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. 1988 May;72(2):274–279.

Lymphocyte phenotypes in the intestinal mucosa of sheep infected with Trichostrongylus colubriformis.

M D Gorrell 1, G Willis 1, M R Brandon 1, A K Lascelles 1
PMCID: PMC1541552  PMID: 3409545

Abstract

Monoclonal antibodies to ovine lymphocyte surface antigens were used in an immunohistochemical study of the intestine of sheep. In the epithelium CD8+ cells predominated whereas the majority of lamina propria T lymphocytes were CD4+. Infection of sheep with the parasitic nematode Trichostrongylus colubriformis including sufficiently large numbers of parasites to induce protective immunity did not alter the number of CD4+ or CD8+ lymphocytes in the intestinal mucosa. In contrast, exposure of naive sheep to a single large infection of T. colubriformis resulted in a substantial decrease in number of CD8+ cells and moderate decreases in number of CD4+ cells in the duodenal but not the jejunal mucosa. MHC class II antigens were not detected either in or on epithelial cells of the sheep small intestine.

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Selected References

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