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. 1986 May;64(2):269–276.

Human american cutaneous leishmaniasis (Leishmania b. braziliensis) in Brazil: lymphoproliferative responses and influence of therapy.

S C Mendonça, S G Coutinho, R R Amendoeira, M C Marzochi, C Pirmez
PMCID: PMC1542340  PMID: 3742876

Abstract

The host defence to Leishmania parasites is believed to depend on cell-mediated immune responses. Three groups of inhabitants from an endemic area in Rio de Janeiro were studied: Group I consisted of 28 patients with cutaneous lesions, Group II of 28 healthy persons (without ulcers) but with positive Montenegro skin tests (MST) and Group III of 29 healthy persons with negative MST. The peripheral blood lymphocyte proliferative responses induced by leishmanial-antigens (Leishmania b. braziliensis lymphoproliferative response) as well as by Concanavalin A (Con A-lymphoproliferative response), both measured by 3H-thymidine incorporation were tested in each group. The results showed that: The Leishmania b. braziliensis lymphoproliferative response (L.b.b.-LPR) in healthy persons with positive MST (Group II) was higher than in patients prior to therapy (Group I); A significantly higher L.b.b.-LPR was found in patients and healthy persons with positive MST as compared to Group III (negative MST); The L.b.b.-LPR of Group I (patients) increased during antimonial therapy--this might possibly be related to the destruction of parasites; The levels of L.b.b.-LPR after therapy became similar to the ones before therapy; All individuals from the three groups had a positive Con A-lymphoproliferative response (Con A-LPR); All patients who had a histopathological picture of granulomatous reaction also had a positive L.b.b.-LPR; A poor response to antimonial therapy observed in six patients was associated with a low L.b.b.-LPR.

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Selected References

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  1. Bittencourt A. L., Andrade Z. A. Aspectos imunopatológicos na leishmaniose cutâneo-mucosa. Hospital (Rio J) 1967 Apr;71(4):975–984. [PubMed] [Google Scholar]
  2. Bryceson A. D., Bray R. S., Wolstencroft R. A., Dumonde D. C. Immunity in cutaneous leishmaniasis of the guinea-pig. Clin Exp Immunol. 1970 Sep;7(3):301–341. [PMC free article] [PubMed] [Google Scholar]
  3. Castes M., Agnelli A., Verde O., Rondón A. J. Characterization of the cellular immune response in American cutaneous leishmaniasis. Clin Immunol Immunopathol. 1983 May;27(2):176–186. doi: 10.1016/0090-1229(83)90068-5. [DOI] [PubMed] [Google Scholar]
  4. Castés M., Agnelli A., Rondón A. J. Mechanisms associated with immunoregulation in human American cutaneous leishmaniasis. Clin Exp Immunol. 1984 Aug;57(2):279–286. [PMC free article] [PubMed] [Google Scholar]
  5. Coutinho S. G., Louis J. A., Mauel J., Engers H. D. Induction by specific T lymphocytes of intracellular destruction of Leishmania major in infected murine macrophages. Parasite Immunol. 1984 Mar;6(2):157–169. doi: 10.1111/j.1365-3024.1984.tb00789.x. [DOI] [PubMed] [Google Scholar]
  6. Howard J. G., Hale C., Liew F. Y. Immunological regulation of experimental cutaneous leishmaniasis. III. Nature and significance of specific suppression of cell-mediated immunity in mice highly susceptible to Leishmania tropica. J Exp Med. 1980 Sep 1;152(3):594–607. doi: 10.1084/jem.152.3.594. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Lainson R. The American leishmaniases: some observations on their ecology and epidemiology. Trans R Soc Trop Med Hyg. 1983;77(5):569–596. doi: 10.1016/0035-9203(83)90185-2. [DOI] [PubMed] [Google Scholar]
  8. Lefford M. J. Lepromin as an indicator and inducer of protective immunity. Lepr Rev. 1981 Dec;52 (Suppl 1):221–229. doi: 10.5935/0305-7518.19810072. [DOI] [PubMed] [Google Scholar]
  9. Lopes U. G., Momen H., Grimaldi G., Jr, Marzochi M. C., Pacheco R. S., Morel C. M. Schizodeme and zymodeme characterization of Leishmania in the investigation of foci of visceral and cutaneous leishmaniasis. J Parasitol. 1984 Feb;70(1):89–98. [PubMed] [Google Scholar]
  10. Louis J. A., Zubler R. H., Coutinho S. G., Lima G., Behin R., Mauel J., Engers H. D. The in vitro generation and functional analysis of murine T cell populations and clones specific for a protozoan parasite, Leishmania tropica. Immunol Rev. 1982;61:215–243. doi: 10.1111/j.1600-065x.1982.tb00378.x. [DOI] [PubMed] [Google Scholar]
  11. Marzochi M. C., Coutinho S. G., Sabroza P. C., de Souza W. J. Reaço de imunofluorescência indireta e intradermorreaço para leishmaniose tegumentar americana em moradores na área de Jacarepaguá (Rio de Janeiro). Estudo comparativo dos resultados observados em 1974 e 1978. Rev Inst Med Trop Sao Paulo. 1980 May-Jun;22(3):149–155. [PubMed] [Google Scholar]
  12. Mauel J., Buchmüller Y., Behin R. Studies on the mechanisms of macrophage activation. I. Destruction of intracellular Leishmania enriettii in macrophages activated by cocultivation with stimulated lymphocytes. J Exp Med. 1978 Aug 1;148(2):393–407. doi: 10.1084/jem.148.2.393. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Petersen E. A., Neva F. A., Oster C. N., Bogaert Diaz H. Specific inhibition of lymphocyte-proliferation responses by adherent suppressor cells in diffuse cutaneous leishmaniasis. N Engl J Med. 1982 Feb 18;306(7):387–392. doi: 10.1056/NEJM198202183060702. [DOI] [PubMed] [Google Scholar]
  14. Titus R. G., Lima G. C., Engers H. D., Louis J. A. Exacerbation of murine cutaneous leishmaniasis by adoptive transfer of parasite-specific helper T cell populations capable of mediating Leishmania major-specific delayed-type hypersensitivity. J Immunol. 1984 Sep;133(3):1594–1600. [PubMed] [Google Scholar]
  15. Turk J. L., Bryceson A. D. Immunological phenomena in leprosy and related diseases. Adv Immunol. 1971;13:209–266. doi: 10.1016/s0065-2776(08)60185-6. [DOI] [PubMed] [Google Scholar]
  16. Witztum E., Spira D. T., Zuckerman A. Blast transformation in different stages of cutaneous leishmaniasis. Isr J Med Sci. 1978 Feb;14(2):244–247. [PubMed] [Google Scholar]
  17. de Souza W. J., Coutinho S. G., Marzochi M. C., de Toledo L. M., Gottlieb M. V. Utilizaço da reaço de imunofluorescéncia indireta no acompanhamento da terapêutica da leishmaniose tegumentar americana. Mem Inst Oswaldo Cruz. 1982 Jul-Sep;77(3):247–253. doi: 10.1590/s0074-02761982000300003. [DOI] [PubMed] [Google Scholar]

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