Skip to main content
PMC home page
Clinical and Experimental Immunology logoLink to Clinical and Experimental Immunology
. 1986 Aug;65(2):381–386.

Modulation of cellular immunity in malnutrition: effect of interleukin 1 on suppressor T cell activity.

L Hoffman-Goetz, R Keir, C Young
PMCID: PMC1542311  PMID: 2947763

Abstract

T-lymphocyte mitogenesis is impaired in protein-energy malnutrition. The effect of interleukin 1 (IL-1) on the augmentation of suppressor cell activity during concanavalin A-induced lymphocyte proliferation was measured using IL-1 and lymphocytes from protein malnourished and control rabbits. Addition of IL-1 to lymphocyte cultures from control donors enhanced the suppression of fresh lymphocytes to phytohaemagglutinin (PHA). Addition of IL-1 to lymphocyte cultures from malnourished donors abrograted the suppressor cell activity. Isoelectric focusing showed the presence of a protein band with a pI of about 7.0 in the IL-1 supernatants from protein malnourished and control donors. The results suggest that severe protein malnutrition alters the ability of T-lymphocytes to respond appropriately to IL-1 rather than simply affecting synthesis of this monokine.

Full text

PDF
383

Images in this article

383Fig. 1
on p.383

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Beatty D. W., Dowdle E. B. Deficiency in kwashiorkor serum of factors required for optimal lymphocyte transformation in vitro. Clin Exp Immunol. 1979 Mar;35(3):433–442. [PMC free article] [PubMed] [Google Scholar]
  2. Beer D. J., Dinarello C. A., Rosenwasser L. J., Rocklin R. E. Human monocyte-derived soluble product(s) has an accessory function in the generation of histamine- and concanavalin A-induced suppressor T cells. J Clin Invest. 1982 Aug;70(2):393–400. doi: 10.1172/JCI110629. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Beer D. J., Rosenwasser L. J., Dinarello C. A., Rocklin R. E. Cellular interactions in the generation and expression of histamine-induced suppressor activity. Cell Immunol. 1982 May 1;69(1):101–112. doi: 10.1016/0008-8749(82)90054-5. [DOI] [PubMed] [Google Scholar]
  4. Bell R. C., Hoffman-Goetz L., Keir R. Monocyte factors modulate in vitro T-lymphocyte mitogenesis in protein malnutrition. Clin Exp Immunol. 1986 Jan;63(1):194–202. [PMC free article] [PubMed] [Google Scholar]
  5. Chandra R. K. Numerical and functional deficiency in T helper cells in protein energy malnutrition. Clin Exp Immunol. 1983 Jan;51(1):126–132. [PMC free article] [PubMed] [Google Scholar]
  6. Dinarello C. A. Interleukin-1. Rev Infect Dis. 1984 Jan-Feb;6(1):51–95. doi: 10.1093/clinids/6.1.51. [DOI] [PubMed] [Google Scholar]
  7. Joffe M. I., Kew M., Rabson A. R. Lymphocyte subtypes in patients with atopic eczema, protein calorie malnutrition, SLE and liver disease. J Clin Lab Immunol. 1983 Feb;10(2):97–101. [PubMed] [Google Scholar]
  8. Kunkel S. L., Chensue S. W. Arachidonic acid metabolites regulate interleukin-1 production. Biochem Biophys Res Commun. 1985 Apr 30;128(2):892–897. doi: 10.1016/0006-291x(85)90130-5. [DOI] [PubMed] [Google Scholar]
  9. McMurray D. N. Cell-mediated immunity in nutritional deficiency. Prog Food Nutr Sci. 1984;8(3-4):193–228. [PubMed] [Google Scholar]
  10. Murphy P. A., Cebula T. A., Levin J., Windle B. E. Rabbit macrophages secrete two biochemically and immunologically distinct endogenous pyrogens. Infect Immun. 1981 Oct;34(1):177–183. doi: 10.1128/iai.34.1.177-183.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Murphy P. A., Hanson D. F., Guo Y. N., Angster D. E. The effects of variations in pH and temperature on the activation of mouse thymocytes by both forms of rabbit interleukin-1. Yale J Biol Med. 1985 Mar-Apr;58(2):115–123. [PMC free article] [PubMed] [Google Scholar]
  12. Murphy P. A., Simon P. L., Willoughby W. F. Endogenous pyrogens made by rabbit peritoneal exudate cells are identical with lymphocyte-activating factors made by rabbit alveolar macrophages. J Immunol. 1980 May;124(5):2498–2501. [PubMed] [Google Scholar]
  13. Ozato K., Ebert J. D. Concanavalin A potentiates syngeneic response in murine lymphocytes. J Exp Med. 1976 Jan 1;143(1):1–14. doi: 10.1084/jem.143.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Salimonu L. S., Johnson A. O., Williams A. I., Adeleye G. I., Osunkoya B. O. The occurrence and properties of E rosette inhibitory substance in the sera of malnourished children. Clin Exp Immunol. 1982 Mar;47(3):626–634. [PMC free article] [PubMed] [Google Scholar]
  15. Stobo J. D. Immunosuppression in man: suppression by macrophages can be mediated by interactions with regulatory T cells. J Immunol. 1977 Sep;119(3):918–924. [PubMed] [Google Scholar]
  16. Watson R. R., Chien G., Chung C. Thymosin treatment: serum corticosterone and lymphocyte mitogenesis in moderately and severely protein-malnourished mice. J Nutr. 1983 Mar;113(3):483–493. doi: 10.1093/jn/113.3.483. [DOI] [PubMed] [Google Scholar]

Articles from Clinical and Experimental Immunology are provided here courtesy of British Society for Immunology

RESOURCES