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. 1986 Dec;66(3):648–653.

Studies on rheumatoid factor: I. The effect of rheumatoid factor on the clearance of preformed immune complexes in mice.

D N Hogben, M E Devey
PMCID: PMC1542468  PMID: 3568452

Abstract

The blood clearance of passively transferred immune complexes (IC), preformed at different antigen-antibody ratios, was measured in mice with LPS-induced rheumatoid factor (RF) and in normal controls. RF had a differential effect on IC clearance, significantly enhancing clearance of complexes formed in antibody excess and slight antigen excess but inhibiting the clearance of complexes formed in moderate (x10) antigen excess. The results are discussed with regard to the mechanisms of IC clearance and suggest that RF may play an important role in governing the behaviour of immune complexes in vivo.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bockow B., Mannik M. Clearance and tissue uptake of immune complexes in complement-depleted and control mice. Immunology. 1981 Apr;42(4):497–504. [PMC free article] [PubMed] [Google Scholar]
  2. Coulie P. G., Van Snick J. Rheumatoid factor (RF) production during anamnestic immune responses in the mouse. III. Activation of RF precursor cells is induced by their interaction with immune complexes and carrier-specific helper T cells. J Exp Med. 1985 Jan 1;161(1):88–97. doi: 10.1084/jem.161.1.88. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Coulie P., Van Snick J. Rheumatoid factors and secondary immune responses in the mouse. II. Incidence, kinetics and induction mechanisms. Eur J Immunol. 1983 Nov;13(11):895–899. doi: 10.1002/eji.1830131107. [DOI] [PubMed] [Google Scholar]
  4. Coutelier J. P., Van Snick J. Binding of in vivo formed immune complexes by monoclonal mouse rheumatoid factors. Immunology. 1985 Feb;54(2):401–403. [PMC free article] [PubMed] [Google Scholar]
  5. Devey M. E., Bleasdale K., Stanley C., Steward M. W. Failure of affinity maturation leads to increased susceptibility to immune complex glomerulonephritis. Immunology. 1984 Jun;52(2):377–383. [PMC free article] [PubMed] [Google Scholar]
  6. Devey M. E., Steward M. W. The induction of chronic antigen-antibody complex disease in selectively bred mice producing either high or low affinity antibody to protein antigens. Immunology. 1980 Oct;41(2):303–311. [PMC free article] [PubMed] [Google Scholar]
  7. Doekes G., Schouten J., Cats A., Daha M. R. Reduction of the complement activation capacity of soluble IgG aggregates and immune complexes by IgM-rheumatoid factor. Immunology. 1985 Jul;55(3):555–564. [PMC free article] [PubMed] [Google Scholar]
  8. Dresser D. W., Popham A. M. Induction of an IgM anti-(bovine)-IgG response in mice by bacterial lipopolysaccharide. Nature. 1976 Dec 9;264(5586):552–554. doi: 10.1038/264552a0. [DOI] [PubMed] [Google Scholar]
  9. Frank M. M., Hamburger M. I., Lawley T. J., Kimberly R. P., Plotz P. H. Defective reticuloendothelial system Fc-receptor function in systemic lupus erythematosus. N Engl J Med. 1979 Mar 8;300(10):518–523. doi: 10.1056/NEJM197903083001002. [DOI] [PubMed] [Google Scholar]
  10. Haakenstad A. O., Mannik M. Saturation of the reticuloendothelial system with soluble immune complexes. J Immunol. 1974 May;112(5):1939–1948. [PubMed] [Google Scholar]
  11. Haakenstad A. O., Striker G. E., Mannik M. The disappearance kinetics and glomerular deposition of small-latticed soluble immune complexes. Immunology. 1982 Nov;47(3):407–414. [PMC free article] [PubMed] [Google Scholar]
  12. Lachmann P. J., Hughes-Jones N. C. Initiation of complement activation. Springer Semin Immunopathol. 1984;7(2-3):143–162. doi: 10.1007/BF01893018. [DOI] [PubMed] [Google Scholar]
  13. Lemm G., Hohendahl J., Warnatz H. Ein Festphasen-ELISA mit Spezifität für Rheumafaktoren der Klassen IgA, IgG und IgM. Immun Infekt. 1984 Oct;12(5):239–244. [PubMed] [Google Scholar]
  14. Malasit P., Bartolotti S. R., Humphrey J. H. Molecular composition of complement-solubilized complexes and their fate in vivo. Immunology. 1983 Apr;48(4):779–789. [PMC free article] [PubMed] [Google Scholar]
  15. Mannik M., Arend M. P., Hall A. P., Gilliland B. C. Studies on antigen-antibody complexes. I. Elimination of soluble complexes from rabbit circulation. J Exp Med. 1971 Apr 1;133(4):713–739. doi: 10.1084/jem.133.4.713. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Mannik M. Physicochemical and functional relationships of immune complexes. J Invest Dermatol. 1980 May;74(5):333–338. doi: 10.1111/1523-1747.ep12543582. [DOI] [PubMed] [Google Scholar]
  17. McGhee J. R., Farrar J. J., Michalek S. M., Mergenhagen S. E., Rosenstreich D. L. Cellular requirements for lipopolysaccharide adjuvanticity. A role for both T lymphocytes and macrophages for in vitro responses to particulate antigens. J Exp Med. 1979 Apr 1;149(4):793–807. doi: 10.1084/jem.149.4.793. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Nemazee D. A., Sato V. L. Induction of rheumatoid antibodies in the mouse. Regulated production of autoantibody in the secondary humoral response. J Exp Med. 1983 Aug 1;158(2):529–545. doi: 10.1084/jem.158.2.529. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Skogh T., Stendahl O. Complement-mediated delay in immune complex clearance from the blood owing to reduced deposition outside the reticuloendothelial system. Immunology. 1983 May;49(1):53–59. [PMC free article] [PubMed] [Google Scholar]
  20. Steward M. W., Turner M. W., Natvig J. B., Gaarder P. I. The binding affinities of rheumatoid factors interacting with the C gamma 3 homology region of human IgG. Clin Exp Immunol. 1973 Oct;15(2):145–152. [PMC free article] [PubMed] [Google Scholar]
  21. Van Snick J. L., Van Roost E., Markowetz B., Cambiaso C. L., Masson P. L. Enhancement by IgM rheumatoid factor of in vitro ingestion by macrophages and in vivo clearance of aggregated IgG or antigen-antibody complexes. Eur J Immunol. 1978 Apr;8(4):279–285. doi: 10.1002/eji.1830080412. [DOI] [PubMed] [Google Scholar]
  22. WEIGLE W. O. Elimination of antigen-antibody complexes from sera of rabbits. J Immunol. 1958 Sep;81(3):204–213. [PubMed] [Google Scholar]
  23. Ward P. A., Zvaifler N. J. Quantitative phagocytosis by neutrophils. II. Release of the C5-cleaving enzyme and inhibition of phagocytosis by rheumatoid factor. J Immunol. 1973 Dec;111(6):1777–1782. [PubMed] [Google Scholar]
  24. van Snick J. L., Masson P. L. Incidence and specificities of IgA and IgM anti-AgG autoantibodies in various mouse strains and colonies. J Exp Med. 1980 Jan 1;151(1):45–55. doi: 10.1084/jem.151.1.45. [DOI] [PMC free article] [PubMed] [Google Scholar]

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