Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1989 Sep;77(3):314–318.

Relation between lymphocytotoxic antibodies, anti-DNA antibodies and a common anti-DNA antibody idiotype PR4 in patients with systemic lupus erythematosus, their relatives and spouses.

S H Le Page 1, W Williams 1, D Parkhouse 1, G Cambridge 1, L MacKenzie 1, P M Lydyard 1, D A Isenberg 1
PMCID: PMC1542061  PMID: 2805403

Abstract

Forty-two patients with systemic lupus erythematosus (SLE), 65 of their healthy relatives and 20 spouses were studied for the presence of lymphocytotoxic antibodies (LCA), anti-lymphocyte antibodies (ALA), antibodies to DNA and a common idiotype (Id) PR4. Seventy-one per cent of the patients had positive levels of LCA, and in 34% the PR4 Id was detected; normal levels were found in their families. Anti-PR4, an anti-Id, failed to block the lymphocytotoxic activity in those nine patients who both carried the Id and had LCA. This indicates that the Id was not present on LCA. There was no correlation between anti-DNA antibodies and LCA, suggesting that different mechanisms are involved in their expression.

Full text

PDF
318

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bluestein H. G., Zvaifler N. J., Weisman M. H., Shapiro R. F. Lymphocyte alteration by procainamide: relation to drug-induced lupus erythematosus syndrome. Lancet. 1979 Oct 20;2(8147):816–819. doi: 10.1016/s0140-6736(79)92174-3. [DOI] [PubMed] [Google Scholar]
  2. Bresnihan B., Grigor R. R., Hughes G. R. Lymphocytotoxic antibodies in systemic lupus erythematosus: their clinical significance. J Clin Pathol Suppl (R Coll Pathol) 1979;13:112–115. doi: 10.1136/jcp.s3-13.1.112. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. DeHoratius R. J., Messner R. P. Lymphocytotoxic antibodies in family members of patients with systemic lupus erythematosus. J Clin Invest. 1975 Jun;55(6):1254–1258. doi: 10.1172/JCI108044. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Diamond B., Scharff M. D. Somatic mutation of the T15 heavy chain gives rise to an antibody with autoantibody specificity. Proc Natl Acad Sci U S A. 1984 Sep;81(18):5841–5844. doi: 10.1073/pnas.81.18.5841. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Folomeeva O., Nassonova V. A., Alekberova A. S., Talal N., Williams R. C., Jr Comparative studies of antilymphocyte, antipolynucleotide, and antiviral antibodies among families of patients with systemic lupus erythematosus. Arthritis Rheum. 1978 Jan-Feb;21(1):23–27. doi: 10.1002/art.1780210105. [DOI] [PubMed] [Google Scholar]
  6. Hazelton R. A. A study of lymphocytotoxins in families of patients with systemic lupus erythematosus. Ann Rheum Dis. 1984 Apr;43(2):136–139. doi: 10.1136/ard.43.2.136. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Isenberg D. A., Shoenfeld Y., Walport M., Mackworth-Young C., Dudeney C., Todd-Pokropek A., Brill S., Weinberger A., Pinkas J. Detection of cross-reactive anti-DNA antibody idiotypes in the serum of systemic lupus erythematosus patients and of their relatives. Arthritis Rheum. 1985 Sep;28(9):999–1007. doi: 10.1002/art.1780280907. [DOI] [PubMed] [Google Scholar]
  8. Kaburaki J., Stollar B. D. Identification of human anti-DNA, anti-RNP, anti-SM, and anti-SS-A serum antibodies bearing the cross-reactive 16/6 idiotype. J Immunol. 1987 Jul 15;139(2):385–392. [PubMed] [Google Scholar]
  9. Lee S. K., Singh J., Taylor R. B. Subclasses of T cells with different sensitivities to cytotoxic antibody in the presence of anesthetics. Eur J Immunol. 1975 Apr;5(4):259–262. doi: 10.1002/eji.1830050408. [DOI] [PubMed] [Google Scholar]
  10. Lehman T. J., Curd J. G., Zvaifler N. J., Hanson V. The association of antinuclear antibodies, antilymphocyte antibodies, and C4 activation among the relatives of children with systemic lupus erythematosus. Arthritis Rheum. 1982 May;25(5):556–561. doi: 10.1002/art.1780250510. [DOI] [PubMed] [Google Scholar]
  11. Locniskar M., Zumla A., Mudd D. W., Isenberg D. A., Williams W., McAdam K. P. Human monoclonal antibodies to phenolic glycolipid-I derived from patients with leprosy, and production of specific anti-idiotypes. Immunology. 1988 Jun;64(2):245–251. [PMC free article] [PubMed] [Google Scholar]
  12. Lydyard P. M., Isenberg D., de Sousa B., Mackenzie L., Cooke A. A cross-reactive idiotype on anti-DNA and lymphocytotoxic antibodies. Clin Exp Immunol. 1987 Mar;67(3):500–506. [PMC free article] [PubMed] [Google Scholar]
  13. Malavé I., Papa R., Layrisse Z. Lymphocytotoxic antibodies in SLE patients and their relatives. Arthritis Rheum. 1976 Jul-Aug;19(4):700–704. doi: 10.1002/1529-0131(197607/08)19:4<700::aid-art1780190407>3.0.co;2-s. [DOI] [PubMed] [Google Scholar]
  14. Peake P. W., Greenstein J. D., Timmermans V., Gavrilovic L., Charlesworth J. A. Lymphocytotoxic antibodies in systemic lupus erythematosus: studies of their temperature dependence, binding characteristics, and specificity in vitro. Ann Rheum Dis. 1988 Sep;47(9):725–732. doi: 10.1136/ard.47.9.725. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Shoenfeld Y., Zamir R., Joshua H., Lavie G., Pinkhas J. Human monoclonal anti-DNA antibodies react as lymphocytotoxic antibodies. Eur J Immunol. 1985 Oct;15(10):1024–1028. doi: 10.1002/eji.1830151012. [DOI] [PubMed] [Google Scholar]
  16. Symmons D. P., Coppock J. S., Bacon P. A., Bresnihan B., Isenberg D. A., Maddison P., McHugh N., Snaith M. L., Zoma A. S. Development and assessment of a computerized index of clinical disease activity in systemic lupus erythematosus. Members of the British Isles Lupus Assessment Group (BILAG). Q J Med. 1988 Nov;69(259):927–937. [PubMed] [Google Scholar]
  17. TERASAKI P. I., MCCLELLAND J. D. MICRODROPLET ASSAY OF HUMAN SERUM CYTOTOXINS. Nature. 1964 Dec 5;204:998–1000. doi: 10.1038/204998b0. [DOI] [PubMed] [Google Scholar]
  18. Tan E. M., Cohen A. S., Fries J. F., Masi A. T., McShane D. J., Rothfield N. F., Schaller J. G., Talal N., Winchester R. J. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum. 1982 Nov;25(11):1271–1277. doi: 10.1002/art.1780251101. [DOI] [PubMed] [Google Scholar]
  19. Temesvari P., Denburg J., Denburg S., Carbotte R., Bensen W., Singal D. Serum lymphocytotoxic antibodies in neuropsychiatric lupus: a serial study. Clin Immunol Immunopathol. 1983 Aug;28(2):243–251. doi: 10.1016/0090-1229(83)90158-7. [DOI] [PubMed] [Google Scholar]
  20. Williams W., Zumla A., Behrens R., Locniskar M., Voller A., McAdam K. P., Isenberg D. A. Studies of a common idiotype PR4 in autoimmune rheumatic disease. Arthritis Rheum. 1988 Sep;31(9):1097–1104. doi: 10.1002/art.1780310903. [DOI] [PubMed] [Google Scholar]
  21. Zumla A., Williams W., Shall S., Locniskar M., Leigh I., McAdam K. P., Isenberg D. Human monoclonal antibodies to phenolic glycolipid-1 from leprosy patients cross react with poly(ADP-ribose), polynucleotides and tissue bound antigens. Autoimmunity. 1988;1(3):183–195. doi: 10.3109/08916938808997163. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES