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. 1988 Jan;71(1):39–44.

Predominance of IgA deposits in glomeruli of Schistosoma mansoni infected mice.

A K el-Sherif 1, D Befus 1
PMCID: PMC1541649  PMID: 3127090

Abstract

We found that IgA is predominant among the immune deposits in the renal glomeruli of mice infected with Schistosoma mansoni, and thus conducted an analysis of the deposition of different immunoglobulin isotypes in the glomeruli throughout the course of infection in mice. Both immunofluorescent and immunoperoxidase methodologies were employed and compared. The abundance of S. mansoni antigens and the isotypes of antibodies to these antigens were examined in the sera and kidney eluates of mice during the course of infection and the results were related to the findings of immunohistopathology. Our observations suggest that at least some immune complexes form in situ in the glomeruli of infected mice and support a possible role of liver damage in the pathogenesis of renal disease in schistosomiasis. Intestinal mucosal immune responses to schistosome antigens may be important in the evolution of renal disease. In addition, the relevance of the murine model to human schistosomal nephropathy is questioned.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Andrade Z. A., Rocha H. Schistosomal glomerulopathy. Kidney Int. 1979 Jul;16(1):23–29. doi: 10.1038/ki.1979.99. [DOI] [PubMed] [Google Scholar]
  2. Batsford S. R., Takamiya H., Rohrbach R., Vogt A. Pathogenetic role of mesangial immune deposits. Proc Eur Dial Transplant Assoc. 1979;16:535–541. [PubMed] [Google Scholar]
  3. Berger J., Yaneva H., Nabarra B. Glomerular changes in patients with cirrhosis of the liver. Adv Nephrol Necker Hosp. 1977;7:3–14. [PubMed] [Google Scholar]
  4. Cavallo T., Galvanek E. G., Ward P. A., von Lichtenberg F. The nephropathy of experimental hepatosplenic schistosomiasis. Am J Pathol. 1974 Sep;76(3):433–450. [PMC free article] [PubMed] [Google Scholar]
  5. Digeon M., Droz D., Noel L. H., Riza J., Rieumailhol C., Bach J. F., Santoro F., Capron A. The role of circulating immune complexes in the glomerular disease of experimental hepatosplenic schistosomiasis. Clin Exp Immunol. 1979 Mar;35(3):329–337. [PMC free article] [PubMed] [Google Scholar]
  6. Emancipator S. N., Gallo G. R., Lamm M. E. Experimental IgA nephropathy induced by oral immunization. J Exp Med. 1983 Feb 1;157(2):572–582. doi: 10.1084/jem.157.2.572. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hoshino-Shimizu S., De Brito T., Kanamura H. Y., Canto A. L., Silva A. O., Campos A. R., Penna D. O., Da Silva L. C. Human schistosomiasis: Schistosoma mansoni antigen detection in renal glomeruli. Trans R Soc Trop Med Hyg. 1976;70(5-6):492–496. doi: 10.1016/0035-9203(76)90135-8. [DOI] [PubMed] [Google Scholar]
  8. Hoshino S., Camargo M. E., da Silva L. C. Standardization of a hemagglutination test for schistosomiasis with formalin-treated human erythrocytes. Am J Trop Med Hyg. 1970 May;19(3):463–470. doi: 10.4269/ajtmh.1970.19.463. [DOI] [PubMed] [Google Scholar]
  9. Houba V. Experimental renal disease due to schistosomiasis. Kidney Int. 1979 Jul;16(1):30–43. doi: 10.1038/ki.1979.100. [DOI] [PubMed] [Google Scholar]
  10. Houba V., Koech D. K., Sturrock R. F., Butterworth A. E., Kusel J. R., Mahmoud A. A. Soluble antigens and antibodies in sera from baboons infected with Schistosoma mansoni. J Immunol. 1976 Aug;117(2):705–707. [PubMed] [Google Scholar]
  11. Jeannet M., Lambert P. H. Immunological studies on eluates from human kidney grafts. Clin Immunol Immunopathol. 1975 Nov;4(4):478–488. doi: 10.1016/0090-1229(75)90089-6. [DOI] [PubMed] [Google Scholar]
  12. Levy M., Kleinknecht C. Membranous glomerulonephritis and hepatitis B virus infection. Nephron. 1980;26(6):259–265. doi: 10.1159/000181999. [DOI] [PubMed] [Google Scholar]
  13. Lomax-Smith J. D., Zabrowarny L. A., Howarth G. S., Seymour A. E., Woodroffe A. J. The immunochemical characterization of mesangial IgA deposits. Am J Pathol. 1983 Dec;113(3):359–364. [PMC free article] [PubMed] [Google Scholar]
  14. Nash T. E. Immune complex size determines the clearance rate of a circulating antigen in schistosome-infected mice. Am J Trop Med Hyg. 1984 Jul;33(4):621–626. doi: 10.4269/ajtmh.1984.33.621. [DOI] [PubMed] [Google Scholar]
  15. Nash T. Fate and mechanism of clearance of PSAP, a schistosome antigen, in schistosomiasis. J Immunol. 1983 Nov;131(5):2520–2523. [PubMed] [Google Scholar]
  16. Peppard J., Orlans E., Payne A. W., Andrew E. The elimination of circulating complexes containing polymeric IgA by excretion in the bile. Immunology. 1981 Jan;42(1):83–89. [PMC free article] [PubMed] [Google Scholar]
  17. Qian Z. L., Deelder A. M. Schistosoma japonicum: immunological response to circulating polysaccharide antigens in rabbits with a light infection. Exp Parasitol. 1983 Jun;55(3):394–403. doi: 10.1016/0014-4894(83)90037-1. [DOI] [PubMed] [Google Scholar]
  18. Rifai A., Mannik M. Clearance of circulating IgA immune complexes is mediated by a specific receptor on Kupffer cells in mice. J Exp Med. 1984 Jul 1;160(1):125–137. doi: 10.1084/jem.160.1.125. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Sancho J., Egido J., Rivera F., Hernando L. Immune complexes in IgA nephropathy: presence of antibodies against diet antigens and delayed clearance of specific polymeric IgA immune complexes. Clin Exp Immunol. 1983 Oct;54(1):194–202. [PMC free article] [PubMed] [Google Scholar]
  20. Santoro F., Bout D., Camus D., Dessaint J. P., Capron A. Immune complexes in schistosomiasis. V. Characterization and quantitation of the immunoglobulins present in IC. Rev Inst Med Trop Sao Paulo. 1977 May-Jun;19(3):156–160. [PubMed] [Google Scholar]
  21. Tada T., Kondo Y., Okumura K., Sano M., Yokogawa M. Schistosoma japonicum: immunopathology of nephritis in Macaca fascicularis. Exp Parasitol. 1975 Dec;38(3):291–302. doi: 10.1016/0014-4894(75)90114-9. [DOI] [PubMed] [Google Scholar]
  22. Von Lichtenberg F., Sadun E. H., Cheever A. W., Erickson D. G., Johnson A. J., Boyce H. W. Experimental infection with Schistosoma japonicum in chimpanzees. Am J Trop Med Hyg. 1971 Nov;20(6):850–893. doi: 10.4269/ajtmh.1971.20.850. [DOI] [PubMed] [Google Scholar]
  23. Zodda D. M., Abdel-Hafez S. K., Phillips S. M. Characterization of monoclonal antibodies against Schistosoma mansoni. Am J Trop Med Hyg. 1983 Jan;32(1):69–77. doi: 10.4269/ajtmh.1983.32.69. [DOI] [PubMed] [Google Scholar]
  24. van Marck E. A., Deelder A. M., Gigase P. L. Effect of partial portal vein ligation on immune glomerular deposits in Schistosoma mansoni-infected mice. Br J Exp Pathol. 1977 Aug;58(4):412–417. [PMC free article] [PubMed] [Google Scholar]

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