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. 1977 Jan;27(1):85–91.

Cell-mediated immunity in an ageing population.

J P Girard, M Paychère, M Cuevas, B Fernandes
PMCID: PMC1540893  PMID: 321161

Abstract

Eight hundred and eighty patients hospitalized in a geriatric hospital were routinely tested with 2, 10, 30 and 100 i.u. tuberculin. Among these, fifty-four patients were selected on the basis of negative skin tests and absence of evident diseases interfering with the function of the immune apparatus. A battery of tests analysing cell-mediated immunity was applied to those fifty-four patients. It appears that elderly patients having a negative test to 100 i.u. tuberculin show very infrequent sensitization to three other thymus-dependent antigens. The capacity of this selected population to become sensitized to DNCB is poor (20%). Furthermore they exhibit a low per cent of peripheral blood T cells (36%) and a poor capacity to respond in vitro to mitogens such as PHA. Testing the in vitro response to a battery of antigens demonstrates a good correlation with the results of the skin tests. Finally the leucocytes of 25% of this selected population failed to produce LIF in vitro in the presence of PHA. These results suggest not only an absolute decrease in the population of circulating T lymphocytes in those elderly humans; but very likely, at least in some cases, a functional impairment of T cells.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AISENBERG A. C. Studies on delayed hypersensitivity in Hodgkin's disease. J Clin Invest. 1962 Nov;41:1964–1970. doi: 10.1172/JCI104654. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Axelrod A. E. Immune processes in vitamin deficiency states. Am J Clin Nutr. 1971 Feb;24(2):265–271. doi: 10.1093/ajcn/24.2.265. [DOI] [PubMed] [Google Scholar]
  3. Das K. C., Hoffbrand A. V. Studies of folate uptake by phytohaemagglutinin-stimulated lymphocytes. Br J Haematol. 1970 Aug;19(2):203–221. doi: 10.1111/j.1365-2141.1970.tb01617.x. [DOI] [PubMed] [Google Scholar]
  4. GALVIN H. J. LIVER DAMAGE AND FLUOTHANE. Lancet. 1964 May 23;1(7343):1164–1164. doi: 10.1016/s0140-6736(64)91844-6. [DOI] [PubMed] [Google Scholar]
  5. GROSS L. IMMUNOLOGICAL DEFECT IN AGED POPULATION AND ITS RELATIONSHIP TO CANCER. Cancer. 1965 Feb;18:201–204. doi: 10.1002/1097-0142(196502)18:2<201::aid-cncr2820180211>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
  6. Girard J. P., Cattin S., Cuevas M. Immunological mechanisms and diagnostic tests in allergic drug reactions. Ann Clin Res. 1976 Apr;8(2):74–84. [PubMed] [Google Scholar]
  7. Hallgren H. M., Buckley C. E., 3rd, Gilbertsen V. A., Yunis E. J. Lymphocyte phytohemagglutinin responsiveness, immunoglobulins and autoantibodies in aging humans. J Immunol. 1973 Oct;111(4):1101–1107. [PubMed] [Google Scholar]
  8. Ippoliti G., Marini G., Casirola G., Invernizzi R. Letter: T lymphocytes and immunoglobulins in the aged. Lancet. 1974 Oct 19;2(7886):953–954. doi: 10.1016/s0140-6736(74)91157-x. [DOI] [PubMed] [Google Scholar]
  9. Joris F., Girard J. P. Immune response in aged and young subjects, following administration of large doses of tuberculin. Int Arch Allergy Appl Immunol. 1975;48(5):584–596. doi: 10.1159/000231347. [DOI] [PubMed] [Google Scholar]
  10. Miller S. D., Jones H. E. Correlation of lymphocyte transformation with tuberculin skin-test sensitivity. Am Rev Respir Dis. 1973 Apr;107(4):530–538. doi: 10.1164/arrd.1973.107.4.530. [DOI] [PubMed] [Google Scholar]
  11. Prieto Valtuena J., Gonzalez Guilabert M. I., Del Pozo Perez M. A., Del Pozo Crespo F., Velasco Alonso R. Autoimmunity, immunoglobulins and T lymphocyte population in old age. Biomedicine. 1973 Jul 20;19(7):301–303. [PubMed] [Google Scholar]
  12. Roberts-Thomson I. C., Whittingham S., Youngchaiyud U., Mackay I. R. Ageing, immune response, and mortality. Lancet. 1974 Aug 17;2(7877):368–370. doi: 10.1016/s0140-6736(74)91755-3. [DOI] [PubMed] [Google Scholar]
  13. Smith M. A., Evans J., Steel C. M. Age-related variation in proportion of circulating T cells. Lancet. 1974 Oct 19;2(7886):922–924. doi: 10.1016/s0140-6736(74)91130-1. [DOI] [PubMed] [Google Scholar]
  14. White G. B., Lasheen R. M., Turner G. C. Rapid detection of Australia antigen by cross-over electrophoresis. Lancet. 1970 Aug 15;2(7668):368–368. doi: 10.1016/s0140-6736(70)92905-3. [DOI] [PubMed] [Google Scholar]
  15. Willkens R. F., Whitaker R. R., Anderson R. V., Berven D. Significance of antinuclear factors in older persons. Ann Rheum Dis. 1967 Jul;26(4):306–310. doi: 10.1136/ard.26.4.306. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Yunis E. J., Greenberg L. J. Immunopathology of aging. Fed Proc. 1974 Sep;33(9):2017–2019. [PubMed] [Google Scholar]

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