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. 1987 Oct;70(1):209–216.

Depressed natural killer cell activity in acute myocardial infarction.

K Klarlund 1, B K Pedersen 1, T G Theander 1, V Andersen 1
PMCID: PMC1542217  PMID: 3500813

Abstract

Natural killer (NK) cell activity against K562 target cells was measured in patients within 24 h of acute myocardial infarction (AMI) and regularly thereafter for 6 weeks. NK cell activity was suppressed on days 1, 3, and 7 (P less than 0.01), day 14 (P less than 0.05) and at 6 weeks (P = 0.05) when compared to controls. Interferon, interleukin 2 and indomethacin enhanced NK cell activity on all days measured, but did not completely restore the defective NK cell activity. Serum from the patients did not suppress the NK cell activity of healthy mononuclear cells. The number of NK cells, identified as large granular lymphocytes (LGL), measured on days 1, 3, and 14 and at 6 weeks was not reduced in comparison to that of controls. Thus, the defective NK cell activity can be characterized as functional.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aarstad H. J., Gaudernack G., Seljelid R. Stress causes reduced natural killer activity in mice. Scand J Immunol. 1983 Nov;18(5):461–464. doi: 10.1111/j.1365-3083.1983.tb00878.x. [DOI] [PubMed] [Google Scholar]
  2. Brahmi Z., Thomas J. E., Park M., Park M., Dowdeswell I. R. The effect of acute exercise on natural killer-cell activity of trained and sedentary human subjects. J Clin Immunol. 1985 Sep;5(5):321–328. doi: 10.1007/BF00918251. [DOI] [PubMed] [Google Scholar]
  3. Ceremuzyński L. Hormonal and metabolic reactions evoked by acute myocardial infarction. Circ Res. 1981 Jun;48(6 Pt 1):767–776. doi: 10.1161/01.res.48.6.767. [DOI] [PubMed] [Google Scholar]
  4. El-Hag A., Clark R. A. Down-regulation of human natural killer activity against tumors by the neutrophil myeloperoxidase system and hydrogen peroxide. J Immunol. 1984 Dec;133(6):3291–3297. [PubMed] [Google Scholar]
  5. Hellstrand K., Hermodsson S., Strannegård O. Evidence for a beta-adrenoceptor-mediated regulation of human natural killer cells. J Immunol. 1985 Jun;134(6):4095–4099. [PubMed] [Google Scholar]
  6. Hoffman T., Hirata F., Bougnoux P., Fraser B. A., Goldfarb R. H., Herberman R. B., Axelrod J. Phospholipid methylation and phospholipase A2 activation in cytotoxicity by human natural killer cells. Proc Natl Acad Sci U S A. 1981 Jun;78(6):3839–3843. doi: 10.1073/pnas.78.6.3839. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hoffman T. Natural killer funciton in systemic lupus erythematosus. Arthritis Rheum. 1980 Jan;23(1):30–35. doi: 10.1002/art.1780230106. [DOI] [PubMed] [Google Scholar]
  8. Horváth M., Jovanovich N., Kádár K., Györffy G. Distribution of T-lymphocyte subsets in patients with vascular diseases. Cor Vasa. 1984;26(6):429–437. [PubMed] [Google Scholar]
  9. Humphres R. C., Gelber R. H., Krahenbuhl J. L. Suppressed natural killer cell activity during episodes of erythema nodosum leprosum in lepromatous leprosy. Clin Exp Immunol. 1982 Sep;49(3):500–508. [PMC free article] [PubMed] [Google Scholar]
  10. Jensen J. R., Thestrup-Pedersen K., From E. Fluctuations in natural killer cell activity in early syphilis. Br J Vener Dis. 1983 Feb;59(1):30–32. doi: 10.1136/sti.59.1.30. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Keller S. E., Weiss J. M., Schleifer S. J., Miller N. E., Stein M. Stress-induced suppression of immunity in adrenalectomized rats. Science. 1983 Sep 23;221(4617):1301–1304. doi: 10.1126/science.6612346. [DOI] [PubMed] [Google Scholar]
  12. Mathews J. D., Whittingham S., Mackay I. R. Autoimmune mechanisms in human vascular disease. Lancet. 1974 Dec 14;2(7894):1423–1427. doi: 10.1016/s0140-6736(74)90077-4. [DOI] [PubMed] [Google Scholar]
  13. Onsrud M., Thorsby E. Influence of in vivo hydrocortisone on some human blood lymphocyte subpopulations. I. Effect on natural killer cell activity. Scand J Immunol. 1981;13(6):573–579. doi: 10.1111/j.1365-3083.1981.tb00171.x. [DOI] [PubMed] [Google Scholar]
  14. Parrillo J. E., Fauci A. S. Comparison of the effector cells in human spontaneous cellular cytotoxicity and antibody-dependent cellular cytotoxicity: differential sensitivity of effector cells to in vivo and in vitro corticosteroids. Scand J Immunol. 1978;8(2):99–107. doi: 10.1111/j.1365-3083.1978.tb00501.x. [DOI] [PubMed] [Google Scholar]
  15. Pedersen B. K., Beyer J. M. Characterization of the in vitro effects of glucocorticosteroids on NK cell activity. Allergy. 1986 Apr;41(3):220–224. doi: 10.1111/j.1398-9995.1986.tb00303.x. [DOI] [PubMed] [Google Scholar]
  16. Pedersen B. K. Natural killer cells in relation to disease and treatment. Allergy. 1985 Nov;40(8):547–557. doi: 10.1111/j.1398-9995.1985.tb00881.x. [DOI] [PubMed] [Google Scholar]
  17. Pedersen B. K., Oxholm P., Manthorpe R., Andersen V. Interleukin 2 augmentation of the defective natural killer cell activity in patients with primary Sjögren's syndrome. Clin Exp Immunol. 1986 Jan;63(1):1–7. [PMC free article] [PubMed] [Google Scholar]
  18. Poston R. N., Davies D. F. Immunity and inflammation in the pathogenesis of atherosclerosis. A review. Atherosclerosis. 1974 May-Jun;19(3):353–367. doi: 10.1016/s0021-9150(74)80001-8. [DOI] [PubMed] [Google Scholar]
  19. Timonen T., Saksela E. Isolation of human NK cells by density gradient centrifugation. J Immunol Methods. 1980;36(3-4):285–291. doi: 10.1016/0022-1759(80)90133-7. [DOI] [PubMed] [Google Scholar]
  20. Uchida A., Colot M., Micksche M. Suppression of natural killer cell activity by adherent effusion cells of cancer patients. Suppression of motility, binding capacity and lethal hit of NK cells. Br J Cancer. 1984 Jan;49(1):17–23. doi: 10.1038/bjc.1984.4. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Yam L. T., Li C. Y., Crosby W. H. Cytochemical identification of monocytes and granulocytes. Am J Clin Pathol. 1971 Mar;55(3):283–290. doi: 10.1093/ajcp/55.3.283. [DOI] [PubMed] [Google Scholar]

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