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. 1976 Dec;26(3):381–387.

Antibody-mediated immunity in CFW mice infected with Mycobacterium lepraemurium. Humoral immune response in murine leprosy.

O Rojas-Espinosa, M Casoluengo-Méndez, G V Díaz
PMCID: PMC1540956  PMID: 795574

Abstract

A depression in antibody-mediated immunity (AMI) measured both in terms of circulating antibody and plaque-forming cells in the spleen was observed in CFW mice infected with M. lepraemurium when sheep red blood cells (SRBC) and human gammaglobulin (HGG) were used as antigens. The impairment in AMI was evident only after 75 days of infection thereafter the antibody response to SRBC antigen progressively decreased until the last day of experimentation (135 days). Within the first 60 days of infection no alteration in AMI was observed with the HGG antigen while the response to the SRBC antigen was significantly higher in the infected animals than in uninfected controls.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bonomo L., Dammacco F., Gillardi U. Hypergammaglobulinemia, secondary macroglobulinemia and paraproteinemia in leprosy. Int J Lepr Other Mycobact Dis. 1969 Jul-Sep;37(3):280–287. [PubMed] [Google Scholar]
  2. Bullock W. E., Jr, Fasal P. Studies of immune mechanisms in leprosy. 3. The role of cellular and humoral factors in impairment of the in vitro immune response. J Immunol. 1971 Apr;106(4):888–899. [PubMed] [Google Scholar]
  3. COCHRANE R. G. Notification of leprosy. Int J Lepr. 1953 Jul-Sep;21(3):347–362. [PubMed] [Google Scholar]
  4. Carteron B., Fauran P., Courmes E. Analyse immuno-Pelectrophorétique de sérums de lépreux de la Guadelope. Note préliminaire. Med Trop (Mars) 1970 May-Jun;30(3):347–352. [PubMed] [Google Scholar]
  5. Dwyer J. M., Bullock W. E., Fields J. P. Disturbance of the blood T:B lymphocyte ratio in lepromatous leprosy. Clinical and immunologic correlations. N Engl J Med. 1973 May 17;288(20):1036–1039. doi: 10.1056/NEJM197305172882002. [DOI] [PubMed] [Google Scholar]
  6. Godal T., Myklestad B., Samuel D. R., Myrvang B. Characterization of the cellular immune defect in lepromatous leprosy: a specific lack of circulating Mycobacterium leprae-reactive lymphocytes. Clin Exp Immunol. 1971 Dec;9(6):821–831. [PMC free article] [PubMed] [Google Scholar]
  7. HOXTER G., BATISTA L., VELLINI L. L. Estudos electroforéticos nas diversas formas clänicas da lepra. Rev Bras Leprol. 1951 Mar;19(1):27–40. [PubMed] [Google Scholar]
  8. Hart P. D., Rees R. J. Lepromin and Kveim antigen reactivity in man, and their relation to tuberculin reactivity. Br Med Bull. 1967 Jan;23(1):80–85. doi: 10.1093/oxfordjournals.bmb.a070522. [DOI] [PubMed] [Google Scholar]
  9. JERNE N. K., NORDIN A. A. Plaque formation in agar by single antibody-producing cells. Science. 1963 Apr 26;140(3565):405–405. [PubMed] [Google Scholar]
  10. Jha P., Balakrishnan K., Talwar G. P., Bhutani L. K. Status of humoral immune responses in leprosy. Int J Lepr Other Mycobact Dis. 1971 Jan-Mar;39(1):14–19. [PubMed] [Google Scholar]
  11. Kwapinski J. B., Kwapinski E. H. Immunological reactions of Mycobacterium leprae and Mycobacterium lepraemurium grown in cayman. Can J Microbiol. 1973 Jun;19(6):764–766. doi: 10.1139/m73-124. [DOI] [PubMed] [Google Scholar]
  12. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  13. Lim S. D., Kiszkiss D. F., Jacobson R. R., Choi Y. S., Good R. A. Thymus-dependent lymphocytes of peripheral blood in leprosy patients. Infect Immun. 1974 Feb;9(2):394–399. doi: 10.1128/iai.9.2.394-399.1974. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Malaviya A. N., Pasricha A., Pasricha J. S., Mehta J. S. Significance of serologic abnormalities in lepromatous leprosy. Int J Lepr Other Mycobact Dis. 1972 Oct-Dec;40(4):361–365. [PubMed] [Google Scholar]
  15. Ptak W., Gaugas J. M., Rees R. J., Allison A. C. Immune responses in mice with murine leprosy. Clin Exp Immunol. 1970 Jan;6(1):117–124. [PMC free article] [PubMed] [Google Scholar]
  16. Reyes-Gómez P., Estrada-Parra S., Rojas-Espinosa O. Isolation of polysaccharides from tissues infected with Mycobacterium lepraemurium. Int J Lepr Other Mycobact Dis. 1968 Jan-Mar;36(1):60–63. [PubMed] [Google Scholar]
  17. Rojas-Espinosa O., Mendez-Navarrete I., Estrada-Parra S. Presence of C1q-reactive immune complexes in patients with leprosy. Clin Exp Immunol. 1972 Oct;12(2):215–223. [PMC free article] [PubMed] [Google Scholar]
  18. Saha K., Mittal M. M., Ray S. N. Consequences of smallpox vaccination in leprosy patients. Infect Immun. 1973 Sep;8(3):301–308. doi: 10.1128/iai.8.3.301-308.1973. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Sato S., Imi M. The surface structure of M. leprae. Int J Lepr Other Mycobact Dis. 1968 Jul-Sep;36(3):303–308. [PubMed] [Google Scholar]
  20. Shwe T. Clinical significance of autoimmune antibodies in leprosy. Trans R Soc Trop Med Hyg. 1972;66(5):749–753. doi: 10.1016/0035-9203(72)90089-2. [DOI] [PubMed] [Google Scholar]
  21. Talwar G. P., Krishnan A. D., Mehra V. L., Blum E. A., Pearson J. M. Evaluation of cell mediated immune responses in untreated cases of leprosy. Clin Exp Immunol. 1972 Oct;12(2):195–203. [PMC free article] [PubMed] [Google Scholar]
  22. Turk J. L., Waters M. F. Cell-mediated immunity in patients with leprosy. Lancet. 1969 Aug 2;2(7614):243–246. doi: 10.1016/s0140-6736(69)90009-9. [DOI] [PubMed] [Google Scholar]
  23. Turk J. L., Waters M. F. Immunological significance of changes in lymph nodes across the leprosy spectrum. Clin Exp Immunol. 1971 Mar;8(3):363–376. [PMC free article] [PubMed] [Google Scholar]
  24. Ulrich M., Pinardi M. E., Convit J. A study of antibody response in leprosy. Int J Lepr Other Mycobact Dis. 1969 Jan-Mar;37(1):22–27. [PubMed] [Google Scholar]
  25. Waldorf D. S., Sheagren J. N., Trautman J. R., Block J. B. Impaired delayed hypersensitivity in patients with lepromatous leprosy. Lancet. 1966 Oct 8;2(7467):773–776. doi: 10.1016/s0140-6736(66)90366-7. [DOI] [PubMed] [Google Scholar]

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