed] [Google Scholar]
  2. Bernstein I. M., Webster K. H., Williams R. C., Jr, Strickland R. G. Reduction in circulating T lymphocytes in alcoholic liver disease. Lancet. 1974 Aug 31;2(7879):488–490. doi: 10.1016/s0140-6736(74)92015-7. [DOI] [PubMed] [Google Scholar]
  3. CORRIDAN M. THE THYMUS IN HEPATIC CIRRHOSIS. J Clin Pathol. 1963 Sep;16:445–447. doi: 10.1136/jcp.16.5.445. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Chisari F. V., Edgington T. S. Human T lymphocyte "E" rosette function. I. A process modulated by intracellular cyclic AMP. J Exp Med. 1974 Oct 1;140(4):1122–1126. doi: 10.1084/jem.140.4.1122. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cook G. C., Mulligan R., Sherlock S. Controlled prospective trial of corticosteroid therapy in active chronic hepatitis. Q J Med. 1971 Apr;40(158):159–185. doi: 10.1093/oxfordjournals.qjmed.a067264. [DOI] [PubMed] [Google Scholar]
  6. DeHoratius R. J., Strickland R. G., Williams R. C., Jr T and B lymphocytes in acute and chronic hepatitis. Clin Immunol Immunopathol. 1974 Apr;2(3):353–360. doi: 10.1016/0090-1229(74)90053-1. [DOI] [PubMed] [Google Scholar]
  7. Dudley F. J., Fox R. A., Sherlock S. Cellular immunity and hepatitis-associated, Australia antigen liver disease. Lancet. 1972 Apr 1;1(7753):723–726. doi: 10.1016/s0140-6736(72)90234-6. [DOI] [PubMed] [Google Scholar]
  8. Hadden J. W., Coffey R. G., Hadden E. M., Lopez-Corrales E., Sunshine G. H. Effects of levamisole and imidazole on lymphocyte proliferation and cyclic nucleotide levels. Cell Immunol. 1975 Nov;20(1):98–103. doi: 10.1016/0008-8749(75)90088-x. [DOI] [PubMed] [Google Scholar]
  9. MACLACHLAN M. J., RODNAN G. P., COOPER W. M., FENNELL R. H., Jr CHRONIC ACTIVE ("LUPOID") HEPATITIS; A CLINICAL, SEROLOGICAL, AND PATHOLOGICAL STUDY OF 20 PATIENTS. Ann Intern Med. 1965 Mar;62:425–462. doi: 10.7326/0003-4819-62-3-425. [DOI] [PubMed] [Google Scholar]
  10. MacLennan I. C. Antibody in the induction and inhibition of lymphocyte cytotoxicity. Transplant Rev. 1972;13:67–90. doi: 10.1111/j.1600-065x.1972.tb00060.x. [DOI] [PubMed] [Google Scholar]
  11. Scheinberg M. A., Cathcart E. S., Goldstein A. L. Thymosin-induced reduction of "null cells" in peripheral-blood lymphocytes of patients with systemic lupus erythematosus. Lancet. 1975 Feb 22;1(7904):424–426. doi: 10.1016/s0140-6736(75)91491-9. [DOI] [PubMed] [Google Scholar]
  12. Thomas H. C., McSween R. N., White R. G. Role of the liver in controlling the immunogenicity of commensal bacteria in the gut. Lancet. 1973 Jun 9;1(7815):1288–1291. doi: 10.1016/s0140-6736(73)91300-7. [DOI] [PubMed] [Google Scholar]
  13. Thomas H. C., Ryan C. J., Benjamin I. S., Blumgart L. H., MacSween R. N. The immune response in cirrhotic rats. The induction of tolerance to orally administered protein antigens. Gastroenterology. 1976 Jul;71(1):114–117. [PubMed] [Google Scholar]
  14. White R. G., Boyd J. F. The effect of measles on the thymus and other lymphoid tissues. Clin Exp Immunol. 1973 Mar;13(3):343–357. [PMC free article] [PubMed] [Google Scholar]
  15. Zatz M. M., Lance E. M. The distribution of 51Cr-labeled lymphocytes into antigen-stimulated mice. Lymphocyte trapping. J Exp Med. 1971 Jul 1;134(1):224–241. doi: 10.1084/jem.134.1.224. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES