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. 1987 Dec;70(3):508–514.

Activation of liver macrophages in murine malaria is enhanced by vaccination.

J Taverne 1, D Rahman 1, H M Dockrell 1, A Alavi 1, C Leveton 1, J H Playfair 1
PMCID: PMC1542187  PMID: 2830070

Abstract

During blood-stage infection of mice with a lethal variant of Plasmodium yoelii, cells in both spleen and liver became activated to reach a peak at day 5. In mice protected by vaccination, activation was accelerated after infection. The most striking difference observed was in the 10-fold greater yield of infiltrating cells, including macrophages, obtained from the liver just before the mice recovered. Their capacity to give an oxidative burst and their cytotoxic activity against tumour cells was also more than 10 times normal. This suggests that the recruitment of inflammatory cells to the liver plays an important role in the protection of vaccinated mice against malaria.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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