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. 1988 Sep;73(3):456–460.

Anticardiolipin antibodies in systemic sclerosis: immunological and clinical associations.

R G Malia 1, M Greaves 1, L M Rowlands 1, A C Lawrence 1, A Hume 1, N R Rowell 1, J Moult 1, C M Holt 1, N Lindsey 1, P Hughes 1
PMCID: PMC1541778  PMID: 2974767

Abstract

Anticardiolipin antibodies of IgG/IgM class were detected in seven of 28 patients with systemic sclerosis including five of 16 patients severely affected by extensive visceral disease. This severely affected sub-group also showed significant elevations of plasma levels of von Willebrand factor antigen in 10 cases and serum C1q binding activity in seven cases respectively. This triple association raises the possibility that multiple immunological mechanisms are involved in the pathogenesis of systemic sclerosis and its vascular lesions.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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