Abstract
Soluble mediators from peripheral blood lymphocytes activated either by skin test antigens or by alloantigens restored the delayed type hypersensitivity (DTH) reaction in the majority of anergic surgical patients who are at increased risk for sepsis and mortality. Antigen had to be injected together with the mediators and the individual had to be reactive to the antigen for restoration. These results suggest that restoration of the DTH response depends on the ability of cytokines produced and acting in a non-specific manner to promote the response of the anergic patients' specific antigen-sensitive cells to antigen.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Christou N. V. Host-defence mechanisms in surgical patients: a correlative study of the delayed hypersensitivity skin-test response, granulocyte function and sepsis. Can J Surg. 1985 Jan;28(1):39-46, 49. [PubMed] [Google Scholar]
- Dwyer J. M., Kantor F. S. Regulation of delayed hypersensitivity. Failure to transfer delayed hypersensitivity to desensitized guinea pigs. J Exp Med. 1973 Jan 1;137(1):32–41. doi: 10.1084/jem.137.1.32. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Meakins J. L., Pietsch J. B., Bubenick O., Kelly R., Rode H., Gordon J., MacLean L. D. Delayed hypersensitivity: indicator of acquired failure of host defenses in sepsis and trauma. Ann Surg. 1977 Sep;186(3):241–250. doi: 10.1097/00000658-197709000-00002. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Palacios R. Mechanism of T cell activation: role and functional relationship of HLA-DR antigens and interleukins. Immunol Rev. 1982;63:73–110. doi: 10.1111/j.1600-065x.1982.tb00412.x. [DOI] [PubMed] [Google Scholar]
- Rode H. N., Christou N. V., Bubenik O., Superina R., Gordon J., Meakins J. L., MacLean L. D. Lymphocyte function in anergic patients. Clin Exp Immunol. 1982 Jan;47(1):155–161. [PMC free article] [PubMed] [Google Scholar]
- Waksman B. H. Cellular hypersensitivity and immunity: conceptual changes in last decade. Cell Immunol. 1979 Jan;42(1):155–169. doi: 10.1016/0008-8749(79)90229-6. [DOI] [PubMed] [Google Scholar]
- Warnke R., Levy R. Detection of T and B cell antigens hybridoma monoclonal antibodies: a biotin-avidin-horseradish peroxidase method. J Histochem Cytochem. 1980 Aug;28(8):771–776. doi: 10.1177/28.8.7003003. [DOI] [PubMed] [Google Scholar]