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. 1987 Mar;67(3):500–506.

A cross-reactive idiotype on anti-DNA and lymphocytotoxic antibodies.

P M Lydyard, D Isenberg, B de Sousa, L Mackenzie, A Cooke
PMCID: PMC1542638  PMID: 2440630

Abstract

The possibility that shared idiotypes may be present on antibodies of different specificities was explored using sera from 13 patients with systemic lupus erythematosus. Eleven sera had anti-DNA and seven carried the 16/6 idiotype (ID). Two of the sera with 16/6 ID also had lymphocytotoxic antibodies, the activity of which was blocked by antibody to the 16/6 ID. Our studies reveal that 16/6 ID is present on two antibodies with different binding specificities.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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